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Pathway Description
Riboflavin Metabolism
Bos taurus
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2018-08-10
Last Updated: 2019-09-12
Riboflavin (vitamin B2) is an important part of the enzyme cofactors FAD (flavin-adenine dinucleotide) and FMN (flavin mononucleotide). The name "riboflavin" actually comes from "ribose" and "flavin". Like the other B vitamins, riboflavin is needed for the breaking down and processing of ketone bodies, lipids, carbohydrates, and proteins. Riboflavin is found in many different foods, such as meats and vegetables.As the digestion process occurs, many different flavoproteins that come from food are broken down and riboflavin is reabsorbed. The reverse reaction is mediated by acid phosphatase 6. FMN can be turned into to FAD via FAD synthetase, while the reverse reaction is mediated by nucleotide pyrophosphatase. FAD and FMN are essential hydrogen carriers and are involved in over 100 redox reactions that take part in energy metabolism.
References
Riboflavin Metabolism References
Schmutz SM, Berryere TG, Ciobanu DC, Mileham AJ, Schmidtz BH, Fredholm M: A form of albinism in cattle is caused by a tyrosinase frameshift mutation. Mamm Genome. 2004 Jan;15(1):62-7. doi: 10.1007/s00335-002-2249-5.
Pubmed: 14727143
Culp JS, Blytt HJ, Hermodson M, Butler LG: Amino acid sequence of the active site peptide of bovine intestinal 5'-nucleotide phosphodiesterase and identification of the active site residue as threonine. J Biol Chem. 1985 Jul 15;260(14):8320-4.
Pubmed: 2989287
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL: A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24.
Pubmed: 19393038
Wo YY, Zhou MM, Stevis P, Davis JP, Zhang ZY, Van Etten RL: Cloning, expression, and catalytic mechanism of the low molecular weight phosphotyrosyl protein phosphatase from bovine heart. Biochemistry. 1992 Feb 18;31(6):1712-21. doi: 10.1021/bi00121a019.
Pubmed: 1339287
Camici G, Manao G, Cappugi G, Modesti A, Stefani M, Ramponi G: The complete amino acid sequence of the low molecular weight cytosolic acid phosphatase. J Biol Chem. 1989 Feb 15;264(5):2560-7.
Pubmed: 2644264
Cirri P, Chiarugi P, Camici G, Manao G, Raugei G, Cappugi G, Ramponi G: The role of Cys12, Cys17 and Arg18 in the catalytic mechanism of low-M(r) cytosolic phosphotyrosine protein phosphatase. Eur J Biochem. 1993 Jun 15;214(3):647-57. doi: 10.1111/j.1432-1033.1993.tb17965.x.
Pubmed: 8319676
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000070
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