SMP0174915
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Acrivastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: such as sneezing, rhinorrhea, pruritus, lacrimation, and nasal congestion. H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and … vessels to constrict dilated blood vessels, and in smooth muscles of lungs and intestines to relax … and are administered to attenuate inflammatory process in order to treat conditions such as allergic
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SMP0174912
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Antazoline H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: Antazoline is an antihistamine agent used for the symptomatic treatment of nasal congestion and … receptor and are administered to attenuate inflammatory process in order to treat conditions such as … allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 receptors in T … -cells to inhibit the immune response, in blood vessels to constrict dilated blood vessels, and in … smooth muscles of lungs and intestines to relax those muscles.
H1-antihistamines interfere with the
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SMP0174907
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Pheniramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: Pheniramine is an antihistamine used to treat allergic rhinitis and pruritus. H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … , and urticaria. H1-antihistamines act on H1 receptors in T-cells to inhibit the immune response, in … blood vessels to constrict dilated blood vessels, and in smooth muscles of lungs and intestines to … receptor and are administered to attenuate inflammatory process in order to treat conditions such as
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SMP0124522
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Carvedilol Action Pathway
Homo sapiens
Matched Description: through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes … . Carvedilol is a racemic mixture where the S(-) enantiomer is a beta adrenoceptor blocker and the R … (+) enantiomer is both a beta and alpha-1 adrenoceptor blocker. In bronchial and vascular smooth … production, which then activates SRC and nitric oxide synthase, its inhibition causes the inhibition … of cAMP, PKA, SRC and nitric oxide synthase signaling. Following this chain of reactions, we see
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SMP0126187
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Bopindolol Action Pathway (New)
Homo sapiens
Matched Description: Bopindolol is a non-cardioselective beta blocker and the ester prodrug of pinolol. It can be … administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and … travels to act on cardiomyocytes. In bronchial and vascular smooth muscle, bopindolol can compete with … activates SRC and nitric oxide synthase, its inhibition causes the inhibition of cAMP, PKA, SRC and nitric … Caspase 3 and Caspase 9. This Caspase cascade leads to cell apoptosis. The net result of all these
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SMP0174910
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Mepyramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: , hypersensitivity reactions, and pruritic skin disorders. H1-antihistamines interfere with the agonist action of … histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat … conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act … blood vessels, and in smooth muscles of lungs and intestines to relax those muscles.
H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate
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SMP0174937
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Cetirizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: Cetirizine is a selective Histamine-1 antagonist drug used in allergic rhinitis and chronic … urticaria. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are … , allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 receptors in T-cells to inhibit … the immune response, in blood vessels to constrict dilated blood vessels, and in smooth muscles of … lungs and intestines to relax those muscles.
H1-antihistamines interfere with the agonist action of
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SMP0012048
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Glycine Betaine Biosynthesis II
Arabidopsis thaliana
Matched Description: Glycine betaine biosynthesis I, beginning in the cytosol and ending in the peroxisome results in … osmotic stress, mutagenesis, and radiation-induced damage. First, serine decarboxylase (SDC) uses a … proton and a pyridoxal 5'-phosphate cofactor to catalyze the conversion of L-serine to ethanolamine … -phosphoethanolamine. Note that this is only the probable ethanolamine kinase in Arabidopsis thaliana and … requires further research to confirm its function. Steps 3, 4, and 5 are catalyzed by
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SMP0000668
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Bevantolol Action Pathway
Homo sapiens
Matched Description: treat angina pectoris and hypertension. Bevantolol is an antagonist of beta-1 adrenoreceptors to … block the G protein signalling cascade and inhibit epinephrine induced sympathetic activation such as … stimulate beta-adrenergic receptors. This results in a decrease in preload and blood pressure.
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SMP0002017
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Ketogluconate Metabolism
Escherichia coli
Matched Description: through a NADPH dependent 2,5-diketo-D-gluconate reductase resulting in the release of a NADP and 5 … resulting in the release of a NADP and a 2-keto-L-gulonate. The 2-keto-L-gulonate interacts with a NADPH 2 … -keto-L-gulonate reductase resulting in a NADP and a L-idonate. The L-idonate interacts with a NADP L … -idonate 5-dehydrogenase resulting in the release of hydrogen ion, a NADPH and a 5-dehydro-D … in the release of a NADP and a D-gluconate.
The other way to produce D-gluconate is by having 2,5
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