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Matched Description: PHD1,2 and 3, (also known as EglN2,1 and 3). Under hypoxic conditions, HIF alpha escapes … hydroxylation and degration. Fumarate hydratase (FH) is a housekeeping gene, but mutations in this gene allows … for fumarate to accumulate and cross the mitochondrial barrier through a dicarboxylate carrier. Once … in the cytosol, it inhibits the activity of the PHD1,2 and 3 since it is chemically similar to

Matched Protein Synonyms: SM-20 … F-box and leucine-rich repeat protein 11

Matched Compound Synonyms: [co2(oh)](-)

Matched Description: -steroidal anti-inflammatory drug (NSAID). It is used to treat pain and inflammation in many conditions … (COX-1) and prostaglandin G/H synthase-2 (COX-2) in the cyclooxygenase pathway. The cyclooxygenase … , and during inflammation, it is responsible for prostaglandin synthesis. It leads to the formation … immune cells and for increasing pain sensation by acting on pain fibers. Dexibuprofen inhibits the … action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of

Matched Compound Synonyms: Fa(20:4(5z,8z,11z,14z)) … proposed to be more pharmacologically active and tolerable with a better safety profile than … the simulated gastric and enteric juices compared with the racemic ibuprofen and displays improved oral bioavilability. … proposed to be more pharmacologically active and tolerable with a better safety profile than … the simulated gastric and enteric juices compared with the racemic ibuprofen and displays improved oral bioavilability.

Matched Description: Beta-oxidation is the major degradative pathway for fatty acid esters in humans. Fatty acids and … , regulators of enzymes and membrane channels, ligands for nuclear receptors, precursor molecules for … hormones, and signalling molecules. Beta-oxidation occurs in the peroxisomes and mitochondria, the … -CoA in the peroxisomes and then transported to the mitochondria for the remainder of the oxidation … -CoA. Short and medium chain fatty acids can enter the mitochondria directly via diffusion where they

Matched Protein Synonyms: Solute carrier family 25 member 20 … Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase … Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase … Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase

Matched Compound Synonyms: Acetoxyl 2.5 and 5 … Dry and clear … Lucidol g 20 … Mixture of dibenzoyl peroxide and calcium sulfate … Mixture of dibenzoyl peroxide and calcium sulphate

Matched Description: cholesterol. Aldosterone then goes to act on the distal convoluted tubule and the collecting duct to make … regulating fluid homeostasis and blood pressure. It is involved in various means to increase the body's … blood pressure, hence why it is a target for many pharmceutical drugs that treat hypertension and … vasoconstriction and a subsequent increase in blood pressure. However, it can also influence the blood pressure … in the supraoptic nuclei and they travel down the neurosecretory neuron axon to be stored in the

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive angiotensin … enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can … also be used in the treatment of congestive heart failure and type II diabetes. Temocapril is a … vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and increase … bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure.

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive … enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug … can also be used in the treatment of congestive heart failure and type II diabetes. Fosinopril is a … vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and … increase bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure.

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive angiotensin I … enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can … also be used in the treatment of congestive heart failure and type II diabetes. Spirapril is a … vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and increase … bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure.

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: reabsorption and peripheral resistance (that will lead to increasing blood pressure) via aldosterone secretion … decreasing blood pressure. For more information on the effects of aldosterone on electrolyte and water … describes the mechanism of direct aldosterone antagonists. Telmisartan is an effective agent for reducing … blood pressure and may be used to treat essential hypertension and heart failure.

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive angiotensin I … enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can … also be used in the treatment of congestive heart failure and type II diabetes. Enalapril is a … vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and increase … bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure.

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone