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Matched Description: Nabumetone (also named Relafen and Relifex) is a nonsteroidal anti-inflammatory drug (NSAID). It … can be used to relieve pain (analgesic) and reduce fever (antipyretic). Nabumetone can block … prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H … synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin … the process of inflammation; hence, inhibition of prostaglandin synthesis can reduce the pain, fever and inflammation.

Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

Matched Description: arthritis and osteoarthritis. Most NSAIDs are non-selective prostaglandin G/H synthase (a.k.a … . cyclooxygenase or COX) inhibitors that act on both prostaglandin G/H synthase 1 and 2 (COX-1 and -2 … involved in fever, pain, swelling, inflammation, and platelet aggregation. NSAIDs antagonize COX by … entering the active site. The analgesic, antipyretic and anti-inflammatory effects of NSAIDs occur as a … -1. The first part of this figure depicts the anti-inflammatory, analgesic and antipyretic pathway

Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

Matched Description: typically used to treat conditions associated with pain and inflammation, such as rheumatoid arthritis … , headaches or migraines, and dysmenorrhoea. Sulindac is believed to be a non-selective NSAID, meaning … that it inhibits both prostaglandin G/H synthase 1 and 2 (COX-1 and COX-2). In this pathway … of sulindac, which then inhibits the COX-1 and COX-2 enzymes. These enzymes are normally responsible … H2 from prostaglandin G2. These prostaglandins are responsible for inflammation and fever, as well

Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

Matched Description: (NSAID). It can be used to treat pain and inflammation that is associated with cataract surgery … 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and

Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

Matched Description: reduce pain, swelling, tenderness, and stiffness. Tolmetin can block prostaglandin synthesis by the … action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 … catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2

Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

Matched Description: inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze the … arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the

Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

Matched Description: reduce pain and fever. Salicylic acid can block prostaglandin synthesis by the action of inhibition of … prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic … acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism

Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

Matched Description: Cyclophosphamide is an antineoplastic alkylating agent used to treat lymphoma and leukemia … order to be activated by various enzymes and cytochrome p450 isoforms (2A6, 2B6, 3A4, 2C9, 2C18, 2C19 … degraded into acrolein and carboxyphosphamide but more importantly it turns into phosphoramide … trying to replace the alkylated bases with new ones. This prevents DNA synthesis and RNA … transcription as the DNA is damaged and cannot be read properly. Phosphoramide mustard also works by creating

Matched Protein Synonyms: Cytochrome P450 MP-20

Matched Compound Synonyms: [oh(oh)] … Magnacide h and b

Matched Description: isozymes in the liver. 4-Hydroxyphosphamide is more soluble than cyclophosphamide and is the primary form … cancer cell and spontaneuosly forms aldophosphamide. This is a reversible reaction. Aldophosphamide can … decompose into acrolein and phosphoramide mustard. Phosphoramide mustard is the active alkylating … agent and forms alkyl adducts with DNA through a phosphoramide aziridinium intermediate. Alkylation … of DNA causes DNA damage and eventually cell death.

Matched Protein Synonyms: Cytochrome P450 MP-20

Matched Compound Synonyms: Magnacide h and b … [oh(oh)]

Matched Compound Synonyms: Omebeta 20 … Omebeta 20 … Omebeta 20 … Omebeta 20 … Rat and mice bait