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Matched Description: -sensitive Gi proteins. It is involved in organogenesis, hematopoiesis, and the immune response … . Chemokine stromal cell-derived factor 1 (SDF-1) binds CXCR4. CXCR4 is also a co-receptor for HIV and is … adenylyl cyclase and activates tyrosine kinases, while activated guanine nucleotide binding protein beta … and gamma activate PI3K - regulating gene transcription, cell migration, and cell adhesion. PLC is … activated to cause the cleavage of PIP2 to IP3 and DG. This leads to the increase of calcium from the

Matched Description: key step in proper circadian rhythm. Heterodimerization of clock proteins PER and CRY is required for … (CK1). Once in the nucleus, PER and CRY proteins appear to differentially inhibit the transactivation … by CLOCK/BMAL1. Proteins like REV-ERBa and DEC also regulate the transcriptional activation by CLOCK … /BMAL1. In addition, CRY, PER, and BMAL1-CLOCK play bidirectional roles in transcription resulting in … interactivating feedback loops. The expression of BMAL1 and CLOCK can be upregulated by CRY and PER

Matched Description: episodes of psychotic disorders. It can also be used to control severe nausea and vomiting, severe … hiccups, and moderate to severe pain in some hospitalized patients. Triflupromazine acts on the central … dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone (CTZ) and vomiting centre … . Triflupromazine blocks the neurotransmitter dopamine and the vagus nerve in the gastrointestinal tract … . Triflupromazine also binds the muscarinic acetylcholine receptors (M1 and M2) and the tryptamine D

Matched Description: Pazopanib is an antineoplastic agent utilized for treating advanced renal cell cancer and advanced … growth factor receptors (PDGFR-alpha, PDGFR-beta), and c-kit, which are integral to the angiogenesis … pathway, pazopanib hinders tumor blood vessel formation, ultimately impeding tumor survival and … phosphorylation and exhibits anti-tumor effects, leading to a reduction in tumor blood flow, increased … tumor apoptosis, inhibited growth, and hypoxia in cancer cells. Although absorption is slow and

Matched Description: pancreas and regulates blood glucose levels. Medical treatment with insulin is indicated when there is … regulation of glucose levels in the body. It stimulates the storage of energy and inhibits the breakdown … of cells, with the maximum density being on the hepatic cells and adipocytes. The insulin receptor is … a heterotetrameric glycoprotein consisting of two subunits, the alpha and the beta subunits. The … synthesis, DNA synthesis, and cellular growth and differentiation. Once glucose gets absorbed from a

Matched Description: was first authorized for use in the US in November 2001 and in Europe in April 2002. Shown to be … effective against a wide range of Gram-positive and Gram-negative aerobic and anaerobic bacteria … . It works by binding to and inhibiting bacterial penicillin-binding proteins (PBPs).5 In Escherichia … coli, it has a strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preferential binding to PBPs … 2 and 3.5 Upon binding to PBPs, ertapenem inhibits bacterial cell wall synthesis by interfering with

Matched Description: was first authorized for use in the US in November 2001 and in Europe in April 2002. Shown to be … effective against a wide range of Gram-positive and Gram-negative aerobic and anaerobic bacteria … action. It works by binding to and inhibiting bacterial penicillin-binding proteins (PBPs).5 In … Escherichia coli, it has a strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preferential binding to … PBPs 2 and 3.5 Upon binding to PBPs, ertapenem inhibits bacterial cell wall synthesis by interfering

Matched Description: Aceprometazine is a is a drug with neuroleptic and anti-histamine properties. Although not widely … sedation by being able to cross the blood-brain-barrier and binding to H1-receptors in the central … nervous system. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and … rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 receptors in T-cells to … inhibit the immune response, in blood vessels to constrict dilated blood vessels, and in smooth

Matched Description: Alfentanil is used to induce and maintain anesthesia, as well as an analgesic. Alfentanil is a … short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak … analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during … surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically … cord, and other tissues. In clinical settings, alfentanil exerts its principal pharmacologic effects

Matched Description: Ritodrine is a adrenergic beta agonist used for the treatment and prophylaxis of premature labour … , increases cAMP level and decreases intracellular calcium concentration. The decrease of calcium … concentration leads to a relaxation of uterine smooth muscle and, therefore, a decrease in premature uterine … administered and it binds to the beta-2 adrenergic receptor, the G protein signalling cascade begins … . The alpha and beta/gamma subunits of the G protein separate and GDP is replaced with GTP on the