SMP0378128
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Biosynthesis of Siderophore Group Nonribosomal Peptides
Bacteroides sp. D20
Matched Description: 2,3-Dihydroxybenzoate is created from chorismate through isochorismate and 2,3-dihydroxy-2,3 … dehydrogenase. This compound then interacts with L-serine and ATP through the enterobactin synthase protein … membrane transport complex. Ferric enterobactin continues it's journey and enters the cytoplasm via a … enterochelin esterase resulting in the release of 2,3-dihydroxybenzoylserine, Fe3+, and hydrogen ions.
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SMP0378143
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Biosynthesis of Siderophore Group Nonribosomal Peptides
Prevotella disiens FB035-09AN
Matched Description: 2,3-Dihydroxybenzoate is created from chorismate through isochorismate and 2,3-dihydroxy-2,3 … dehydrogenase. This compound then interacts with L-serine and ATP through the enterobactin synthase protein … membrane transport complex. Ferric enterobactin continues it's journey and enters the cytoplasm via a … enterochelin esterase resulting in the release of 2,3-dihydroxybenzoylserine, Fe3+, and hydrogen ions.
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SMP0378240
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Biosynthesis of Siderophore Group Nonribosomal Peptides
Haemophilus haemolyticus M19501
Matched Description: 2,3-Dihydroxybenzoate is created from chorismate through isochorismate and 2,3-dihydroxy-2,3 … dehydrogenase. This compound then interacts with L-serine and ATP through the enterobactin synthase protein … membrane transport complex. Ferric enterobactin continues it's journey and enters the cytoplasm via a … enterochelin esterase resulting in the release of 2,3-dihydroxybenzoylserine, Fe3+, and hydrogen ions.
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SMP0378252
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Biosynthesis of Siderophore Group Nonribosomal Peptides
Vibrio fluvialis PG41
Matched Description: 2,3-Dihydroxybenzoate is created from chorismate through isochorismate and 2,3-dihydroxy-2,3 … dehydrogenase. This compound then interacts with L-serine and ATP through the enterobactin synthase protein … membrane transport complex. Ferric enterobactin continues it's journey and enters the cytoplasm via a … enterochelin esterase resulting in the release of 2,3-dihydroxybenzoylserine, Fe3+, and hydrogen ions.
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SMP0012444
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Mannose Metabolism
Arabidopsis thaliana
Matched Description: Mannose is a sugar monomer of the aldohexose series of carbohydrates and is a C-2 epimer of glucose … . It is a key monosaccharide for protein and lipid glycosylation . The majority of mannose … isomerase catalyzes the interconversion of beta-D-fructose 6-phosphate and D-mannose 6-phosphate. It … the interconversion of D-mannose 6-phosphate and D-mannose 1-phosphate. However, D-mannose 1 … -phosphate can also be synthesized from ADP-mannose in the chloroplast via nudix hydrolase 14 and a magnesium
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SMP0002214
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Operon: Glycine Cleavage System
Escherichia coli
Matched Description: , a reduced pyridine nucleotide that cam be reused, and 5,10-methylenetetrahydrofolate. This operon … regulatory protein, (Lrp) which is activated by the binding of L-leucine. Both Lrp and CRP bind to the … . This protein transfers the methylamine group of glycine between the P and T-proteins of the cleavage … known as the glycine cleavage system P-protein. This protein binds to and cleaves the amino group of … glycine, transferring it to the complex with the H-protein and releasing carbon dioxide.
Gene Regulatory
Transport/Degradation
Cellular Response
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SMP0125274
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Naltrexone Opioid Antagonist Action Pathway
Homo sapiens
Matched Description: dependence in conjunction with behavioural programs. Naltrexone inhibits Mu, Kappa, and Delta opioid … on the neuron. This allows calcium to enter the neuron and depolarize. The inhibition of mu-opioid … is able to depolarize and the high concentration of calcium releases GABA into the synapse which … . This prevents the analgesic and depressive effects of opioids, preventing opioid overdose. GABA … opioids and other drugs. The major metabolite, 6-β-naltrexol is also a opioid antagonist that may contribute to the effects of naltrexone.
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SMP0002297
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Proline Metabolism
Saccharomyces cerevisiae
Matched Description: , a NADP and a L-glutamic gamma-semialdehyde. L-glutamic gamma-semialdehyde is dehydrated … spontaneously, resulting in a release of water,hydrogen ion and 1-Pyrroline-5-carboxylic acid. The latter … to L-proline. L-proline works as a repressor of the pyrroline-5-carboxylate reductase enzyme and … genetic loci namely proB, proA and proC. The first reaction in the pathway is catalyzed by γ-glutamyl … protect the highly labile glutamyl phosphate from the hostile nucleophilic and aqueous environment
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SMP0126339
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Alvimopan Opioid Antagonist Action Pathway
Homo sapiens
Matched Description: upper and lower GI tract following surgical procedures. It is a μ-opioid antagonist action only on the … peripheral receptors and not on the one in the central nervous system. Alvimopan competitively … neuron and depolarize. The inhibition of mu-opioid receptors prevents hyperpolarization in the … neuron, allowing it to fire at a normal rate. The neuron is able to depolarize and the high concentration … of calcium releases acetylcholine and nitric acid into the neuromuscular junction. Acetylcholine
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SMP0401655
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Galactose Metabolism
Acinetobacter radioresistens NIPH 2130
Matched Description: galactosidase and lactose degradation involving a beta galactosidase. Melibiose is first transported inside … through alpha galactosidase into an alpha-D-galactose and a beta-D-glucose. The beta-D-glucose is … degradation involving a lactose permease to uptake lactose from the environment and a beta-galactosidase to … interacts with water through a beta-galactosidase resulting in a beta-D-glucose and beta-D-galactose … 1-phosphate) interacts with UTP and a hydrogen ion in order to produce a uridine diphosphate
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