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Matched Description: Procaterol is a beta-2 adrenergic agonist that is used as a bronchodilator. It is a long acting and … potent drug that can be taken orally or through inhalation for the treatment of asthma and COPD … administered and it binds to the beta-2 adrenergic receptor, the G protein signalling cascade begins. The alpha … and beta/gamma subunits of the G protein separate and GDP is replaced with GTP on the alpha subunit … protein kinase A (PKA) which in turn phosphorylates targets and inhibits MLCK through decreased

Matched Description: Buclizine is an antihistamine and antiemetic drug for the treatment of allergy symptoms and … prevention of nausea and vomiting. H1-antihistamines interfere with the agonist action of histamine at the … H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such … as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 receptors … in T-cells to inhibit the immune response, in blood vessels to constrict dilated blood vessels, and

Matched Description: -like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3, and H4 … . Histamine receptor H1 belongs to the family of G-protein-coupled receptors (GPCRs), and it is … expressed in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous … system. It is linked to an intracellular G-protein (Gαq) that activates phospholipase C and the … release and expression of the NF-κB immune response transcription factor. H1-antihistamines inactivate

Matched Description: -like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3, and H4 … . Histamine receptor H1 belongs to the family of G-protein-coupled receptors (GPCRs), and it is … expressed in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous … system. It is linked to an intracellular G-protein (Gαq) that activates phospholipase C and the … release and expression of the NF-κB immune response transcription factor. H1-antihistamines inactivate

Matched Description: Dimenhydrinate is an H1-antihistamine and medication used to prevent and treat nausea, vomiting … , vertigo, and motion sickness.. H1-antihistamines interfere with the agonist action of histamine at the … H1 receptor and are administered to attenuate inflammatory process in order to treat conditions … such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 … , and in smooth muscles of lungs and intestines to relax those muscles. H1-antihistamines interfere

Matched Description: Clenbuterol is a beta-2 adrenergic agonist used as a bronchodilator. This drug is taken orally and … is used for the treatment of asthma, bronchitis, and COPD. It exerts its effect through activation … signalling. Once clenbuterol is administered and it binds to the beta-2 adrenergic receptor, the G protein … signalling cascade begins. The alpha and beta/gamma subunits of the G protein separate and GDP is … and inhibits MLCK through decreased calcium levels causing muscle relaxation. PKA can phosphorylate

Matched Description: Tipranavir is a sulfonamide-containing dyhydropyrone and a nonpeptidic protease inhibitor used to … in combination with at least two other anti-HIV drugs. The HIV virus binds and penetrates the host … nucleus and is integrated into the host DNA via integrase. The DNA is then transcribed, creating viral … the Gag-pol polyprotein, where Gag encodes for the capsid and matrix protein to form the outer … protein shell, and Pol encodes for the reverse transcriptase and integrase protein to synthesize and

Matched Description: combination with other antiviral drugs in the treatment of HIV in both adults and children. The HIV … virus binds and penetrates the host cell. Viral RNA is transcribed into viral DNA via reverse … transcriptase. Viral DNA enters the host nucleus and is integrated into the host DNA via integrase. The DNA … protease is synthesized as part of the Gag-pol polyprotein, where Gag encodes for the capsid and … matrix protein to form the outer protein shell, and Pol encodes for the reverse transcriptase and

Matched Description: of vasospastic angina, chronic stable angina and hypertension. Nilvadipine is similar to other … dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nilvadipine is used to … treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By … blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the … systemic arteries, results in an increase of myocardial oxygen supply and a decrease in systemic

Matched Description: through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. In … bronchial and vascular smooth muscle, acebutolol can compete with epinephrine for beta-2 adrenergic … synthesis, which in turn activates PKA production, which then activates SRC and nitric oxide synthase, its … inhibition causes the inhibition of cAMP, PKA, SRC and nitric oxide synthase signaling. Following … , the inhibition of SRC in essence causes the activation of Caspase 3 and Caspase 9. This Caspase