SMP0126846
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Sulfaphenazole Action Pathway
Mycobacterium leprae
Matched Description: for the treatment of many different bacterial infections like leprosy. It is used in humans and … enzyme does the condensation of p-aminobenzoic acid (PABA) and dihydropteroate diphosphate. This … reaction, and the ones following, results in the synthesis of folate. Folate is an important molecule … for the growth of the bacteria. The inhibition of their synthesis results in the inhibition of their growth and, in the long term, their death.
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SMP0125686
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Globoid Cell Leukodystrophy
Homo sapiens
Matched Description: Globoid Cell Leukodistrophy (GLD), also called Krabbe disease and galactosylceramide lipidosis, is … population and a worldwide incidence of 1/100,000-1/250,000 live births. GLD is an autosomal recessive … is a lysosomal protein that hydrolyzes the galactose ester bonds of ceramides and ceramide … derivatives including galactocerebroside, galactosylsphingosine (psychosine), lactosylceramide, and … catabolism (via the removal of galactose) of galactosylceramide, a major lipid in myelin, kidney, and
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SMP0126923
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Gadoteridol Metabolism
Homo sapiens
Matched Description: lesions with disrupted blood-brain barrier and/or abnormal vascularity in the brain, spine, and associated … tissues in adult and pediatric patients, including term neonates. It is also indicated for … visualization of lesions in the head and neck in adult patients. Gadoteridol provides contrast enhancement … of the brain, spine and surrounding tissues resulting in improved visualization (compared with … head, neck, liver, breast, musculoskeletal system and soft tissue pathologies. n MRI, visualization
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SMP0124667
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Flecainide Antiarrhythmic Action Pathway
Homo sapiens
Matched Description: including sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias … neuron back to resting potential. The action potentials created travel down the axon of the neuron and … causes synaptic vesicles containing neurotransmitters like glutamate to fuse with the membrane and expel … the neurotransmitter into the synapse. Glutamate binds to AMPA and NMDA receptor on the post … , flecainide prevents the depolarization phase, inhibiting action potential generation and the
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SMP0124562
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Streptomycin Action Pathway (New)
Homo sapiens
Matched Description: aminoglycosides family and it is derived from Streptomyces griseus which was the first effective … development of resistance and toxicity. Streptomycin goes through 3 phases in order to infiltrate the … bacterial cell and inhibit protein synthesis: the first phase is the binding of polycationic drug to the … travels and binds to the 16rRNA and 30S ribosomal subunit. The final phase is the inhibition of protein … synthesis and the accumulation of Streptomycin in the cell which further exacerbates its inhibition
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SMP0334098
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Ribose Degradation
Bacteroides stercoris ATCC 43183
Matched Description: Escherichia coli can utilize the monosaccharide D-ribose as the sole source of carbon and energy … unphosphorylated beta-D-ribopyranose. Ribose pyranase converts between the furanose and pyranose forms of beta-D … -ribose. D-ribofuranose converts between the alpha and beta anomers quickly and spontaneously
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SMP0352791
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Ribose Degradation
Escherichia coli E24377A
Matched Description: Escherichia coli can utilize the monosaccharide D-ribose as the sole source of carbon and energy … unphosphorylated beta-D-ribopyranose. Ribose pyranase converts between the furanose and pyranose forms of beta-D … -ribose. D-ribofuranose converts between the alpha and beta anomers quickly and spontaneously
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SMP0352796
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Ribose Degradation
Escherichia coli UMN026
Matched Description: Escherichia coli can utilize the monosaccharide D-ribose as the sole source of carbon and energy … unphosphorylated beta-D-ribopyranose. Ribose pyranase converts between the furanose and pyranose forms of beta-D … -ribose. D-ribofuranose converts between the alpha and beta anomers quickly and spontaneously
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SMP0352803
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Ribose Degradation
Escherichia coli IAI39
Matched Description: Escherichia coli can utilize the monosaccharide D-ribose as the sole source of carbon and energy … unphosphorylated beta-D-ribopyranose. Ribose pyranase converts between the furanose and pyranose forms of beta-D … -ribose. D-ribofuranose converts between the alpha and beta anomers quickly and spontaneously
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SMP0335059
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Ribose Degradation
Fusobacterium varium ATCC 27725
Matched Description: Escherichia coli can utilize the monosaccharide D-ribose as the sole source of carbon and energy … unphosphorylated beta-D-ribopyranose. Ribose pyranase converts between the furanose and pyranose forms of beta-D … -ribose. D-ribofuranose converts between the alpha and beta anomers quickly and spontaneously
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