Quantitative metabolomics services for biomarker discovery and validation.
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GTP- cyclohydrolase I FOLic acid synthesis FOLic acid synthesis FOLic acid synthesis aminodeoxychorismate lyase Aminodeoxychorismate synthase FOLic acid synthesis 3 dihydrofolate reductase glycinamide ribotide transformylase mitochondrial C1- tetrahydrofolate synthase Guanosine triphosphate H2O Formic acid H+ Dihydroneopterin triphosphate H2O Dihydroneopterin phosphate PPi H+ H2O 7,8- Dihydroneopterin Pi Glycolaldehyde 6- hydroxymethyl- 7,8- dihydropterin ATP AMP H+ 6- hydroxymethyl- 7,8- dihydropterin diphosphate p-Aminobenzoic acid PPi 7,8- Dihydropteroic acid 4-amino-4- deoxychorismate H+ Pyruvic acid Chorismate L-Glutamine L-Glutamic acid ATP L-Glutamic acid ADP Pi H+ 7,8-dihydrofolate monoglutamate H+ NADPH NADP Tetrahydrofolate 10- Formyltetrahydrofolate 5'- Phosphoribosyl- N- formylglycinamide 5'- Phosphoribosyl- N- formylglycinamide 5,10- Methenyltetrahydrofolic acid H2O H+ Mitochondria
Mitochondria FOL2 FOL1 FOL1 FOL1 ABZ2 ABZ1 FOL3 DFR1 ADE8 MIS1 Guanosine triphosphate Water Formic acid Hydrogen Ion Dihydroneopterin triphosphate Water Dihydroneopterin phosphate Pyrophosphate Hydrogen Ion Water 7,8- Dihydroneopterin Phosphate Glycolaldehyde 6- hydroxymethyl- 7,8- dihydropterin Adenosine triphosphate Adenosine monophosphate Hydrogen Ion 6- hydroxymethyl- 7,8- dihydropterin diphosphate p-Aminobenzoic acid Pyrophosphate 7,8- Dihydropteroic acid 4-amino-4- deoxychorismate Hydrogen Ion Pyruvic acid Chorismate L-Glutamine L-Glutamic acid Adenosine triphosphate L-Glutamic acid Adenosine diphosphate Phosphate Hydrogen Ion 7,8-dihydrofolate monoglutamate Hydrogen Ion NADPH NADP Tetrahydrofolate 10- Formyltetrahydrofolate 5'- Phosphoribosyl- N- formylglycinamide 5'- Phosphoribosyl- N- formylglycinamide 5,10- Methenyltetrahydrofolic acid Water Hydrogen Ion