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Matched Description: Estrone (also known as oestrone) is a weak endogenous estrogen, a steroid and minor female sex … hormone. Estrone is synthesized from cholesterol and secreted from gonads. Endoplasmic reticulum (ER) is … the place that estrone undergoes primary metabolism. Estrone sulfate and estrone glucuronide are … the conjugated product of estrone; and CYP450 can hydroxylate estrone into catechol estrogens. The

Matched Description: GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at … . Opioids close N-type voltage-operated calcium channels and open calcium-dependent inwardly rectifying … potassium channels. This results in hyperpolarization and reduced neuronal excitability. Morphine … acts at A delta and C pain fibres in the dorsal horn of the spinal cord. By decreasing neurotransmitter

Matched Description: Eletriptan binds with high affinity to 5-HT1B, 5-HT1D and 5-HT1F receptors, has modest affinity for … 5-HT1A, 5-HT1E, 5-HT2B and 5-HT7 receptors, and little or no affinity for 5-HT2A, 5-HT2C, 5-HT3, 5 … -HT4, 5-HT5A and 5-HT6 receptors. In contrast, eletriptan displays insignificant pharmacological

Matched Description: , efficacy, and tolerability for both. Terconazole is applied topically to the vagina where it is … absorbed into the infected cells, and then diffuses into the candida cell. Terconazole inhibits lanosterol … fluidity and preventing growth of new cells. This leads to cell lysis which causes it to collapse and die.

Matched Description: Enflurane is a halogenated inhalational anesthetic agent used for the induction and maintenance of … anesthesia and for analgesia during labor and delivery. In addition, it is known to cause increased … intracellular calcium available, calcium cannot readily bind to calmodulin and muscle contraction is inhibited.

Matched Description: GDP-bound and inactivate state. Caspase 3 cleaves D4-GDI into two fragments of 5 kDa and 23 kDa size … various fragments, this is a hallmark of apoptosis. PARP functions to detect and repair DNA damage … activated when released from D4-GDI upon cleavage by caspase-3. RHO GTPases mediate cytoskeleton changes leading to apoptosis and cell death. .

Matched Description: GDP-bound and inactivate state. Caspase 3 cleaves D4-GDI into two fragments of 5 kDa and 23 kDa size … various fragments, this is a hallmark of apoptosis. PARP functions to detect and repair DNA damage … activated when released from D4-GDI upon cleavage by caspase-3. RHO GTPases mediate cytoskeleton changes leading to apoptosis and cell death. .

Matched Description: ligand CD40L, also known as CD154, CD40-CD40L interaction initializes the activation and proliferation … cell surfaces such as endothelial cells, fibroblasts, hematopoietic progenitors, platelets, and basal … -kinase, signal transducers and activators of transcription, and phosphoinositide 3-kinase pathways

Matched Description: ligand CD40L, also known as CD154, CD40-CD40L interaction initializes the activation and proliferation … cell surfaces such as endothelial cells, fibroblasts, hematopoietic progenitors, platelets, and basal … -kinase, signal transducers and activators of transcription, and phosphoinositide 3-kinase pathways

Matched Description: Spermidine is formed from decarboxy-SAM and putrescine by catalyzing spermidine synthase (also … catalyzation of adenosylmethionine decarboxylase and cofactors: pyruvic acid and magnesium. The other … . coli most intracellular spermidine is bound to nucleic acids and phospholipids. (EcoCyc)