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Anthranilate synthase component 1 Multifunctional tryptophan biosynthesis protein Anthranilate phosphoribosyltransferase N-(5'- phosphoribosyl)anthranilate isomerase Tryptophan synthase Kynurenine formamidase Kynurenine 3-monooxygenase Kynureninase Kynureninase 3- hydroxyanthranilate 3,4-dioxygenase aromatic amino acid aminotransferase II Pyruvate decarboxylase isozyme 1 pyruvate decarboxylase 2 Pyruvate decarboxylase isozyme 3 alcohol dehydrogenase subunit I alcohol dehydrogenase subunit 2 Tryptophan synthase Indoleamine 2,3-dioxygenase Aromatic/aminoadipate aminotransferase 1 Chorismate L-Glutamine Pyruvic acid L-Glutamic acid H+ 2-Aminobenzoic acid Phosphoribosyl pyrophosphate PPi N-(5- phosphoribosyl)- anthranilate 1-(2- carboxyphenylamino)- 1-deoxy-D- ribulose 5-phosphate H+ H2O CO2 Indoleglycerol phosphate Indole D- Glyceraldehyde 3-phosphate N'- Formylkynurenine H2O Formic acid H+ L-Kynurenine H+ NADPH O2 3-hydroxy-L- kynurenine NADP H2O H2O H+ L-Alanine 2-Aminobenzoic acid H2O L-Alanine H+ 3- Hydroxyanthranilic acid O2 H+ 2-Amino-3- carboxymuconic acid semialdehyde L-Tryptophan 2-Oxo-3- phenylpropanoic acid (Mixture oxo and keto) indole-3- pyruvate L-Phenylalanine H+ Indoleacetaldehyde CO2 NADH H+ NAD Tryptophol L-Serine H2O O2 Oxoglutaric acid L-Glutamic acid