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Estrogen
sulfotransferase,
testis isoform
Cytochrome P450
1A1
Catechol O-
methyltransferase
UDP-
glucuronosyltransferase
1-1
UDP-
glucuronosyltransferase
1-1
Estradiol
17-beta-
dehydrogenase 1
Cytochrome P450
3A13
Estradiol
17-beta-
dehydrogenase 1
Cytochrome P450
3A13
Estrone
Phosphoadenosine
phosphosulfate
Estrone sulfate
Adenosine
3',5'-
diphosphate
H
+
O
2
NADH
2-
Hydroxyestrone
NAD
H
2
O
S-
Adenosylmethionine
2-
Methoxyestrone
S-
Adenosylhomocysteine
Uridine
diphosphate
glucuronic acid
2-
Methoxyestrone
3-glucuronide
Uridine
5'-diphosphate
Uridine
diphosphate
glucuronic acid
Estrone
glucuronide
Uridine
5'-diphosphate
NADPH
H
+
Estradiol
NADP
H
+
O
2
NADPH
NADP
H
2
O
16a-
Hydroxyestrone
NADH
H
+
Estriol
NAD
H
+
O
2
NADPH
NADP
H
2
O
Heme
Magnesium
Heme
Heme
Cytosol
Endoplasmic Reticulum
Membrane
Endoplasmic Reticulum
Sult1e1
Cyp1a1
Comt
Erp29
Erp29
Hsd17b1
Cyp3a13
Hsd17b1
Cyp3a13
Estrone
Phosphoadenosine
phosphosulfate
Estrone sulfate
Adenosine
3',5'-
diphosphate
Hydrogen Ion
Oxygen
NADH
2-
Hydroxyestrone
NAD
Water
S-
Adenosylmethionine
2-
Methoxyestrone
S-
Adenosylhomocysteine
Uridine
diphosphate
glucuronic acid
2-
Methoxyestrone
3-glucuronide
Uridine
5'-diphosphate
Uridine
diphosphate
glucuronic acid
Estrone
glucuronide
Uridine
5'-diphosphate
NADPH
Hydrogen Ion
Estradiol
NADP
Hydrogen Ion
Oxygen
NADPH
NADP
Water
16a-
Hydroxyestrone
NADH
Hydrogen Ion
Estriol
NAD
Hydrogen Ion
Oxygen
NADPH
NADP
Water