SMP0002597
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Phosphatidylcholine Biosynthesis PC(14:1(11Z)/18:1(11Z))
Saccharomyces cerevisiae
Matched Description: -methyltransferase resulting in the release of hydrogen ion and S-adenosylhomocysteine an a PE-NMe. The … -methyltransferase resulting in the release of hydrogen ion, s-adenosylhomocysteine and PE-NMe2. The PE-NMe2 reacts … resuilting in the release of hydrogen ion, s-adenosylhomocysteine and PC
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SMP0002580
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Phosphatidylcholine Biosynthesis PC(14:1(11Z)/16:1(11Z))
Saccharomyces cerevisiae
Matched Description: -methyltransferase resulting in the release of hydrogen ion and S-adenosylhomocysteine an a PE-NMe. The … -methyltransferase resulting in the release of hydrogen ion, s-adenosylhomocysteine and PE-NMe2. The PE-NMe2 reacts … resuilting in the release of hydrogen ion, s-adenosylhomocysteine and PC
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SMP0002554
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Phosphatidylcholine Biosynthesis PC(10:0/16:1(11Z))
Saccharomyces cerevisiae
Matched Description: -methyltransferase resulting in the release of hydrogen ion and S-adenosylhomocysteine an a PE-NMe. The … -methyltransferase resulting in the release of hydrogen ion, s-adenosylhomocysteine and PE-NMe2. The PE-NMe2 reacts … resuilting in the release of hydrogen ion, s-adenosylhomocysteine and PC
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SMP0125944
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Elbasvir Action Pathway
Homo sapiens
Matched Description: -mediated endocytosis. The lipoviroparticles attach to LDL-R and SR-B1, and then the virus binds to … CD81 and subsequently claudin-1 and occludin, which mediate the late steps of viral entry. The virus is … and translated at the rough endoplasmic reticulum into a single Genome polyprotein. The genome … polyprotein is cleaved by host and viral proteases into 10 viral proteins. The nucleocapsid protein core … and the two envelope proteins E1 and E2 form the N terminus of the polyprotein and are the
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SMP0122688
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Hydrochlorothiazide Diuretic Action Pathway
Homo sapiens
Matched Description: , severe resistant edema, nephrogenic diabetes insipidus, and to prevent kidney stone formation in … , potassium, calcium, chloride, and magnesium occurs. In epithelial cells of the DCT, the … basolateral membrane consists of the Na+/K+ ATPase, which pumps Na+ into the interstitium-blood area and K … + into the epithelial cell; the Na+/Ca2+ exchanger, which pumps Na+ into the cell and Ca2+ into the … interstitium-blood; and the chloride transporter which transports chloride into the interstitium-blood
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SMP0125844
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Tavaborole Action Pathway
Homo sapiens
Matched Description: Tavaborole is an antifungal agent used to treat onychomycosis, a fungal infection of the nail and … synthesis and for the catalysis of ATP-dependent ligation of L-leucine to tRNA(Leu). This blocks the … protein synthesis in the fungal cell which leads to cell degradation and death.
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SMP0126183
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Atenolol Action Pathway (New)
Homo sapiens
Matched Description: through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. In … bronchial and vascular smooth muscle, atenolol can compete with epinephrine for beta-1 adrenergic … , which in turn activates PKA production, which then activates SRC and nitric oxide synthase, its … inhibition causes the inhibition of cAMP, PKA, SRC and nitric oxide synthase signaling. Following this … , the inhibition of SRC in essence causes the activation of Caspase 3 and Caspase 9. This Caspase
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SMP0126185
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Betaxolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: passes through hepatic portal circulation, and enters the bloodstream and travels to act on … cardiomyocytes. In bronchial and vascular smooth muscle, betaxolol can compete with epinephrine for beta … cAMP synthesis, which in turn activates PKA production, which then activates SRC and nitric oxide … synthase, its inhibition causes the inhibition of cAMP, PKA, SRC and nitric oxide synthase signaling … reaction chain, the inhibition of SRC in essence causes the activation of Caspase 3 and Caspase 9. This
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SMP0126930
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Norfloxacin Action Pathway
Haemophilus influenzae
Matched Description: -positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in … the urine.
Norfloxacin inhibits DNA gyrase (topoisomerase II) and topoisomerase IV. These proteins … prevent supercoiling in bacterial DNA. The inhibition of DNA gyrase (topoisomerase II) and
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SMP0124537
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Torasemide Action Pathway (New)
Homo sapiens
Matched Description: Torasemide is a loop diuretic drug, administered orally or intravenously to treat hypertension and … loop of henle contains the Na+/K+ ATPase, Cl- channel and K+/Cl- co-transporter which are essential … for the function for ion and water reabsorption. The Na+/K+ ATPase pumps Na+ from the cell into the … peritubular fluid and K+ from the peritubular fluid into the cell. The K+/Cl- co-transporter moves K … + and Cl- from the cell into the peritubular fluid and the Cl- channel transports Cl- from the cell
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