SMP0126395
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Trihexyphenidyl Action Pathway
Homo sapiens
Matched Description: and as a treatment for extrapyramidal symptoms caused by drugs affecting the central nervous system … higher affinity for central muscarinic receptors located in the cerebral cortex and lower affinity for … innervated by the parasympathetic system, such as the salivary glands, eyes, and smooth muscles … (directly and indirectly), are affected, even at smaller doses. Possible side effects of using … Trihexyphenidyl may include dry mouth, constipation, nausea, and vomiting. Trihexyphenidyl is administered as an oral tablet.
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SMP0124551
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Vindesine Action Pathway (New)
Homo sapiens
Matched Description: treatment of acute leukemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute … microtubules induces two proteins; cellular tumor antigen p53 and cyclin-dependent kinase inhibitor … former protein, p53, acts on BAK and BAX to enact conformational changes, creating pores in the … cell, which cleave essential cellular proteins. In this way, p53 and p21 work alongside each other … to promote apoptosis and terminate unhealthy cells. Vindesine is especially valuable as a drug
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SMP0121069
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Fatty Acid Elongation
Drosophila melanogaster
Matched Description: starts with acetyl-CoA and butyryl-CoA, a coenzyme A activated form of butyric acid, a 4-carbon fatty … , tetradecanoyl-CoA and finally the 16 carbon hexadecanoyl-CoA.
Finally, hexadecanoyl is transported out of … the mitochondrion and into the lysosome, where palmitoyl-protein thioesterase 1 catalyzes its … reversible reaction with a water molecule that removes the CoA group and forms palmitic acid. Palmitic acid … is the final product of this pathway, and it is involved in the fatty acid degradation pathway.
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SMP0126275
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Propafenone Action Pathway
Homo sapiens
Matched Description: fibrillation/flutter and ventricular arrhythmias. It can be found under the brand name Rhythmol. Used to … monophasic action potential. In Purkinje fibers, and to a lesser extent myocardial fibers … antiarrhythmic actions. Diastolic excitability threshold is increased and effective refractory period … prolonged. Propafenone reduces spontaneous automaticity and depresses triggered activity. At very high … administered as an oral tablet. Some side effects of using propafenone may include dizziness, dry mouth, headache, and nausea.
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SMP0412771
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Mannose Metabolism
Escherichia coli IAI39
Matched Description: Escherichia coli can utilize D-mannose for its sole carbon and energy source. Alpha-D-mannose is … isomerase. D-fructose-6-phosphate is an intermediate of glycolysis and can enter the pathways of … phosphorylated aldohexoses (β-D-glucose-6-phosphate, D-mannose-6-phosphate) and phosphorylated ketohexoses (D … phosphomannomutase and mannose-1-phosphate guanylyltransferase. GDP-D-mannose produces GDP-L-fucose beginning … epimerase and reductase of GDP-4-dehydro-6-deoxy-D-mannose. L-fucose then enters the colanic acid building blocks biosynthesis pathway.
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SMP0413497
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Mannose Metabolism
Escherichia coli IHE3034
Matched Description: Escherichia coli can utilize D-mannose for its sole carbon and energy source. Alpha-D-mannose is … isomerase. D-fructose-6-phosphate is an intermediate of glycolysis and can enter the pathways of … phosphorylated aldohexoses (β-D-glucose-6-phosphate, D-mannose-6-phosphate) and phosphorylated ketohexoses (D … phosphomannomutase and mannose-1-phosphate guanylyltransferase. GDP-D-mannose produces GDP-L-fucose beginning … epimerase and reductase of GDP-4-dehydro-6-deoxy-D-mannose. L-fucose then enters the colanic acid building blocks biosynthesis pathway.
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SMP0412492
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Mannose Metabolism
Escherichia coli 536
Matched Description: Escherichia coli can utilize D-mannose for its sole carbon and energy source. Alpha-D-mannose is … isomerase. D-fructose-6-phosphate is an intermediate of glycolysis and can enter the pathways of … phosphorylated aldohexoses (β-D-glucose-6-phosphate, D-mannose-6-phosphate) and phosphorylated ketohexoses (D … phosphomannomutase and mannose-1-phosphate guanylyltransferase. GDP-D-mannose produces GDP-L-fucose beginning … epimerase and reductase of GDP-4-dehydro-6-deoxy-D-mannose. L-fucose then enters the colanic acid building blocks biosynthesis pathway.
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SMP0412550
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Mannose Metabolism
Escherichia coli HS
Matched Description: Escherichia coli can utilize D-mannose for its sole carbon and energy source. Alpha-D-mannose is … isomerase. D-fructose-6-phosphate is an intermediate of glycolysis and can enter the pathways of … phosphorylated aldohexoses (β-D-glucose-6-phosphate, D-mannose-6-phosphate) and phosphorylated ketohexoses (D … phosphomannomutase and mannose-1-phosphate guanylyltransferase. GDP-D-mannose produces GDP-L-fucose beginning … epimerase and reductase of GDP-4-dehydro-6-deoxy-D-mannose. L-fucose then enters the colanic acid building blocks biosynthesis pathway.
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SMP0401742
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Mannose Metabolism
Alistipes shahii WAL 8301
Matched Description: Escherichia coli can utilize D-mannose for its sole carbon and energy source. Alpha-D-mannose is … isomerase. D-fructose-6-phosphate is an intermediate of glycolysis and can enter the pathways of … phosphorylated aldohexoses (β-D-glucose-6-phosphate, D-mannose-6-phosphate) and phosphorylated ketohexoses (D … phosphomannomutase and mannose-1-phosphate guanylyltransferase. GDP-D-mannose produces GDP-L-fucose beginning … epimerase and reductase of GDP-4-dehydro-6-deoxy-D-mannose. L-fucose then enters the colanic acid building blocks biosynthesis pathway.
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SMP0412867
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Mannose Metabolism
Escherichia coli O111:H- str. 11128
Matched Description: Escherichia coli can utilize D-mannose for its sole carbon and energy source. Alpha-D-mannose is … isomerase. D-fructose-6-phosphate is an intermediate of glycolysis and can enter the pathways of … phosphorylated aldohexoses (β-D-glucose-6-phosphate, D-mannose-6-phosphate) and phosphorylated ketohexoses (D … phosphomannomutase and mannose-1-phosphate guanylyltransferase. GDP-D-mannose produces GDP-L-fucose beginning … epimerase and reductase of GDP-4-dehydro-6-deoxy-D-mannose. L-fucose then enters the colanic acid building blocks biosynthesis pathway.
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