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Matched Description: The TOR signalling pathway is responsible for the cellular reactions towards nutrient and energy … availability and hypoxia/stress. When TOR1/2 is activated, it activates TAP42 which in turn can … -Gln3 complex and the separation of Ure2 and Gln3. Gln3 then gets incorporated into the nucleus

Matched Description: the cytochrome CYP3A4 and CYP2B6 to form N-Desmethyltramadol, which further metabolized to N,N … -Didesmethyltramadol through CYP3A4 and CYP2B6 and to N,O-Didesmethyltramadol through CYP2D6. The O … metabolized to O-Desmethyltramadol glucuronide through UDP-glucuronosyltransferase 2B7 and UDP

Matched Description: pathway of choline biosynthesis. First, serine decarboxylase (SDC) uses a proton and a pyridoxal 5 … that this is only the probable ethanolamine kinase in Arabidopsis thaliana and requires further … research to confirm its function. Steps 3, 4, and 5 are catalyzed by phosphoethanolamine N … phosphocholine and utilize S-adenosyl-L-methionine as a methyl donor. The intermediates are as follows: O … -Phosphoethanolamine, N-methylethanolamine phosphate, and N-dimethylethanolamine phosphate. Sixth

Matched Description: Globoid Cell Leukodistrophy (GLD), also called Krabbe disease and galactosylceramide lipidosis, is … population and a worldwide incidence of 1/100,000-1/250,000 live births. GLD is an autosomal recessive … is a lysosomal protein that hydrolyzes the galactose ester bonds of ceramides and ceramide … derivatives including galactocerebroside, galactosylsphingosine (psychosine), lactosylceramide, and … catabolism (via the removal of galactose) of galactosylceramide, a major lipid in myelin, kidney, and

Matched Description: cancer, pancreatic cancer, breast cancer, and cervical cancer. As a cream, it is used for actinic … keratosis, basal cell carcinoma, and skin warts. Fluorouracil is on the World Health Organization's List … of Essential Medicines, the most effective and safe medicines needed in a health system … . Fluorouracil exerts cytotoxic effects on the cell by direct incorporation into DNA and RNA as well as by inhibiting thymidylate synthase.

Matched Description: Escherichia coli can utilize the monosaccharide D-ribose as the sole source of carbon and energy … unphosphorylated beta-D-ribopyranose. Ribose pyranase converts between the furanose and pyranose forms of beta-D … -ribose. D-ribofuranose converts between the alpha and beta anomers quickly and spontaneously

Matched Description: Globoid Cell Leukodistrophy (GLD), also called Krabbe disease and galactosylceramide lipidosis, is … population and a worldwide incidence of 1/100,000-1/250,000 live births. GLD is an autosomal recessive … is a lysosomal protein that hydrolyzes the galactose ester bonds of ceramides and ceramide … derivatives including galactocerebroside, galactosylsphingosine (psychosine), lactosylceramide, and … catabolism (via the removal of galactose) of galactosylceramide, a major lipid in myelin, kidney, and

Matched Description: (cetirizine). H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are … , allergic conjunctivitis, and urticaria. Reducing the activity of the NF-κB immune response … transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways … also decreases antigen presentation and the expression of pro-inflammatory cytokines, cell adhesion … molecules, and chemotactic factors. Furthermore, lowering calcium ion concentration leads to increased

Matched Description: Atoltivimab (REGN 3470), Odesivimab (REGN 3471), and Maftivimab are monoclonal antibody (mAb) and … and GP2 glycoprotein of Zaire ebolavirus. INMAZEB, formally known as REGN-EB3, is a combination of … Atoltivimab, Odesivimab, and Maftivimab in equimolar proportions. Each of them bind to a distinct … portion of the GP1,2 glycoprotein and protect against ebola virus infection.It has not been established … produced by Regeneron Pharmaceuticals and was granted FDA approval on October 14, 2020. Ebola virus (Zaire

Matched Description: hydrogen bonding. This binding ends up causing crosslinks and strand breaks. Mitoxantrone can also … interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, the enzyme … responsible for uncoiling and repairing damaged DNA. This drug has a cytocidal effect on proliferating cells … and nonproliferation cells, this suggests that it is not a cell cycle-specific drug. Mitoxantrone is administered in an intravenous injection.