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Pathway Description
Ascorbate Biosynthesis
Mus musculus
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2018-07-26
Last Updated: 2023-10-25
L-Ascorbate commonly known as vitamin C is a reducing agent and cofactor in reactions catalyzed by copper-dependent monooxygenases and iron-dependent dioxygenases. It is synthesized from direct hydrolysis of UDP-α-D-glucuronate by enzymes bound to the endoplasmic reticulum membrane. It can be biosynthesized in many plants and bacteria and used as vitamin supplements. Other common uses include being an additive for beverage production and live stock feed. Without sufficient levels of L-ascorbate disorders such as scurvy may develop.
References
Ascorbate Biosynthesis References
Tulsiani DR, Touster: Resolution and partial characterization of two aldehyde reductases of mammalian liver. J Biol Chem. 1977 Apr 25;252(8):2545-50.
Pubmed: 15991
Linster CL, Van Schaftingen E: Vitamin C. Biosynthesis, recycling and degradation in mammals. FEBS J. 2007 Jan;274(1):1-22. doi: 10.1111/j.1742-4658.2006.05607.x.
Pubmed: 17222174
Gallagher PM, D'Amore MA, Lund SD, Elliott RW, Pazik J, Hohman C, Korfhagen TR, Ganschow RE: DNA sequence variation within the beta-glucuronidase gene complex among inbred strains of mice. Genomics. 1987 Oct;1(2):145-52.
Pubmed: 2891607
Gallagher PM, D'Amore MA, Lund SD, Ganschow RE: The complete nucleotide sequence of murine beta-glucuronidase mRNA and its deduced polypeptide. Genomics. 1988 Apr;2(3):215-9.
Pubmed: 3397060
D'Amore MA, Gallagher PM, Korfhagen TR, Ganschow RE: Complete sequence and organization of the murine beta-glucuronidase gene. Biochemistry. 1988 Sep 6;27(18):7131-40. doi: 10.1021/bi00418a070.
Pubmed: 3196706
Allan D, Lohnes D: Cloning and developmental expression of mouse aldehyde reductase (AKR1A4). Mech Dev. 2000 Jun;94(1-2):271-5.
Pubmed: 10842086
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Pubmed: 16141072
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. doi: 10.1101/gr.2596504.
Pubmed: 15489334
Fujita T, Shirasawa T, Maruyama N: Isolation and characterization of genomic and cDNA clones encoding mouse senescence marker protein-30 (SMP30). Biochim Biophys Acta. 1996 Jul 31;1308(1):49-57. doi: 10.1016/0167-4781(96)00064-4.
Pubmed: 8765750
Murata T, Yamaguchi M: Molecular cloning of the cDNA coding for regucalcin and its mRNA expression in mouse liver: the expression is stimulated by calcium administration. Mol Cell Biochem. 1997 Aug;173(1-2):127-33. doi: 10.1023/a:1006887929369.
Pubmed: 9278263
Ha MN, Graham FL, D'Souza CK, Muller WJ, Igdoura SA, Schellhorn HE: Functional rescue of vitamin C synthesis deficiency in human cells using adenoviral-based expression of murine l-gulono-gamma-lactone oxidase. Genomics. 2004 Mar;83(3):482-92. doi: 10.1016/j.ygeno.2003.08.018.
Pubmed: 14962674
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