SMP0100124
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Phosphatidylcholine/Phosphatidylethanolamine Biosynthesis PC(14:0/16:0) | PE(14:0/16:0)
Caenorhabditis elegans
Matched Description: and has both structural and signalling roles. In eukaryotes, there exist two phosphatidylcholine … biosynthesis pathways: the Kennedy pathway and the methylation pathway. The Kennedy pathway begins … -choline and subsequently phosphatidylcholine. It is the major synthesis route in animals. In the … most abundant phospholipid in eukaryotic cell membranes, and contrary to phosphatidylcholine, they are
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SMP0100211
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Phosphatidylcholine/Phosphatidylethanolamine Biosynthesis PC(18:1(9Z)/18:2(9Z,12Z)) | PE(18:1(9Z)/18:2(9Z,12Z))
Caenorhabditis elegans
Matched Description: and has both structural and signalling roles. In eukaryotes, there exist two phosphatidylcholine … biosynthesis pathways: the Kennedy pathway and the methylation pathway. The Kennedy pathway begins … -choline and subsequently phosphatidylcholine. It is the major synthesis route in animals. In the … most abundant phospholipid in eukaryotic cell membranes, and contrary to phosphatidylcholine, they are
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SMP0100213
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Phosphatidylcholine/Phosphatidylethanolamine Biosynthesis PC(18:1(9Z)/18:3(9Z,12Z,15Z)) | PE(18:1(9Z)/18:3(9Z,12Z,15Z))
Caenorhabditis elegans
Matched Description: and has both structural and signalling roles. In eukaryotes, there exist two phosphatidylcholine … biosynthesis pathways: the Kennedy pathway and the methylation pathway. The Kennedy pathway begins … -choline and subsequently phosphatidylcholine. It is the major synthesis route in animals. In the … most abundant phospholipid in eukaryotic cell membranes, and contrary to phosphatidylcholine, they are
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SMP0100230
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Phosphatidylcholine/Phosphatidylethanolamine Biosynthesis PC(18:2(9Z,12Z)/18:2(9Z,12Z)) | PE(18:2(9Z,12Z)/18:2(9Z,12Z))
Caenorhabditis elegans
Matched Description: and has both structural and signalling roles. In eukaryotes, there exist two phosphatidylcholine … biosynthesis pathways: the Kennedy pathway and the methylation pathway. The Kennedy pathway begins … -choline and subsequently phosphatidylcholine. It is the major synthesis route in animals. In the … most abundant phospholipid in eukaryotic cell membranes, and contrary to phosphatidylcholine, they are
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SMP0123260
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Roxithromycin Anti=Bacterial Action Pathway
Homo sapiens
Matched Description: history of type I penicillin hypersensitivity, pharyngitis and tonsillitis caused by susceptible … ' disease, and pertussis, skin or skin structure infections, helicobacter pylori infection, duodenal ulcer … disease, bartonella infections, early Lyme disease, and encephalitis caused by Toxoplasma gondii (in … cell wall of usually gram negative bacteria and act synergistically to inhibit protein synthesis … , preventing bacterial growth and this may even kill the bacteria. Roxithromycin was shown to be more
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SMP0126430
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Levomilnacipran SNRI - Norepinephrine reuptake Inhibition Action Pathway
Homo sapiens
Matched Description: Levomilnacipran (the more active 1S, 2R - enantiomer of milnacipran) is a serotonin and … , generalized anxiety disorder, chronic musculoskeletal pain and diabetic peripheral neuropathy. It is … generally believed that 5HT and NE participate in the modulation of endogenous analgesic mechanisms by way … of the descending inhibitory pain pathways in the brain and spinal cord. Although the specific … -relay neurons, and by alpha-1-adrenoceptor-mediated activation of inhibitory interneurons. Such NE pain
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SMP0126265
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Procainamide Action Pathway (New)
Homo sapiens
Matched Description: ventricular dysrhythmias, tachycardia and atrial fibrillation. Procainamide mainly inhibits sodium channels … slows the rate of rise in the pacemaker potential and shortens the plateau phase of atrial and … channel and block it. Procainamide can be administered through either oral or intravenous routes with both … may include cardiac toxicity, bradycardia, hypotension, drug-induced lupus erythematosus-like syndrome, and blood dyscrasias.
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SMP0126272
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Eslicarbazepine Acetate Action Pathway
Homo sapiens
Matched Description: found under the brand names Aptiom and Zebinix. Eslicarbazepine acetate (ESL) is an anticonvulsant … medication approved for use in Europe, the United States and Canada as an adjunctive therapy for … exert anticonvulsant activity by inhibiting repeated neuronal firing and stabilizing the inactivated … inactivated state of voltage-gated sodium channels and preventing their return to the activated state … has a role in anticonvulsant activity. Some side effects of using eslicarbazepine acetate may include dizziness, nausea, headache, and aphasia.
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SMP0125026
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Levorphanol Opioid Agonist Action Pathway
Homo sapiens
Matched Description: doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood … GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the … close N-type voltage-operated calcium channels and open calcium-dependent inwardly rectifying potassium … channels. This results in hyperpolarization and reduced neuronal excitability. Levorphanol acts at … A delta and C pain fibres in the dorsal horn of the spinal cord. By decreasing neurotransmitter
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SMP0127006
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Sibutramine Dopamine Reuptake Inhibitor Action Pathway
Homo sapiens
Matched Description: Sibutramine, commonly known as Meridia or Reductil, is a norepinephrine, serotonin and dopamine … reuptake inhibitor used for the treatment of obesity. This drug was withdrawn from US and Canadian … markets for increased risk of heart attack and stroke in patients with heart disease history … . Sibutramine stimulates the nervous system through the reuptake of norepinephrine, serotonin and dopamine … neuron is stimulated and fires. Sibutramine binds to the sodium-dependent dopamine transporter
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