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Pathway Description
Tyrosine Metabolism
Saccharomyces cerevisiae
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2016-02-01
Last Updated: 2025-01-25
The biosynthesis of tyrosine begins with chorismate interacting with chorismate mutase resulting in a prephenate. Prephenate reacts with a hydrogen ion through a prephenate dehydratase resulting in the release of NADPH, carbon dioxide and 4-hydroxyphenylpyruvate. The latter compound can be turn into tyrosine through two different reversible reactions a) 4-hydroxyphenylpyruvate reacts with alanine through a aromatic amino acid aminotransferase 2 resulting in the release of pyruvate and phenylalanine. b) 4-hydroxyphenylpyruvatereacts with glutamic acid through a amino aci aminotransferase 1 resulting in the release of oxoglutaric acid and phenylalanine. The degradation of phenylalanine begins with the two previous reactions turning phenylalanine back into 4-hydroxyphenylpyruvate. The latter compound reacts with a phenylpyruvate carboxy lyase resulting in the release of phenylacetaldehyde. This latter compound reacts with a alcohol dehydrogenase resulting in the release of tyrosol.
References
Tyrosine Metabolism References
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Pubmed: 1943992
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Pubmed: 9491083
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Pubmed: 8091229
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Pubmed: 3537965
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Pubmed: 2185016
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Pubmed: 10338141
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Hohmann S: Characterization of PDC6, a third structural gene for pyruvate decarboxylase in Saccharomyces cerevisiae. J Bacteriol. 1991 Dec;173(24):7963-9. doi: 10.1128/jb.173.24.7963-7969.1991.
Pubmed: 1744053
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Pubmed: 12423374
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