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Matched Description: The pathway starts with trans-cinnamate interacting with a hydrogen ion, an oxygen molecule, and a … NADH through a cinnamate dioxygenase resulting in a NAD and a cis-3-(3-Carboxyethenyl)-3,5 … dehydrogenase resulting in the release of a hydrogen ion, an NADH molecule and a 2,3 dihydroxy-trans … -hydroxy-trans-cinnamate interacting with a hydrogen ion, a NADH and an oxygen molecule through a 3-(3 … -hydroxyphenyl)propionate 2-hydroxylase resulting in the release of a NAD molecule, a water molecule and

Matched Description: The pathway starts with trans-cinnamate interacting with a hydrogen ion, an oxygen molecule, and a … NADH through a cinnamate dioxygenase resulting in a NAD and a cis-3-(3-Carboxyethenyl)-3,5 … dehydrogenase resulting in the release of a hydrogen ion, an NADH molecule and a 2,3 dihydroxy-trans … -hydroxy-trans-cinnamate interacting with a hydrogen ion, a NADH and an oxygen molecule through a 3-(3 … -hydroxyphenyl)propionate 2-hydroxylase resulting in the release of a NAD molecule, a water molecule and

Matched Description: molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli … to bind to and hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP). When they are … bound to GTP, they are 'on', and, when they are bound to GDP, they are 'off'. G proteins belong to … to a domain of the GPCR located outside the cell, and an intracellular GPCR domain then in turn … protein-coupled receptors and G proteins working together transmit signals from many hormones

Matched Description: molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli … to bind to and hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP). When they are … bound to GTP, they are 'on', and, when they are bound to GDP, they are 'off'. G proteins belong to … to a domain of the GPCR located outside the cell, and an intracellular GPCR domain then in turn … protein-coupled receptors and G proteins working together transmit signals from many hormones

Matched Description: effects by inhibiting the synthesis of prostaglandins involved in pain, fever and inflammation. COX-2 … catalyzes the conversion of arachidonic acid to prostaglandin G2 (PGE2) and PGE2 to prostaglandin H2 … (PGH2). In the COX-2 catalyzed pathway, PGH2 is the precusor of prostaglandin E2 (PGE2) and I2 … (PGI2). PGE2 induces pain, fever, erythema and edema. Celecoxib antagonizes COX-2 by binding to the … site. Similar to other COX-2 inhibitors, such as rofecoxib and valdecoxib, celecoxib appears to

Matched Description: molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli … to bind to and hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP). When they are … bound to GTP, they are 'on', and, when they are bound to GDP, they are 'off'. G proteins belong to … to a domain of the GPCR located outside the cell, and an intracellular GPCR domain then in turn … protein-coupled receptors and G proteins working together transmit signals from many hormones

Matched Description: as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium … (5 mM) and calcium (100 nM) concentrations and high intracellular potassium (140 mM) concentrations … . Conversely, extracellular concentrations of sodium (140 mM) and calcium (1.8 mM) are relatively … high and extracellular potassium concentrations are low (5 mM). At rest, the cardiac cell membrane is … impermeable to sodium and calcium ions, but is permeable to potassium ions via inward rectifier

Matched Description: , such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular … sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium (140 mM … ) concentrations. Conversely, extracellular concentrations of sodium (140 mM) and calcium (1.8 mM) are relatively … high and extracellular potassium concentrations are low (5 mM). At rest, the cardiac cell membrane … is impermeable to sodium and calcium ions, but is permeable to potassium ions via inward rectifier

Matched Description: , such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular … sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium (140 mM … ) concentrations. Conversely, extracellular concentrations of sodium (140 mM) and calcium (1.8 mM) are relatively … high and extracellular potassium concentrations are low (5 mM). At rest, the cardiac cell membrane … is impermeable to sodium and calcium ions, but is permeable to potassium ions via inward rectifier

Matched Description: Endogenous incretins such as such as glucagon-like peptide-1 (GLP-1) and glucose-dependent … insulinotropic peptide (GIP) are hormones regulating insulin secretion and glucose metabolism in mammals … secreted by the enteroendocrine K-cells that are present in high density in the duodenum and upper … jejunum but are present throughout the small intestine. Oral ingestion and subsequent absorption of … nutrients such as glucose, high amounts of amino acids, and long-chain fatty acids trigger the secretion