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Pathway Description
Valine Degradation
Saccharomyces cerevisiae
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2016-02-29
Last Updated: 2019-08-14
The degradation of valine starts either in the mitochondria or the cytosol. L-valine reacts with 2-oxoglutarate through a branch-chain amino acid aminotransferase resulting in the release of L-glutamate and 3-methyl-2-oxobutanoate. The latter compound reacts with 2-oxoisovalerate carboxy-lyase resulting in the release of carbon dioxide and isobutanal. Isobutanal can then be turned into isobutanol through a alcohol dehydrogenase
References
Valine Degradation References
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Pubmed: 1478472
Dickinson JR, Norte V: A study of branched-chain amino acid aminotransferase and isolation of mutations affecting the catabolism of branched-chain amino acids in Saccharomyces cerevisiae. FEBS Lett. 1993 Jul 12;326(1-3):29-32.
Pubmed: 8325383
Dickinson JR, Harrison SJ, Hewlins MJ: An investigation of the metabolism of valine to isobutyl alcohol in Saccharomyces cerevisiae. J Biol Chem. 1998 Oct 2;273(40):25751-6.
Pubmed: 9748245
Vuralhan Z, Morais MA, Tai SL, Piper MD, Pronk JT: Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae. Appl Environ Microbiol. 2003 Aug;69(8):4534-41.
Pubmed: 12902239
Kispal G, Steiner H, Court DA, Rolinski B, Lill R: Mitochondrial and cytosolic branched-chain amino acid transaminases from yeast, homologs of the myc oncogene-regulated Eca39 protein. J Biol Chem. 1996 Oct 4;271(40):24458-64. doi: 10.1074/jbc.271.40.24458.
Pubmed: 8798704
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Pubmed: 8091229
Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995.
Pubmed: 24374639
Galibert F, Alexandraki D, Baur A, Boles E, Chalwatzis N, Chuat JC, Coster F, Cziepluch C, De Haan M, Domdey H, Durand P, Entian KD, Gatius M, Goffeau A, Grivell LA, Hennemann A, Herbert CJ, Heumann K, Hilger F, Hollenberg CP, Huang ME, Jacq C, Jauniaux JC, Katsoulou C, Karpfinger-Hartl L, et al.: Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. EMBO J. 1996 May 1;15(9):2031-49.
Pubmed: 8641269
Kellermann E, Seeboth PG, Hollenberg CP: Analysis of the primary structure and promoter function of a pyruvate decarboxylase gene (PDC1) from Saccharomyces cerevisiae. Nucleic Acids Res. 1986 Nov 25;14(22):8963-77. doi: 10.1093/nar/14.22.8963.
Pubmed: 3537965
Hohmann S, Cederberg H: Autoregulation may control the expression of yeast pyruvate decarboxylase structural genes PDC1 and PDC5. Eur J Biochem. 1990 Mar 30;188(3):615-21. doi: 10.1111/j.1432-1033.1990.tb15442.x.
Pubmed: 2185016
Liesen T, Hollenberg CP, Heinisch JJ: ERA, a novel cis-acting element required for autoregulation and ethanol repression of PDC1 transcription in Saccharomyces cerevisiae. Mol Microbiol. 1996 Aug;21(3):621-32. doi: 10.1111/j.1365-2958.1996.tb02570.x.
Pubmed: 8866484
Muller EH, Richards EJ, Norbeck J, Byrne KL, Karlsson KA, Pretorius GH, Meacock PA, Blomberg A, Hohmann S: Thiamine repression and pyruvate decarboxylase autoregulation independently control the expression of the Saccharomyces cerevisiae PDC5 gene. FEBS Lett. 1999 Apr 23;449(2-3):245-50. doi: 10.1016/s0014-5793(99)00449-4.
Pubmed: 10338141
Johnston M, Hillier L, Riles L, Albermann K, Andre B, Ansorge W, Benes V, Bruckner M, Delius H, Dubois E, Dusterhoft A, Entian KD, Floeth M, Goffeau A, Hebling U, Heumann K, Heuss-Neitzel D, Hilbert H, Hilger F, Kleine K, Kotter P, Louis EJ, Messenguy F, Mewes HW, Hoheisel JD, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome XII. Nature. 1997 May 29;387(6632 Suppl):87-90.
Pubmed: 9169871
Hohmann S: Characterization of PDC6, a third structural gene for pyruvate decarboxylase in Saccharomyces cerevisiae. J Bacteriol. 1991 Dec;173(24):7963-9. doi: 10.1128/jb.173.24.7963-7969.1991.
Pubmed: 1744053
Tettelin H, Agostoni Carbone ML, Albermann K, Albers M, Arroyo J, Backes U, Barreiros T, Bertani I, Bjourson AJ, Bruckner M, Bruschi CV, Carignani G, Castagnoli L, Cerdan E, Clemente ML, Coblenz A, Coglievina M, Coissac E, Defoor E, Del Bino S, Delius H, Delneri D, de Wergifosse P, Dujon B, Kleine K, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. Nature. 1997 May 29;387(6632 Suppl):81-4.
Pubmed: 9169869
Oliver SG, van der Aart QJ, Agostoni-Carbone ML, Aigle M, Alberghina L, Alexandraki D, Antoine G, Anwar R, Ballesta JP, Benit P, et al.: The complete DNA sequence of yeast chromosome III. Nature. 1992 May 7;357(6373):38-46. doi: 10.1038/357038a0.
Pubmed: 1574125
Larroy C, Pares X, Biosca JA: Characterization of a Saccharomyces cerevisiae NADP(H)-dependent alcohol dehydrogenase (ADHVII), a member of the cinnamyl alcohol dehydrogenase family. Eur J Biochem. 2002 Nov;269(22):5738-45. doi: 10.1046/j.1432-1033.2002.03296.x.
Pubmed: 12423374
Bowman S, Churcher C, Badcock K, Brown D, Chillingworth T, Connor R, Dedman K, Devlin K, Gentles S, Hamlin N, Hunt S, Jagels K, Lye G, Moule S, Odell C, Pearson D, Rajandream M, Rice P, Skelton J, Walsh S, Whitehead S, Barrell B: The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII. Nature. 1997 May 29;387(6632 Suppl):90-3.
Pubmed: 9169872
Valencia E, Rosell A, Larroy C, Farres J, Biosca JA, Fita I, Pares X, Ochoa WF: Crystallization and preliminary X-ray analysis of NADP(H)-dependent alcohol dehydrogenases from Saccharomyces cerevisiae and Rana perezi. Acta Crystallogr D Biol Crystallogr. 2003 Feb;59(Pt 2):334-7. doi: 10.1107/s090744490201661x. Epub 2003 Jan 23.
Pubmed: 12554944
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