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Pathway Description
Tryptophan Metabolism
Saccharomyces cerevisiae
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2016-02-01
Last Updated: 2019-08-14
The tryptophan biosynthesis begins with chorismate interacting with a L-glutamine through a Anthranilate synthase resulting in the release of glutamic acid, pyruvic acid, hydrogen ion and 2-aminobenzoic acid. The latter compound reacts with a PRPP through an Anthranilate phosphoribosyltransferase resulting in the release of pyrophosphate and a N-5-phosphoribosyl anthranilate. The latter compound is isomerized through a N-5 phosphoribosylanthranilate isomerase resulting in the release of a 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate which then reacts with a hydrogen ion resulting in the release of water, carbon dioxide and indoleglycerol phosphate. The latter compound reacts with a tryptophan synthase resulting in the release of D-glyceraldehyde 3-phosphate and Indole. Indole reacts with L-serine through a tryptophan synthase resulting in the release of water and tryptophan.
The degradation of tryptophan can occur in 2 ways:
a) tryptophan reacting with an aromatic aminotransferase resulting in the release of indole 3 pyruvate which can then be transformed into indoleacetaldehyde through a pyruvate isozyme. Indoleacetaldehyde reacts with alcohol dehydrogenase resulting in a tryptophol
B) tryptophan is consumed through the nicotinate biosynthesis
References
Tryptophan Metabolism References
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Pubmed: 2428012
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Pubmed: 8840504
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Pubmed: 7813418
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