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Matched Description: channels and typically used to treat ventricular arrhythmias. It is used to treat conditions including … sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias. Tocainide is … ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and … man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and … anticholinergic and local anesthetic properties. Side effects of tocainide include nausea, vomiting, headaches, feeling dizzy, or feeling hot and flushed.

Matched Description: ABC or SLC transporters like ABCB1 and works by forming a complex with FKBP12 with inhibits … calcineurin with leads to reduced T cell signal transduction and IL-2 transcription. IL-2 is an important … mediator for T-cell activation, differentiation and migration which is through mTOR signalling. Lower … IL-2 production and signal transduction leads to less activated immune cells leading to a weaker … immune system. Cyclosporin A also inhibits the transcription for genes encoding IL-3,4,5, GM-SCF, and

Matched Description: molecules. It is produced by some plants, bacteria, fungi and invertebrates, and can be used as a … source of energy, such as for flight in insects, and as a survival mechanism to avoid freezing and … stream, and is transported to liver hepatocytes. Once in the liver, glucokinase can use the energy and

Matched Description: platelets. Ticlopidine is taken orally and is a prodrug that must be metabolically activated before it can … be effective. It first enters the liver and enters the endoplasmic reticulum where it is metabolized … to form the active metabolite. First, it is catalyzed by cytochromes P450 2C19, 2B6 and 1A2 into 2 … -oxoclopidogrel. Secondly, it is processed by cytochromes P450 2B6, 2C9, 2C19, 3A4, 3A5, and serum … surface of platelet cells, preventing ADP from binding to and activating it. Clopidogrel prevents the

Matched Description: in combination with hydrochlorothiazide, and to treat hypertensive crises. Methyldopa is … -dihydroxyphenylacetone; α-methyldopamine; and 3-O-methyl-α-methyldopamine. These metabolites are further … prominent metabolites are alpha-methyldopamine and the glucuronide of dihydroxyphenylacetone, along with … as unchanged parent drug (24%) and α-methyldopa mono-O-sulfate (64%), with variability.3-O-methyl-α … -dihydroxyphenylacetone, α-methyldopamine, and 3-O-methyl-α-methyldopamine and their conjugates are also excreted in urine.

Matched Description: Drotaverine is a phosphodiesterase-4 inhibitor used to alleviate gastrointestinal and … activating M3 muscarinic receptors. M3 muscarinic receptors are coupled to Gq protein, and thus … -triphosphate (IP3) and diacylglycerol. IP3 stimulates IP3 receptors on the endoplasmic reticulum(ER … kinase, thereby inactivating it and preventing it’s phosphorylation of myosin light chain. This leads … to an accumulation of unphosphorylated myosin light chain and ultimately, muscle relaxation

Matched Description: like ABCB1 and works by forming a complex with FKBP12 with inhibits calcineurin with leads to … reduced T cell signal transduction and IL-2 transcription. IL-2 is an important mediator for T-cell … activation, differentiation and migration which is through mTOR signalling. Lower IL-2 production and … also inhibits the transcription for genes encoding IL-3,4,5, GM-SCF, and TNF as well which are also … transplant for liver, kidney, heart, small bowel, pancreas, lung, trachea, skin, cornea and limb transplant.

Matched Description: fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, and bone infections … bacterial membranes causing displacement of divalent cations and increasing membrane permeability … bacterial 30S ribosome and binds to it, halting protein synthesis. It binds to the site where the … normal base pairing of codon and anti-codon takes place as well as adding amino acids to the growing … polypeptide chain, with this blocked it leads to termination of the chain and production of non

Matched Description: Iodipamide is a contrast agent used in cholangiography and cholecystography. Organic iodine … (concentration and volume) of the iodinated contrast agent in the path of the x-rays. Iodipamide's primary … excretion through the hepato-biliary system and concentration in bile allows visualization of the … gallbladder and biliary ducts. iodipamide is carried to the liver where it is rapidly secreted. The … of the hepatic and common bile ducts, even in cholecystectomized patients. The biliary ducts are

Matched Description: species and Aspergillus species in severely immunocompromised patients. For prophylaxis of invasive … Aspergillus and Candida infections in patients, 13 years of age and older, who are at high risk of … of the triazolone side chain. These modifications enhance the potency and spectrum of activity of … cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells … . This leads to cell lysis which causes it to collapse and die.