SMP0401424
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Galactose Metabolism
Escherichia coli (strain K12)
Matched Description: galactosidase and lactose degradation involving a beta galactosidase. Melibiose is first transported inside … through alpha galactosidase into an alpha-D-galactose and a beta-D-glucose. The beta-D-glucose is … degradation involving a lactose permease to uptake lactose from the environment and a beta-galactosidase to … interacts with water through a beta-galactosidase resulting in a beta-D-glucose and beta-D-galactose … 1-phosphate) interacts with UTP and a hydrogen ion in order to produce a uridine diphosphate
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SMP0410534
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Galactose Metabolism
Escherichia coli str. K-12 substr. MG1655
Matched Description: galactosidase and lactose degradation involving a beta galactosidase. Melibiose is first transported inside … through alpha galactosidase into an alpha-D-galactose and a beta-D-glucose. The beta-D-glucose is … degradation involving a lactose permease to uptake lactose from the environment and a beta-galactosidase to … interacts with water through a beta-galactosidase resulting in a beta-D-glucose and beta-D-galactose … 1-phosphate) interacts with UTP and a hydrogen ion in order to produce a uridine diphosphate
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SMP0401466
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Galactose Metabolism
Escherichia coli (strain K12 / MC4100 / BW2952)
Matched Description: galactosidase and lactose degradation involving a beta galactosidase. Melibiose is first transported inside … through alpha galactosidase into an alpha-D-galactose and a beta-D-glucose. The beta-D-glucose is … degradation involving a lactose permease to uptake lactose from the environment and a beta-galactosidase to … interacts with water through a beta-galactosidase resulting in a beta-D-glucose and beta-D-galactose … 1-phosphate) interacts with UTP and a hydrogen ion in order to produce a uridine diphosphate
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SMP0012444
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Mannose Metabolism
Arabidopsis thaliana
Matched Description: Mannose is a sugar monomer of the aldohexose series of carbohydrates and is a C-2 epimer of glucose … . It is a key monosaccharide for protein and lipid glycosylation . The majority of mannose … isomerase catalyzes the interconversion of beta-D-fructose 6-phosphate and D-mannose 6-phosphate. It … the interconversion of D-mannose 6-phosphate and D-mannose 1-phosphate. However, D-mannose 1 … -phosphate can also be synthesized from ADP-mannose in the chloroplast via nudix hydrolase 14 and a magnesium
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SMP0002214
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Operon: Glycine Cleavage System
Escherichia coli
Matched Description: , a reduced pyridine nucleotide that cam be reused, and 5,10-methylenetetrahydrofolate. This operon … regulatory protein, (Lrp) which is activated by the binding of L-leucine. Both Lrp and CRP bind to the … . This protein transfers the methylamine group of glycine between the P and T-proteins of the cleavage … known as the glycine cleavage system P-protein. This protein binds to and cleaves the amino group of … glycine, transferring it to the complex with the H-protein and releasing carbon dioxide.
Gene Regulatory
Transport/Degradation
Cellular Response
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SMP0125274
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Naltrexone Opioid Antagonist Action Pathway
Homo sapiens
Matched Description: dependence in conjunction with behavioural programs. Naltrexone inhibits Mu, Kappa, and Delta opioid … on the neuron. This allows calcium to enter the neuron and depolarize. The inhibition of mu-opioid … is able to depolarize and the high concentration of calcium releases GABA into the synapse which … . This prevents the analgesic and depressive effects of opioids, preventing opioid overdose. GABA … opioids and other drugs. The major metabolite, 6-β-naltrexol is also a opioid antagonist that may contribute to the effects of naltrexone.
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SMP0127035
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Neuronal Dopamine Gi Cascade
Mus musculus
Matched Description: subtypes, D1 through D5. D1 and D5 couple to Gs/olf and activate adenylyl cyclase, whereas D2, D3, and … D4 couple to Gi/o and inhibit it. Most GPCRs upon activation by an agonist are phosphorylated by … with GPCR only after stimulation with a ligand. G proteins have three subunits (α,β, and γ). When … a GPCR is activated, it induces the α subunit to release GDP and instead binds to guanosine … . The α subunit of G protein has a GTPase activity, and once it hydrolyzes GTP to GDP, it becomes
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SMP0127036
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Neuronal Dopamine Gi Cascade
Bos taurus
Matched Description: subtypes, D1 through D5. D1 and D5 couple to Gs/olf and activate adenylyl cyclase, whereas D2, D3, and … D4 couple to Gi/o and inhibit it. Most GPCRs upon activation by an agonist are phosphorylated by … with GPCR only after stimulation with a ligand. G proteins have three subunits (α,β, and γ). When … a GPCR is activated, it induces the α subunit to release GDP and instead binds to guanosine … . The α subunit of G protein has a GTPase activity, and once it hydrolyzes GTP to GDP, it becomes
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SMP0127031
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Neuronal Dopamine Gs Cascade
Rattus norvegicus
Matched Description: subtypes, D1 through D5. D1 and D5 couple to Gs/olf and activate adenylyl cyclase, whereas D2, D3, and … D4 couple to Gi/o and inhibit it. Most GPCRs upon activation by an agonist are phosphorylated by … with GPCR only after stimulation with a ligand. G proteins have three subunits (α,β, and γ). When … a GPCR is activated, it induces the α subunit to release GDP and instead binds to guanosine … . The α subunit of G protein has a GTPase activity, and once it hydrolyzes GTP to GDP, it becomes
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SMP0126674
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Bromocriptine Mechanism of Action Action Pathway
Homo sapiens
Matched Description: receptors, stimulating locomotion and attenuating the bradykinetic symptoms caused by the … anterior pituitary lactotrophic cells blocks prolactin exocytosis and gene expression, reducing the … and blocks IP3-dependent release of Ca2+ from intracellular stores. Decreases in intracellular … phosphorylation of p42/p44 MAPK and decreases MAPK/ERK kinase phosphorylation. Inhibition of MAPK … appears to be mediated by c-Raf and B-Raf-dependent inhibition of MAPK/ERK kinase. Dopamine-stimulated
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