PathWhiz

PathWhiz ID	Pathway	Meta Data
PW002402 View Pathway	metabolic Serine Metabolism Saccharomyces cerevisiae The biosynthesis of serine begins with 3-phospho-D-glycerate being metabolize into 3-phosphohydroxypyruvate through a 3-phosphoglycerate dehydrogenase. The resulting compound 3-phosphohydroxypyruvate is transaminated into 3-phospho-L-serine through a phosphoserine transaminase. This is followed by 3-phospho-L-serine being dephosphorylated through a phosphoserine phosphatase resulting in the release of a phosphate and Serine. Serine can also be incorporated into the mitochondrion and then serine can then be used to synthesize glycine through a mitochondrial serine hydroxymethyltransferase. Glycine is then used to synthesize formic acid by first being metabolized into 5,10 methylene THF, which is transformed into a 5,10 methenyltetrahydrofolate , followed by an N10 formyl tetrahydrofolate and lastly formic acid, all through a mitochondrial C1-tetrahydrofolate synthase. In the cytosol serine can either be degraded to synthesize glycine through a serine hydroxymethyltransferase or it can be degraded into 2-aminoprop-2-enoate. The latter compound can be spontaneously be converted first into 2-iminopropanoate and this compound is then converted into pyruvic acid. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: January 07, 2016 at 11:26 Last Updated: January 07, 2016 at 11:26
PW002553 View Pathway	metabolic Serine Metabolism Arabidopsis thaliana The biosynthesis of serine begins in the chloroplast with 3-phospho-D-glycerate being metabolize into 3-phosphohydroxypyruvate through a 3-phosphoglycerate dehydrogenase. The resulting compound 3-phosphohydroxypyruvate is transaminated into 3-phospho-L-serine through a phosphoserine transaminase. This is followed by 3-phospho-L-serine being dephosphorylated through a phosphoserine phosphatase resulting in the release of a phosphate and Serine. Serine can also be incorporated into the mitochondrion and then serine can then be used to synthesize glycine through a mitochondrial serine hydroxymethyltransferase. Glycine is then used to synthesize formic acid by first being metabolized into 5,10 methylene THF, which is transformed into a 5,10 methenyltetrahydrofolate , followed by an N10 formyl tetrahydrofolate and lastly formic acid, all through a mitochondrial C1-tetrahydrofolate synthase. It can also be used in tryptophan biosynthesis, glycine biosynthesis and cysteine biosynthesis BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: May 20, 2016 at 13:10 Last Updated: May 20, 2016 at 13:10
PW126971 View Pathway	drug action Sertaconazole Action Pathway Homo sapiens Sertaconazole is a topical antifungal agent used to treat interdigital tinea pedis (athelete's foot) in immunocompromised patients. Sertaconazole inhibits lanosterol 14-alpha demethylase in the endoplasmic reticulum of fungal cells. Lanosterol 14-alpha demethylase is the enzyme that catalyzes the synthesis of 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol from lanosterol. With this enzyme inhibited ergosterol synthesis cannot occur which causes a significant low concentration of ergosterol in the fungal cell. Ergosterol is essential in maintaining membrane integrity in fungi. Without ergosterol, the fungus cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells. This leads to cell lysis which causes it to collapse and die. Sertaconazole might also inhibit endogenous respiration, interact with membrane phospholipids, inhibit transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: June 02, 2022 at 14:51 Last Updated: June 02, 2022 at 14:51
PW145241 View Pathway	drug action Sertaconazole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:23 Last Updated: October 07, 2023 at 15:23
PW176403 View Pathway	metabolic Sertaconazole Predicted Metabolism Pathway Homo sapiens Metabolites of Sertaconazole are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 16:52 Last Updated: December 07, 2023 at 16:52
PW145657 View Pathway	drug action Sertindole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:19 Last Updated: October 07, 2023 at 16:19
PW176355 View Pathway	metabolic Sertindole Predicted Metabolism Pathway Homo sapiens Metabolites of sildenafil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:29 Last Updated: December 07, 2023 at 15:29
PW126521 View Pathway	drug action Sertraline Action Pathway (New) Homo sapiens Sertraline is a selective serotonin reuptake inhibitor (SSRI) indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD). Common off-label uses for sertraline include the prevention of post stroke depression, generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neurocardiogenic syncope. It's mechanism of action it to bind selectively bind to the sodium dependent serotonin transporter and blocking the recycling of serotonin from the synapse. As serotonin accumulates it enhances the serotonergic function of the 5-hydroxytryptamine 1A receptor leading to decreased anxiety and depressive moods. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: December 23, 2021 at 14:36 Last Updated: December 23, 2021 at 14:36
PW145193 View Pathway	drug action Sertraline Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:16 Last Updated: October 07, 2023 at 15:16
PW127973 View Pathway	drug action Sertraline Mechanism of Action Action Pathway (New) Homo sapiens Sertraline is a selective serotonin reuptake inhibitor (SSRI) indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD). Common off-label uses for sertraline include the prevention of post stroke depression, generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neuro cardiogenic syncope. Sertraline also has minimal effects on norepinephrine and dopamine uptake, and research has shown that it has more dopaminergic activity than other medications in the same SSRI class. Sertraline binds selectively bind to the sodium dependent serotonin transporter and blocks the recycling of serotonin from the synapse. As serotonin accumulates it enhances the serotonergic function of the 5-hydroxytryptamine 1A receptor leading to decreased anxiety and depressive moods. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: June 26, 2023 at 11:05 Last Updated: June 26, 2023 at 11:05