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Matched Description: an agonist of mu, kappa, and delta opioid receptors. Mu-binding sites are discretely distributed in … the brain, spinal cord, and other tissues. It exerts its principal pharmacologic effects on the … central nervous system. Its primary actions of therapeutic value are analgesia and sedation … . Ketobemidone also depresses the respiratory centers, depresses the cough reflex, and constricts the pupils … . Ketobemidone binds very strongly to mu opioid receptors and acts as a competitive agonist. Opiate

Matched Description: disease and Factor XIII deficiency. Antihemophilic factor, human recombinant is administered … intravenously and acts to correct coagulation defects, by activating coagulation factor X and IX.

Matched Description: Pseudouridine is phosphorylated by interacting with atp and a psuK resulting in the release of an … ADP, a hydrogen ion and a pseudouridine 5'-phosphate. The latter compound then reacts with water … through a pseudouridine 5'-phosphate glycosidase resulting in the release of a uracil and D-ribofuranose 5-phosphate

Matched Description: The DNA replication (dnaTC) operon is a bicistronic operon consisting of dnaC and dnaT. This operon … is regulated by a rho-independent terminator. The product of dnaC and dnaT are respectively … primosomal protein 1 and DNA replication protein DnaC. DnaT is also responsible for inducting replication of stable DNA during SOS response.

Matched Description: -adrenergic receptors and beta2-adrenergic receptors. Blocking of beta1-adrenergic receptors in heart and … vascular smooth muscle can lead to reduced heart rate, cardiac output, and decreased blood pressure

Matched Description: Ketone bodies are three water-soluble molecules (acetoacetate, beta-hydroxybutyrate, and the … the liver from fatty acids. Ketone bodies are readily transported into tissues outside the liver and … converted into acetyl-CoA, which then enters the citric acid cycle and is oxidized in the … produce CoA and acetoacetyl-CoA. This is a bi-directional reaction occurring in the mitochondrion … -3-methylglutaryl-CoA and CoA are catalyzed by hydroxymethylglutaryl-CoA synthase to produce

Matched Description: absorbed and can travel across membranes even the blood-brain barrier. Physostigmine acts on the … acetylcholinesterase enzyme and inhibits it so it cannot break down acetylcholine. By doing so it … keeps acetylcholine available within the synaptic cleft continuing to act on nicotinic and muscarinic receptors.

Matched Description: eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group … has been replaced by a benzimidazol-2-on-1-yl group. It is a butyrophenone derivative and dopamine … antagonist used to prevent and treat postoperative nausea and vomiting. Droperidol is used to … produce tranquilization and to reduce the incidence of nausea and vomiting in surgical and diagnostic … procedures. Droperidol causes a CNS depression at subcortical levels of the brain, midbrain, and

Matched Description: Methylergometrine is a semisynthetic ergot alkaloid and a derivative of ergonovine. It is also … known as methylergonovine. Methylergometrine acts directly on the smooth muscle of the uterus and … increases the tone, rate, and amplitude of rhythmic contractions through binding and the resultant … antagonism of the dopamine D1 receptor. Thus, it induces a rapid and sustained tetanic uterotonic effect … which shortens the third stage of labor and reduces blood loss. It is used for the prevention and

Matched Description: Melanin is the term used for multiple pigments found in many organisms, and specifically our skin … , hair and iris tissues. There are three types of melanin, eumelanin, pheomelanin and neuromelanin … . Eumelanin is the most common, and can be brown or black. Melanin is produced by melanocytes, and is a … and proportions of components. To begin, this pathway takes L-dopachrome from the L-dopa and L … -dopachrome biosynthesis pathways and, in the melanosome, it can either spontaneously form 5,6