SMP0471943
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Uracil Degradation III
Grimontia hollisae CIP 101886
Matched Description: Uracil is a pyrimidine nucleobase found in RNA, and can be used as a source of nitrogen for E. coli … broken down into both carbamic acid and 3-aminoacrylate following the addition of a water molecule by the … addition of a hydrogen ion, split into an ammonium ion and a molecule of carbon dioxide. 3-aminoacrylate … compound enters into a reaction catalyzed by protein rutD, which adds a water molecule and hydrogen ion … and forms malonic semialdehyde with ammonium being a byproduct. Finally, the putative NADH
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SMP0100345
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Phosphatidylcholine/Phosphatidylethanolamine Biosynthesis PC(18:2(9Z,12Z)/22:0) | PE(18:2(9Z,12Z)/22:0)
Drosophila melanogaster
Matched Description: and has both structural and signalling roles. In eukaryotes, there exist two phosphatidylcholine … biosynthesis pathways: the Kennedy pathway and the methylation pathway. The Kennedy pathway begins … -choline and subsequently phosphatidylcholine. It is the major synthesis route in animals. In the … diacylglycerol backbone. They are the second most abundant phospholipid in eukaryotic cell membranes, and
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SMP0120551
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DOPA-Responsive Dystonia
Mus musculus
Matched Description: DOPA-Responsive Dystonia is a condition in which the muscles contract, experience tremors and … of this condition are dystonia in the legs, and clubfeet. The cause of this condition is usually a … and serotonin, and the processing of quite a few amino acids, The mutation on GCH1 causes GTP … why patients with DOPA-responive dystonia experience tremors and movement problems.
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SMP0125832
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Sulconazole Action Pathway
Homo sapiens
Matched Description: , and tinea versicolor caused by susceptible fungal strains. It is known by the brand name Exelderm … available as a topical cream and solution. Sulconazole nitrate, the active ingredient, is an imidazole … treatment for tinea cruris and tinea corporis infections.
The exact mechanism of action of sulconazole is … membranes thereby increasing fluidity and preventing growth of new cells. This leads to cell lysis which causes it to collapse and die.
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SMP0125842
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Griseofulvin Action Pathway
Homo sapiens
Matched Description: Griseofulvin is an antifungal agent used to treat ringworm infections of the skin, hair, and nails … Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been … species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other … is not clear, but it is thought to inhibit fungal cell mitosis and nuclear acid synthesis. At the … , likely inhibiting mytosis and preventing further growth of fungal cells.
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SMP0127694
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Gs Serotonergic Smooth Muscle Contraction
Rattus norvegicus
Matched Description: contraction in the GI tract. This increased contractility promotes peristalsis and enhances gastric … emptying by propelling food and digestive contents through the GI tract. Specifically, Gs proteins … -dependent protein kinase A (PKA) and other cAMP-responsive proteins. Signaling through G protein-coupled … , growth, and "synthetic" functions that orchestrate airway inflammation and promote remodeling of airway architecture.
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SMP0126825
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Benzhydrocodone Opioid Agonist Action Pathway
Homo sapiens
Matched Description: adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease … neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids close … N-type voltage-operated calcium channels and open calcium-dependent inwardly rectifying potassium … channels. This results in hyperpolarization and reduced neuronal excitability. Morphine acts at A … delta and C pain fibres in the dorsal horn of the spinal cord. By decreasing neurotransmitter action
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SMP0126897
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Gadobenic Metabolism
Homo sapiens
Matched Description: MR imaging of the liver. It can also be used for visualizing the CNS and heart. In contrast to … conventional extracellular fluid contrast agents, gadobenate dimeglumine is characterized by a weak and … gadobenate dimeglumine and, consequently, to a considerably increased signal intensity over that of other … central nervous system in adult and pediatric patients in order to visualize lesions with abnormal blood … -brain barrier or abnormal vascularity of the brain, spine, and associated tissues. It is also
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SMP0002391
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Ether Lipid Metabolism
Saccharomyces cerevisiae
Matched Description: The metabolism of ether lipids can begin with 1-O-Hexadecyl-2-O-acetyl-sn-glycerol and citicoline … alpha resulting in the release of acetic acid, hydrogen ion and lysoPAF. The latter compound can react … acyltransferase resulting in the release of water and 1-O-Palmityl-2-palmitoyl-rac-glycero-3 … -Palmityl-2-palmitoyl-rac-glycero-3-phosphocholine and Cytidine monophosphate. 1-O-Hexadecyl-2 … cholinephosphotransferase/ethanolaminephosphotransferase resulting in the release of 1-hexadecyl-2-palmitoyl-glycero-3-phosphoethanolamine and Cytidine monophosphate
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SMP0014204
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Monoterpenoid Biosynthesis
Arabidopsis thaliana
Matched Description: monoterpenoid biosynthesis take place in the chloroplast and require either magnesium or manganese ions as … . Two different enzymes can function as myrcene synthases and catalyze the conversion of geranyl … diphosphate into myrcene: tricyclene synthase and beta-myrcene/(E)-beta-ocimene synthase 2. 1,8-cineole … geranyl diphosphate into alpha-terpineol and the conversion of alpha-terpineol into eucalyptol (1,8 … , (-)-alpha-pinene, sabinene and terpinolene, all with varying frequency. Additionally, (E,E)-alpha
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