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Matched Description: Fatty acids and their CoA byproducts can be found in many places in the body, playing major roles … in many basic functions of the body. These include signalling roles, energy creation roles and … enzyme regulation. Beta-oxidation is a process that occurs in the peroxisomes and in the mitochondria … -CoA thiolase to create acetyl-CoA (necessary for the citric acid cycle) and uses trifunctional enzyme … subunits alpha and beta to create palmityl-CoA. This palmityl-CoA is then converted by long-chain

Matched Protein Synonyms: Solute carrier family 25 member 20 … Solute carrier family 25 member 20 … Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase … Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase … Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase

Matched Compound Synonyms: Carnipass 20 … Carnipass 20

Matched Description: Phenylketonuria, also called Folling disease, is a rare inborn error of metabolism (IEM) and … disorder is characterized by a large accumulation of phenylalanine in the blood and other tissues. It is … , Phenylacetylglutamine, and Glycine in the blood and urine. Symptoms of the disorder include behavioural … problems, psychiatric disorders and seizures. Treatment eating a diet limiting the intake of

Matched Proteins: Sodium- and chloride-dependent creatine transporter 1

Matched Compound Synonyms: 2-oxo-3-phenylpropanoic acid (mixture oxo and keto) … Ammonia (conc 20% or greater) … [oh(oh)] … Ammonia (conc 20% or greater) … [oh(oh)]

Matched Description: PHD1,2 and 3, (also known as EglN2,1 and 3). Under hypoxic conditions, HIF alpha escapes … hydroxylation and degration. Succinate dehydrogenase (SDH) is a collection of housekeeping genes (SDHA,B,C,D … ), but mutations in those genes allows for succinate to accumulate and cross the mitochondrial barrier … through a dicarboxylate carrier. Once in the cytosol, it inhibits the activity of the PHD1,2 and 3

Matched Protein Synonyms: F-box and leucine-rich repeat protein 11 … SM-20

Matched Compound Synonyms: [co2(oh)](-)

Matched Description: Beta-oxidation is the major degradative pathway for fatty acid esters in humans. Fatty acids and … , regulators of enzymes and membrane channels, ligands for nuclear receptors, precursor molecules for … hormones, and signalling molecules. Beta-oxidation occurs in the peroxisomes and mitochondria, the … -CoA in the peroxisomes and then transported to the mitochondria for the remainder of the oxidation … -CoA. Short and medium chain fatty acids can enter the mitochondria directly via diffusion where they

Matched Protein Synonyms: Solute carrier family 25 member 20 … Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase … Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase … Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase

Matched Description: isozymes in the liver. 4-Hydroxyphosphamide is more soluble than cyclophosphamide and is the primary form … cancer cell and spontaneuosly forms aldophosphamide. This is a reversible reaction. Aldophosphamide can … decompose into acrolein and phosphoramide mustard. Phosphoramide mustard is the active alkylating … agent and forms alkyl adducts with DNA through a phosphoramide aziridinium intermediate. Alkylation … of DNA causes DNA damage and eventually cell death.

Matched Protein Synonyms: Cytochrome P450 MP-20

Matched Compound Synonyms: Magnacide h and b … [oh(oh)]

Matched Description: liver. 4-Hydroxyifosfamide crosses the plasma membrane of the cancer cell and spontaneuosly forms … aldoifosfamide. This is a reversible reaction. Aldoifosfamide can decompose into acrolein and ifosforamide … mustard. Ifosforamide mustard is the active alkylating agent and forms alkyl adducts with DNA … through an ifosforamide aziridinium intermediate. Alkylation of DNA causes DNA damage and ultimately cell death.

Matched Protein Synonyms: Cytochrome P450 MP-20

Matched Compound Synonyms: Magnacide h and b … [oh(oh)]

Matched Description: PHD1,2 and 3, (also known as EglN2,1 and 3). Under hypoxic conditions, HIF alpha escapes … hydroxylation and degration. Fumarate hydratase (FH) is a housekeeping gene, but mutations in this gene allows … for fumarate to accumulate and cross the mitochondrial barrier through a dicarboxylate carrier. Once … in the cytosol, it inhibits the activity of the PHD1,2 and 3 since it is chemically similar to

Matched Protein Synonyms: SM-20 … F-box and leucine-rich repeat protein 11

Matched Compound Synonyms: [co2(oh)](-)

Matched Description: liver. 4-Hydroxyifosfamide crosses the plasma membrane of the cancer cell and spontaneuosly forms … aldoifosfamide. This is a reversible reaction. Aldoifosfamide can decompose into acrolein and ifosforamide … mustard. Ifosforamide mustard is the active alkylating agent and forms alkyl adducts with DNA … through an ifosforamide aziridinium intermediate. Alkylation of DNA causes DNA damage and ultimately cell death.

Matched Protein Synonyms: Cytochrome P450 MP-20

Matched Compound Synonyms: Magnacide h and b … [oh(oh)]

Matched Description: Cyclophosphamide is an antineoplastic alkylating agent used to treat lymphoma and leukemia … order to be activated by various enzymes and cytochrome p450 isoforms (2A6, 2B6, 3A4, 2C9, 2C18, 2C19 … degraded into acrolein and carboxyphosphamide but more importantly it turns into phosphoramide … trying to replace the alkylated bases with new ones. This prevents DNA synthesis and RNA … transcription as the DNA is damaged and cannot be read properly. Phosphoramide mustard also works by creating

Matched Protein Synonyms: Cytochrome P450 MP-20

Matched Compound Synonyms: [oh(oh)] … Magnacide h and b

Matched Description: Brexanolone can be found under the brand name Zulresso, and it is the first drug to have ever been … , worthlessness or guilt, cognitive impairment, and/or possibly suicidal ideation, it is considered a life … effects on the maternal-infant bond and later infant development. The development and availability … of brexanolone for the treatment of PPD in adult females subsequently provides a new and promising … anti-depressive medications elicit actions that may modulate the presence and activity of

Matched Protein Synonyms: GABA and glycine transporter

Matched Compound Synonyms: 3alpha-oh dhp … Allopregnan-3alpha-ol-20-one … (3a,5a)-3-hydroxypregnan-20-one … (3α,5α)-3-hydroxypregnan-20-one … (+)-3a-hydroxy-5a-pregnan-20-one