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Pathway Description
Glutamic Acid Metabolism
Arabidopsis thaliana
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2016-05-03
Last Updated: 2019-08-14
The metabolism of glutamic acid can start either in the chloroplast or in the mitochondria. This is done through a oxoglutaric acid reacting with a ferredoxin-dependent glutamic acid synthase resulting in the release of L-glutamic acid. Other reactions also involving oxoglutaric acid conversion to l-glutamic acid are: in the chloroplast: Oxoglutaric acid, glutamine , NADH and Hydrogen ion react through a glutamate synthase [NADH] resulting in the release of NAD and L-glutamic acid.
in the mitochondria:
Oxoglutaric acid, ammonium and NADPH react with a glutamate dehydrogenase 3 resulting in the release of NADP, water and L-glutamic acid.
Oxoglutaric acid, ammonium and NADPH react with a glutamate dehydrogenase 1 & 2 resulting in the release of nNADP, water and L-glutamic acid.
L-glutamic acid is degraded back to glutamine and oxoglutaric acid or it reacts with glutamate decarboxylase complex resulting in the release of gamma aminobutyric acid. The latter compound reacts with a either an oxoglutaric aci or a pyruvic acid through a Gamma-aminobutyrate transaminase POP2 resulting in the release of l-glutamic acid and succinic acid semialdehyde or l-alanine and succinic acid semialdehyde.. Succinic acid semialdehyde can react to a water molecule and NAD through a succinate-semialdehyde dehydrogenase resulting in the release of NADH, a hydrogen ion and succinic acid. Succinic acid semialdehyde can also react with a hydrogen ion and an NADPH through a glyoxylate/succinic semialdehyde reductase resulting in the release of NADP and 4-hydroxybutyric acid.
References
Glutamic Acid Metabolism References
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