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Pathway Description
Selenocompound Metabolism
Saccharomyces cerevisiae
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2016-02-19
Last Updated: 2019-08-14
The the metabolism of selenocompounds starts with Selenocysteine being metabolized by a CGS resulting in the release of Seleno-cystathionine. The resulting compound is metabolized by a CBL resulting in the release of selenohomocysteine. The resulting compound reacts with MET resulting in the release of a seleno-methionine. Selenomethionine can be either metabolized into Seleno-methionyl-tRNA or a Methyl-selenol.
Methyl-selenol can also be the result of Methyl-selenic acid reacting with a thioredoxin reductase or Se-methyl-selenocysteine reacting through a CTH.
References
Selenocompound Metabolism References
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Pubmed: 9169869
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Pubmed: 6341994
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Pubmed: 3905796
Clemente ML, Sartori G, Cardazzo B, Carignani G: Analysis of an 11.6 kb region from the right arm of chromosome VII of Saccharomyces cerevisiae between the RAD2 and the MES1 genes reveals the presence of three new genes. Yeast. 1997 Mar 15;13(3):287-90. doi: 10.1002/(SICI)1097-0061(19970315)13:3<287::AID-YEA75>3.0.CO;2-5.
Pubmed: 9090059
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Pubmed: 1577698
Yamagata S, D'Andrea RJ, Fujisaki S, Isaji M, Nakamura K: Cloning and bacterial expression of the CYS3 gene encoding cystathionine gamma-lyase of Saccharomyces cerevisiae and the physicochemical and enzymatic properties of the protein. J Bacteriol. 1993 Aug;175(15):4800-8. doi: 10.1128/jb.175.15.4800-4808.1993.
Pubmed: 8335636
Barton AB, Kaback DB, Clark MW, Keng T, Ouellette BF, Storms RK, Zeng B, Zhong W, Fortin N, Delaney S, et al.: Physical localization of yeast CYS3, a gene whose product resembles the rat gamma-cystathionase and Escherichia coli cystathionine gamma-synthase enzymes. Yeast. 1993 Apr;9(4):363-9. doi: 10.1002/yea.320090406.
Pubmed: 8511966
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Pubmed: 9169868
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Pubmed: 8686379
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Pubmed: 9046087
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Pubmed: 8641269
Hu Y, Rolfs A, Bhullar B, Murthy TV, Zhu C, Berger MF, Camargo AA, Kelley F, McCarron S, Jepson D, Richardson A, Raphael J, Moreira D, Taycher E, Zuo D, Mohr S, Kane MF, Williamson J, Simpson A, Bulyk ML, Harlow E, Marsischky G, Kolodner RD, LaBaer J: Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae. Genome Res. 2007 Apr;17(4):536-43. doi: 10.1101/gr.6037607. Epub 2007 Feb 23.
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Pubmed: 7961686
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Pubmed: 9169867
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