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Search for '肿瘤综合治疗电子杂志 胃癌治疗进展 2024第10卷第1期' in 'all pathways' in 'all species' returned 402035 results

SMP0000642

Pw000618 View Pathway
Metabolite

Nevirapine Metabolism Pathway

Homo sapiens

  • Matched Description: Nevirapine is used in the treatment of human immunodeficiency virus (HIV) type 1 (HIV-1) infection … acid residues 181 and 188 of HIV-1 reverse transcriptase. Nevirapine is metabolized in the liver to

  • Matched Proteins: UDP-glucuronosyltransferase 1-10 … Retinal dehydrogenase 1

  • Matched Protein Synonyms: UDPGT 1-10 … UDPGT 1-10 … UDPGT 1-10 … UDPGT 1-10 … Cytochrome P450 PB-1

  • Matched Compound Synonyms: 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide … Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-d-ribofuranosyl-3-pyridinecarboxamide … Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Metabolism

    SMP0000544

    Pw000520 View Pathway
    Metabolite

    Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD)

    Homo sapiens

  • Matched Description: prevalence of LCHADD is 1 in 62 000 in Northern European individuals. The worldwide birth prevalence is … estimated at 1 in 250 000. MCADD is an autosomal recessive disorder associated with a mutation in the

  • Matched Proteins: Palmitoyl-protein thioesterase 1

  • Matched Protein Synonyms: 17-beta-hydroxysteroid dehydrogenase 10 … Enoyl-CoA hydratase 1 … HsNrbf-1 … NRBF-1 … Nuclear receptor-binding factor 1

  • Matched Compound Synonyms: 3-carbamoyl-1-beta-delta-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate inner salt … 3-carbamoyl-1-d-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate … 3-carbamoyl-1-delta-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Disease

    SMP0125748

    Pw127315 View Pathway
    Metabolite

    Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (Fatty Acid Elongation in Mitochondria)

    Homo sapiens

  • Matched Description: prevalence of LCHADD is 1 in 62 000 in Northern European individuals. The worldwide birth prevalence is … estimated at 1 in 250 000. MCADD is an autosomal recessive disorder associated with a mutation in the

  • Matched Proteins: Palmitoyl-protein thioesterase 1

  • Matched Protein Synonyms: 17-beta-hydroxysteroid dehydrogenase 10 … Enoyl-CoA hydratase 1 … HsNrbf-1 … NRBF-1 … Nuclear receptor-binding factor 1

  • Matched Compound Synonyms: 3-carbamoyl-1-beta-delta-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate inner salt … 3-carbamoyl-1-d-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate … 3-carbamoyl-1-delta-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Disease

    SMP0000054

    Pw000022 View Pathway
    Metabolite

    Fatty Acid Elongation in Mitochondria

    Homo sapiens

  • Matched Proteins: Palmitoyl-protein thioesterase 1

  • Matched Protein Synonyms: 17-beta-hydroxysteroid dehydrogenase 10 … Enoyl-CoA hydratase 1 … HsNrbf-1 … NRBF-1 … Nuclear receptor-binding factor 1

  • Matched Compound Synonyms: 3-carbamoyl-1-beta-delta-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate inner salt … 3-carbamoyl-1-d-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate … 3-carbamoyl-1-delta-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Metabolic

    SMP0000600

    Pw000576 View Pathway
    Metabolite

    Irinotecan Metabolism Pathway

    Homo sapiens

  • Matched Proteins: UDP-glucuronosyltransferase 1-10 … DNA topoisomerase 1 … Multidrug resistance protein 1 … Multidrug resistance-associated protein 1 … Canalicular multispecific organic anion transporter 1

  • Matched Protein Synonyms: UDPGT 1-10 … LST-1 … CE-1 … ATP-binding cassette sub-family C member 1 … ATP-binding cassette sub-family B member 1

  • Matched Compound Synonyms: A-d-glucopyranuronic acid 1->5'-ester with uridine 5'-(trihydrogen pyrophosphate) … Alpha-d-glucopyranuronic acid 1-p'-ester with uridine 5'-(trihydrogen diphosphate) … Alpha-delta-glucopyranuronic acid 1->5'-ester with uridine 5'-(trihydrogen pyrophosphate) … Alpha-delta-glucopyranuronic acid 1-p'-ester with uridine 5'-(trihydrogen diphosphate) … Glucopyranuronic acid 1-ester with uridine 5'-pyrophosphate

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Metabolism

    SMP0000096

    Pw000138 View Pathway
    Metabolite

    Celecoxib metabolism Pathway

    Homo sapiens

  • Matched Description: exploit slight differences in the size of the COX-1 and -2 binding pockets to gain selectivity. COX-1 … COX-1 adds enough bulk to proclude celecoxib from binding. Celecoxib is approximately ten times more … selective for COX-2 than COX-1. Celecoxib is used mainly to treat rheumatoid arthritis and … derived from fragmentation of megakaryocytes, contain COX-1, but not COX-2. COX-1 activity in platelets … both COX-1 and COX-2. COX-2 in endothelial cells mediates the synthesis of PGI2, an effective

  • Matched Proteins: UDP-glucuronosyltransferase 1-10 … Prostaglandin G/H synthase 1 … Leukotriene-B(4) omega-hydroxylase 1 … Gamma-glutamyltranspeptidase 1 … Glutathione peroxidase 1

  • Matched Protein Synonyms: UDPGT 1-10 … COX-1 … Gamma-glutamyltranspeptidase 1 heavy chain … UGT1-10 … Prostaglandin-endoperoxide synthase 1

  • Matched Compound Synonyms: P-(5-p-tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulphonamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide … Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-d-ribofuranosyl-3-pyridinecarboxamide … Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide

  • Matched EC Numbers: 1.-.-.-; 1.1.1.357; 1.1.1.112; 1.1.1.188; 1.1.1.239; 1.1.1.64; 1.3.1.20

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Metabolic

    SMP0000086

    Pw000131 View Pathway
    Metabolite

    Ibuprofen Action Pathway

    Homo sapiens

  • Matched Compounds: 1-Hydroxyibuprofen

  • Matched Proteins: UDP-glucuronosyltransferase 1-10 … Prostaglandin G/H synthase 1 … Stromal cell-derived factor 2-like protein 1 … UDP-glucuronosyltransferase 1-1 … UDP-glucuronosyltransferase 1-3

  • Matched Protein Synonyms: UDPGT 1-10 … PGH synthase 1 … Gamma-glutamyltranspeptidase 1 light chain … PHS 1 … Prostaglandin H2 synthase 1

  • Matched Compound Synonyms: 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide … Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-d-ribofuranosyl-3-pyridinecarboxamide … Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide

  • Matched EC Numbers: 1.-.-.-; 1.1.1.357; 1.1.1.112; 1.1.1.188; 1.1.1.239; 1.1.1.64; 1.3.1.20

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0125810

    Pw127378 View Pathway
    Metabolite

    Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (HADH)

    Homo sapiens

  • Matched Description: effective. It is estimated that HADH deficiency affects less than 1 in 1,000,000 individuals.

  • Matched Protein Synonyms: Enoyl-CoA hydratase 1 … 17-beta-HSD 10 … 17-beta-hydroxysteroid dehydrogenase 10 … Enoyl-CoA hydratase 1 … 17-beta-HSD 10

  • Matched Compound Synonyms: 1-hexanoic acid … 1-pentanecarboxylic acid … 1-hexanoate … 1-pentanecarboxylate … 3-carbamoyl-1-beta-d-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate inner salt

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Disease

    SMP0000480

    Pw000171 View Pathway
    Metabolite

    Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids

    Homo sapiens

  • Matched Protein Synonyms: Enoyl-CoA hydratase 1 … 17-beta-HSD 10 … 17-beta-hydroxysteroid dehydrogenase 10 … Enoyl-CoA hydratase 1 … 17-beta-HSD 10

  • Matched Compound Synonyms: 1-hexanoic acid … 1-pentanecarboxylic acid … 1-hexanoate … 1-pentanecarboxylate … 1-hexanoic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Metabolic

    SMP0000568

    Pw000544 View Pathway
    Metabolite

    Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (HADH)

    Homo sapiens

  • Matched Description: effective. It is estimated that HADH deficiency affects less than 1 in 1,000,000 individuals.

  • Matched Protein Synonyms: Enoyl-CoA hydratase 1 … 17-beta-HSD 10 … 17-beta-hydroxysteroid dehydrogenase 10 … Enoyl-CoA hydratase 1 … 17-beta-HSD 10

  • Matched Compound Synonyms: 1-hexanoic acid … 1-pentanecarboxylic acid … 1-hexanoate … 1-pentanecarboxylate … 1-hexanoic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Disease