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Matched Description: It was first authorized for use in the US in November 2001 and in Europe in April 2002. Shown to be … effective against a wide range of Gram-positive and Gram-negative aerobic and anaerobic bacteria … action. It works by binding to and inhibiting bacterial penicillin-binding proteins (PBPs).5 In … Escherichia coli, it has a strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preferential binding … to PBPs 2 and 3.5 Upon binding to PBPs, ertapenem inhibits bacterial cell wall synthesis by

Matched Description: was first authorized for use in the US in November 2001 and in Europe in April 2002. Shown to be … effective against a wide range of Gram-positive and Gram-negative aerobic and anaerobic bacteria … . It works by binding to and inhibiting bacterial penicillin-binding proteins (PBPs).5 In Escherichia … coli, it has a strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preferential binding to PBPs 2 … and 3.5 Upon binding to PBPs, ertapenem inhibits bacterial cell wall synthesis by interfering with

Matched Description: pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor … agonist which means it reduces sympathetic nervous system tone, and causes respiratory depression and … G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface … voltage-operated calcium channels and open calcium-dependent inwardly rectifying potassium channels … . This results in hyperpolarization and reduced neuronal excitability. Remifentanil acts at A delta

Matched Description: treatment of colon cancer and minimal residual disease. Piritramide binds to mu, kappa, and delta … -protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the … , and noradrenaline is inhibited. Opioids close N-type voltage-operated calcium channels and open … calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization and reduced … neuronal excitability. Morphine acts at A delta and C pain fibres in the dorsal horn of the spinal

Matched Description: Celiprolol is a beta-blocker for the management of hypertension and angina pectoris. It is … simultaneously a selective β1 receptor antagonist, a β2 receptor partial agonist and a weak α2 receptor … lowers blood pressure in hypertensive patients at rest and on exercise. The effects on heart rate and … conditions of stress such as exercise, celiprolol attenuates chronotropic and inotropic responses to … calcium and muscle relaxation, therefore altering the heart rate. Celiprolol is administered as an

Matched Description: clinically as an antihypertensive. It is selective for vasculature and does not produce effects on the … opening of voltage dependent calcium channels and an influx of calcium into the cell ultimately … producing contraction. Manidipine binds to and dissociates slowly from L- and T-type voltage dependent … calcium channels on smooth muscle cells, blocking the entrance of extracellular calcium into the cell and … produces renal vasodilation and an increase in natriuresis. This likely contributes to the

Matched Description: episodes of psychotic disorders. It can also be used to control severe nausea and vomiting, severe … hiccups, and moderate to severe pain in some hospitalized patients. Triflupromazine acts on the central … dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone (CTZ) and vomiting centre … . Triflupromazine blocks the neurotransmitter dopamine and the vagus nerve in the gastrointestinal tract … . Triflupromazine also binds the muscarinic acetylcholine receptors (M1 and M2) and the tryptamine D

Matched Description: Edoxaban is a novel oral anticoagulant, used to prevent or reduce the risk of stroke and systemic … cannot occur and stops the clotting cascade from proceeding. Metabolized minimally by hydrolysis in … the liver and primarily eliminated through the urine. Edoxaban increases the risk of major bleeding … such as intracranial hemorrhage and gastrointestinal bleeding. Edoxaban should not be co … . Due to the anticoagulant properties herbs and supplements with anticoagulant and antiplatelet

Matched Description: was first authorized for use in the US in November 2001 and in Europe in April 2002. Shown to be … effective against a wide range of Gram-positive and Gram-negative aerobic and anaerobic bacteria … . It works by binding to and inhibiting bacterial penicillin-binding proteins (PBPs).5 In Escherichia … coli, it has a strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preferential binding to PBPs … 2 and 3.5 Upon binding to PBPs, ertapenem inhibits bacterial cell wall synthesis by interfering with

Matched Description: cells tend to overexpress VEGF, which stimulates angiogenesis, facilitating cancer growth and … endothelial cell surfaces. Upon binding, the receptor autophosphorylates and initiates a signalling … MAP kinase kinase, which phosphorylates MAP kinase. The activated MAP kinase enters the nucleus and … , migration, permeability, invasion, and survival. Binding of VEGF to VEGFR-2 also activates phospholipase C … PIP2 into DAG and IP3. DAG may be involved in the activation of Raf-1 leading to angiogenesis