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Matched Description: schizophrenia and other psychotic disorders. Fluphenazine has not been shown effective in the management of … dopaminergic D1 and D2 receptors in the mesolimbic, nigrostriatal, and tuberoinfundibular neural … pathways in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to … , wakefulness, vasomotor tone, and emesis. Fluphenazine acts primarily through antagonism of postsynaptic … dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. The blockage of

Matched Description: Benzquinamide is a discontinued antiemetic compound with antihistaminic, mild anticholinergic, and … antagonism of muscarinic acetycholine receptors and histamine H1 receptors. H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and … vessels to constrict dilated blood vessels, and in smooth muscles of lungs and intestines to relax

Matched Description: hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. In … bronchial and vascular smooth muscle, nadolol can compete with epinephrine for beta-2 adrenergic receptors … beta 3 adrenal receptors. Antagonism of beta-1 and beta-2 adrenoceptors in the heart inhibits cyclic … AMP and its signalling pathway, decreasing the strength and speed of contractions as well as the … speed of relaxation and conduction. Antagonism of beta-2 adrenoceptors in the smooth muscle cells of

Matched Description: parasite’s food vacuole and inhibits the enzyme heme ligase. Heme ligase is involved in hemoglobin … . Hemoglobin is first broken down into heme and globin. Globin is further broken down to amino acids which … are used by the parasite for nutrition and protein synthesis. Therefore, hemoglobin breakdown is … essential for the parasite survival. The heme from hemoglobin is toxic to the parasite and is further … a bitter taste, and oral compliance is often poor. It is irritant to the gastric mucosa and can

Matched Description: Telavancin is an antibacterial agent used in the treatment of complicated skin and skin structure … infections and types of hospital-acquired bacterial pneumonia. Telavancin is a semi-synthetic … aureus (MRSA) and other gram-positive bacteria. It is used for the treatment of complicated skin and … -resistant Staphylococcus aureus, vancomycin-susceptible Enterococcus faecalis, and Streptococcus … of adult patients with hospital-acquired bacterial pneumonia (HAP) and ventilator-associated

Matched Description: Buprenorphine, trade name subutex, suboxone, zubsolv and bunavail, is a partial agonist of mu … -opioid receptors and a kappa-opioid receptor antagonist and is prescribed for opioid addiction to prevent … cravings and symptoms of withdrawal. The binding of these receptors causes hyperpolarization and … dissociation from the receptor. This long rate of action causes a long clinical effect and decreases … . This elimination of the rush from the opioid can block the reinforcing behaviour of the drug and may

Matched Description: -sensitive Gi proteins. It is involved in organogenesis, hematopoiesis, and the immune response … . Chemokine stromal cell-derived factor 1 (SDF-1) binds CXCR4. CXCR4 is also a co-receptor for HIV and is … adenylyl cyclase and activates tyrosine kinases, while activated guanine nucleotide binding protein beta … and gamma activate PI3K - regulating gene transcription, cell migration, and cell adhesion. PLC is … activated to cause the cleavage of PIP2 to IP3 and DG. This leads to the increase of calcium from the

Matched Description: -sensitive Gi proteins. It is involved in organogenesis, hematopoiesis, and the immune response … . Chemokine stromal cell-derived factor 1 (SDF-1) binds CXCR4. CXCR4 is also a co-receptor for HIV and is … adenylyl cyclase and activates tyrosine kinases, while activated guanine nucleotide binding protein beta … and gamma activate PI3K - regulating gene transcription, cell migration, and cell adhesion. PLC is … activated to cause the cleavage of PIP2 to IP3 and DG. This leads to the increase of calcium from the

Matched Description: , free radicals, and UV irradiation. It can also respond to bacterial and viral antigens; therefore … and immune diseases (and more) can be related to the incorrect regulation of the NF-κB complex. The … ), and the noncanonical (or alternative) pathway, which selectively responds to a specific group of … stimuli, such as groups of ligands of a subset of TNFR superfamily members (e.g. LTβR, BAFFR, CD40 and … RANK). Both pathways are important for regulating immune and inflammatory responses despite their differences in signalling mechanism.

Matched Description: pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor … agonist which acts in the brain, spinal cord, and peripherally. This means it reduces sympathetic … nervous system tone, and causes respiratory depression and analgesia. Remifentanil binds to mu opioid … adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease … neurotransmitters such as GABA is inhibited. Opioids close N-type voltage-operated calcium channels and open