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Pathway Description
Tropane, Piperidine, and Pyridine Alkaloid Biosynthesis
Arabidopsis thaliana
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2017-12-08
Last Updated: 2019-09-12
Tropane, piperidine, and pyridine alkaloids are alkaloid compounds found in some plants containing a tropane, piperidine, or pyridine ring respectively . In Arabidopsis thaliana, the tropane, piperidine and pyridine alkaloid biosynthesis pathway consists of several separate reactions that are known. L-phenylalanine, which may be sourced from the phenylalanine, tyrosine, and tryptophan biosynthesis pathway or the phenylalanine metabolism pathway, may reversibly react with oxoglutaric acid to produce phenylpyruvate (aka. 2-oxo-3-phenylpropanoic acid) and L-glutamic acid. This reaction may be catalyzed by tyrosine aminotransferase, aspartate aminotransferase, or histidinol phosphate aminotransferase. Primary amine oxidase may catalyze the reactions of N-methylputrescine or cadaverine with oxygen and hydrogen to produce hydrogen peroxide, ammonia, and either 1-methylpyrrolinium or 5-aminopentanal respectively. Tropinone may react with hydrogen and NADPH to produce tropine and NADP, with catalyzation by tropinone reductase.
References
Tropane, Piperidine, and Pyridine Alkaloid Biosynthesis References
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Pubmed: 10617198
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