Browsing Search Results

Matched Description: Triprolidine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms … such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting … and are administered to attenuate inflammatory process in order to treat conditions such as … allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 receptors in T-cells … to inhibit the immune response, in blood vessels to constrict dilated blood vessels, and in smooth

Matched Description: -like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3, and H4 … . Histamine receptor H1 belongs to the family of G-protein-coupled receptors (GPCRs), and it is … expressed in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous … system. It is linked to an intracellular G-protein (Gαq) that activates phospholipase C and the … release and expression of the NF-κB immune response transcription factor. H1-antihistamines inactivate

Matched Description: is used as a bronchodilator for the treatment of asthma and relief from bronchospasm. The result of … taking this drug is relaxation of the bronchial smooth muscles causing bronchodilaton and increased … airflow. Once pirbuterol is administered and it binds to the beta-2 adrenergic receptor, the G … protein signalling cascade begins. The alpha and beta/gamma subunits of the G protein separate and GDP … and inhibits MLCK through decreased calcium levels causing muscle relaxation. PKA can phosphorylate

Matched Description: and chronic bronchitis. It accomplishes this by upon inhalation of the drug by relaxing smooth … muscles in the airways to improve breathing. It can be found under the brand name Brovana, and it has a … 2 fold greater potency than racemic formoterol. Once arformoterol is administered and it binds to … the beta-2 adrenergic receptor, the G protein signalling cascade begins. The alpha and beta/gamma … subunits of the G protein separate and GDP is replaced with GTP on the alpha subunit. This alpha subunit

Matched Description: Dexchlorpheniramine maleate is a first generation H1-antihistamine used to treat allergic and … vasomotor rhinitis, allergic conjunctivitis, and mild urticaria and angioedema. H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and … vessels to constrict dilated blood vessels, and in smooth muscles of lungs and intestines to relax

Matched Description: key step in proper circadian rhythm. Heterodimerization of clock proteins PER and CRY is required for … (CK1). Once in the nucleus, PER and CRY proteins appear to differentially inhibit the transactivation … by CLOCK/BMAL1. Proteins like REV-ERBa and DEC also regulate the transcriptional activation by CLOCK … /BMAL1. In addition, CRY, PER, and BMAL1-CLOCK play bidirectional roles in transcription resulting in … interactivating feedback loops. The expression of BMAL1 and CLOCK can be upregulated by CRY and PER

Matched Description: key step in proper circadian rhythm. Heterodimerization of clock proteins PER and CRY is required for … (CK1). Once in the nucleus, PER and CRY proteins appear to differentially inhibit the transactivation … by CLOCK/BMAL1. Proteins like REV-ERBa and DEC also regulate the transcriptional activation by CLOCK … /BMAL1. In addition, CRY, PER, and BMAL1-CLOCK play bidirectional roles in transcription resulting in … interactivating feedback loops. The expression of BMAL1 and CLOCK can be upregulated by CRY and PER

Matched Description: of energy and inhibits the breakdown of high energy metabolites. Glycogen and lipid biosynthesis are … upregulated, and conversely, glycogen and fatty acid metabolism are down-regulated. Insulin also … modulates transcription and translation. Binding of insulin to the insulin receptor (IR) results in … activation leads to the activation of H-Ras, MAPK1-3, and PI3-kinase pathways. The activation of these … pathways leads to modulation of key proteins in glycogen metabolism/lipid metabolism and transcription/translation.

Matched Description: of energy and inhibits the breakdown of high energy metabolites. Glycogen and lipid biosynthesis are … upregulated, and conversely, glycogen and fatty acid metabolism are down-regulated. Insulin also … modulates transcription and translation. Binding of insulin to the insulin receptor (IR) results in … activation leads to the activation of H-Ras, MAPK1-3, and PI3-kinase pathways. The activation of these … pathways leads to modulation of key proteins in glycogen metabolism/lipid metabolism and transcription/translation.

Matched Description: -threonine interacts with a threonine dehydratase biosynthetic releasing water, a hydrogen ion and (2Z)-2 … -aminobut-2-enoate. This compound is isomerized into a 2-iminobutanoate which interacts with water and a … hydrogen ion spontaneously, resulting in the release of ammonium and 2-ketobutyric acid. This … compound reacts with pyruvic acid and hydrogen ion through an acetohydroxybutanoate synthase … / acetolactate synthase 2 resulting in carbon dioxide and (S)-2-Aceto-2-hydroxybutanoic acid. The latter