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Pathway Description
Sphingolipid Metabolism
Saccharomyces cerevisiae
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2016-02-22
Last Updated: 2025-03-14
Sphingolipids have important structural and functional roles. They can be associated with membrane cholesterol and assist in forming specialized membrane domains. Sphingolipids, similar to phospholipids, have a polar head group with two nonpolar tails. Sphingolipids differ from phospholipids by their sphingosine core, a long-chain amino alcohol. sphingomyelins and glycosphingolipids are sphingolipids. Sphingolipids are produced in the endoplasmic reticulum. Sphinoglipid synthesis begins with palmitoyl-CoA and serine producing 3-keto-dihydrosphingosine by serine palmitoyltransferase. 3-Keto-dihydrosphingosine is then reduced to dihydrosphingosine which is then acylated to form dihydroceramide. Dihydroceramide is then dehyrogenated to ceramide. Ceramides are a sphingosine and fatty acid connected by an amide bond and can be produced by metabolism of sphingolipids. Ceramide can also be broken down back to sphingosine. Ceramide gets transported to the Golgi where it forms sphingomyelin or glycosphingolipids. From the Golgi, these products are transported by vesicles to specialized membrane domains.
References
Sphingolipid Metabolism References
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Salway, J.G. Metabolism at a glance (3rd ed.) (2004). Alden, Mass.: Blackwell Pub.
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Pubmed: 11694577
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Pubmed: 12151215
Boyer J, Pascolo S, Richard GF, Dujon B: Sequence of a 7.8 kb segment on the left arm of yeast chromosome XI reveals four open reading frames, including the CAP1 gene, an intron-containing gene and a gene encoding a homolog to the mammalian UOG-1 gene. Yeast. 1993 Mar;9(3):279-87. doi: 10.1002/yea.320090307.
Pubmed: 8488728
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Pubmed: 8196765
Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995.
Pubmed: 24374639
Cliften P, Wang Y, Mochizuki D, Miyakawa T, Wangspa R, Hughes J, Takemoto JY: SYR2, a gene necessary for syringomycin growth inhibition of Saccharomyces cerevisiae. Microbiology. 1996 Mar;142 ( Pt 3):477-84. doi: 10.1099/13500872-142-3-477.
Pubmed: 8868422
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Pubmed: 9169867
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