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Pathway Description
CD40L Signalling Pathway
Rattus norvegicus
Category:
Protein Pathway
Sub-Categories:
Apoptosis Signaling
Gene Regulatory
Immunological
Cellular Response
Created: 2018-09-20
Last Updated: 2019-08-16
CD40 is a part of the tumor necrosis factor (TNF) receptor superfamily. When bound to it’s main ligand CD40L, also known as CD154, CD40-CD40L interaction initializes the activation and proliferation of B lymphocytes or results in carcinoma cells apoptosis.
CD40 can be expressed on many different cell surfaces such as endothelial cells, fibroblasts, hematopoietic progenitors, platelets, and basal epithelial cells. When combined with the variety of environments CD40 presenting cells can be in, the differing effects resulting from CD40 signalling is vast. However, one characteristic all CD40 mediated signalling has in common is that instead of using kinase to mediate signal transduction, signalling is performed through downstream adapter molecules. Some pathways activated by CD40-CD40L signalling include the activation of nuclear factor-κB, p38 mitogen activated protein kinase, c-Jun-NH2-kinase, signal transducers and activators of transcription, and phosphoinositide 3-kinase pathways. All of which ultimately help regulate alterations in gene expression.
References
CD40L Signalling Pathway References
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Pubmed: 10826698
Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby P, Lee R, Boyle WJ: Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell. 1997 Apr 18;89(2):309-19. doi: 10.1016/s0092-8674(00)80209-3.
Pubmed: 9108485
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Pubmed: 15489334
Nemeth E, Bole-Feysot C, Tashima LS: Suppression subtractive hybridization (SSH) identifies prolactin stimulation of p38 MAP kinase gene expression in Nb2 T lymphoma cells: molecular cloning of rat p38 MAP kinase. J Mol Endocrinol. 1998 Feb;20(1):151-6.
Pubmed: 9513091
Shi Y, Gaestel M: In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance. Biol Chem. 2002 Oct;383(10):1519-36. doi: 10.1515/BC.2002.173.
Pubmed: 12452429
Cuadrado A, Nebreda AR: Mechanisms and functions of p38 MAPK signalling. Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
Pubmed: 20626350
Xu S, Robbins DJ, Christerson LB, English JM, Vanderbilt CA, Cobb MH: Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Proc Natl Acad Sci U S A. 1996 May 28;93(11):5291-5. doi: 10.1073/pnas.93.11.5291.
Pubmed: 8643568
Chadee DN, Yuasa T, Kyriakis JM: Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. Mol Cell Biol. 2002 Feb;22(3):737-49. doi: 10.1128/mcb.22.3.737-749.2002.
Pubmed: 11784851
Ye B, Yu WP, Thomas GM, Huganir RL: GRASP-1 is a neuronal scaffold protein for the JNK signaling pathway. FEBS Lett. 2007 Sep 18;581(23):4403-10. doi: 10.1016/j.febslet.2007.08.008. Epub 2007 Aug 14.
Pubmed: 17761173
Ryser S, Tortola S, van Haasteren G, Muda M, Li S, Schlegel W: MAP kinase phosphatase-1 gene transcription in rat neuroendocrine cells is modulated by a calcium-sensitive block to elongation in the first exon. J Biol Chem. 2001 Sep 7;276(36):33319-27. doi: 10.1074/jbc.M102326200. Epub 2001 Jun 22.
Pubmed: 11423551
Kwak SP, Hakes DJ, Martell KJ, Dixon JE: Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene. J Biol Chem. 1994 Feb 4;269(5):3596-604.
Pubmed: 8106404
Price DM, Chik CL, Terriff D, Weller J, Humphries A, Carter DA, Klein DC, Ho AK: Mitogen-activated protein kinase phosphatase-1 (MKP-1): >100-fold nocturnal and norepinephrine-induced changes in the rat pineal gland. FEBS Lett. 2004 Nov 5;577(1-2):220-6. doi: 10.1016/j.febslet.2004.09.083.
Pubmed: 15527789
Nemoto S, DiDonato JA, Lin A: Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase. Mol Cell Biol. 1998 Dec;18(12):7336-43. doi: 10.1128/mcb.18.12.7336.
Pubmed: 9819420
Wooten MW, Geetha T, Seibenhener ML, Babu JR, Diaz-Meco MT, Moscat J: The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination. J Biol Chem. 2005 Oct 21;280(42):35625-9. doi: 10.1074/jbc.C500237200. Epub 2005 Aug 3.
Pubmed: 16079148
Jobin C, Sartor RB: The I kappa B/NF-kappa B system: a key determinant of mucosalinflammation and protection. Am J Physiol Cell Physiol. 2000 Mar;278(3):C451-62. doi: 10.1152/ajpcell.2000.278.3.C451.
Pubmed: 10712233
Coli R, Anderson SL, Volpi SA, Rubin BY: Genomic organization and chromosomal localization of the mouse IKBKAP gene. Gene. 2001 Nov 14;279(1):81-9. doi: 10.1016/s0378-1119(01)00737-5.
Pubmed: 11722848
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0089759
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