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Dihydrodiol dehydrogenase 3 Dihydrodiol dehydrogenase 3 Cytochrome P450 11B1, mitochondrial Cytochrome P450 11B1, mitochondrial Dihydrodiol dehydrogenase 3 Hydroxysteroid 11-beta- dehydrogenase 1-like protein Dihydrodiol dehydrogenase 3 Steroid 21-hydroxylase Steroid 17-alpha- hydroxylase/17,20 lyase Steroid 21-hydroxylase Cytochrome P450 11B1, mitochondrial 3-beta-HSD 1 Steroid 21-hydroxylase 3-beta-HSD 1 Cytochrome P450 11B1, mitochondrial Steroid 21-hydroxylase Cytochrome P450 11B1, mitochondrial Cytochrome P450 11B1, mitochondrial Steroid 17-alpha- hydroxylase/17,20 lyase Steroid 21-hydroxylase 3-beta-HSD 1 3-beta-HSD 1 Steroid 17-alpha- hydroxylase/17,20 lyase Steroid 21-hydroxylase Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Steroid 17-alpha- hydroxylase/17,20 lyase Dihydrodiol dehydrogenase 3 Dihydrodiol dehydrogenase 3 Dihydrodiol dehydrogenase 3 Dihydrodiol dehydrogenase 3 Cytochrome P450 11B1, mitochondrial Dihydrodiol dehydrogenase 3 Dihydrodiol dehydrogenase 3 Corticosteroid 11-beta- dehydrogenase isozyme 2 Corticosteroid 11-beta- dehydrogenase isozyme 2 3 beta-hydroxy- delta 5-C27-steroid oxidoreductase Cholesterol Progesterone Progesterone 11b,21-Dihydroxy-3,20-oxo- 5b-pregnan-18-al NADPH 3a,11b,21-Trihydroxy-20-oxo- 5b-pregnan-18-al NADP NADP Aldosterone NADPH 18-Hydroxycorticosterone O2 H2O Corticosterone O2 H2O 11b,21-Dihydroxy-5b- pregnane-3,20-dione Tetrahydrocorticosterone NADP NADPH 11-Dehydrocorticosterone 21-Hydroxy-5b-pregnane- 3,11,20-trione NADP 3a,21-Dihydroxy-5b-pregnane- 11,20-dione NADPH NADP NADPH 11b-Hydroxyprogesterone 21-Deoxycortisol Cortisol Deoxycorticosterone 21-Hydroxypregnenolone NAD NADH Pregnenolone NAD NADH 17-Hydroxyprogesterone Cortexolone 17a-Hydroxypregnenolone NAD NADH NADH 17α,21-Dihydroxypregnenolone NAD 20a,22b-Dihydroxycholesterol 4- Methylpentanal 17a,20a-Dihydroxycholesterol 22b-Hydroxycholesterol 20α-Hydroxycholesterol 17a,21-Dihydroxy-5b- pregnane-3,11,20-trione NADP Cortisone NADPH Tetrahydrocortisone NADP NADPH Dihydrocortisol NADP NADPH Tetrahydrocortisol NADP NADPH O2 11b,17a,21-Trihydroxypreg- nenolone H2O NADPH 5a-Pregnane-3,20-dione NADP 3a-Hydroxy-5b-pregnane-20-one NADP NADPH NADP NADPH Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Steroid Biosynthesis Adrenal Gland Smooth Endoplasmic Reticulum Smooth Endoplasmic Reticulum ER Membrane ER Membrane ER Membrane Mitochondrion Mitochondrion Mitochondrion Mitochondrion Intracellular Space Extracellular Space Inner mitochondria membrane Outer mitochondria membrane
Endoplasmic Reticulum Mitochondria Endoplasmic Reticulum Unknown Unknown CYP11B1 CYP11B1 Unknown HSD11B1L Unknown CYP21 CYP17A1 CYP21 CYP11B1 HSD3B7 CYP21 HSD3B7 CYP11B1 CYP21 CYP11B1 CYP11B1 CYP17A1 CYP21 HSD3B7 HSD3B7 CYP17A1 CYP21 CYP11A1 CYP11A1 CYP11A1 CYP11A1 CYP11A1 CYP11A1 CYP17A1 Unknown Unknown Unknown Unknown CYP11B1 Unknown Unknown HSD11B2 HSD11B2 HSD3B7 Cholesterol Progesterone Progesterone 11b,21- Dihydroxy- 3,20-oxo-5b- pregnan-18-al NADPH 3a,11b,21- Trihydroxy- 20-oxo-5b- pregnan-18-al NADP NADP Aldosterone NADPH 18- Hydroxycorticosterone Oxygen Water Corticosterone Oxygen Water 11b,21- Dihydroxy-5b- pregnane- 3,20-dione Tetrahydrocorticosterone NADP NADPH 11- Dehydrocorticosterone 21-Hydroxy- 5b-pregnane- 3,11,20- trione NADP 3a,21- Dihydroxy-5b- pregnane- 11,20-dione NADPH NADP NADPH 11b- Hydroxyprogesterone 21- Deoxycortisol Cortisol Deoxycorticosterone 21- Hydroxypregnenolone NAD NADH Pregnenolone NAD NADH 17- Hydroxyprogesterone Cortexolone 17a- Hydroxypregnenolone NAD NADH NADH 17α,21- Dihydroxypregnenolone NAD 20a,22b- Dihydroxycholesterol 4- Methylpentanal 17a,20a- Dihydroxycholesterol 22b- Hydroxycholesterol 20α- Hydroxycholesterol 17a,21- Dihydroxy-5b- pregnane- 3,11,20- trione NADP Cortisone NADPH Tetrahydrocortisone NADP NADPH Dihydrocortisol NADP NADPH Tetrahydrocortisol NADP NADPH Oxygen 11b,17a,21- Trihydroxypreg- nenolone Water NADPH 5a-Pregnane- 3,20-dione NADP 3a-Hydroxy- 5b-pregnane- 20-one NADP NADPH NADP NADPH Steroid Biosynthesis
CYP11B1 CYP11B1 HSD11B1L CYP21 CYP17A1 CYP21 CYP11B1 HSD3B7 CYP21 HSD3B7 CYP11B1 CYP21 CYP11B1 CYP11B1 CYP17A1 CYP21 HSD3B7 HSD3B7 CYP17A1 CYP21 CYP11A1 CYP11A1 CYP11A1 CYP11A1 CYP11A1 CYP11A1 CYP17A1 CYP11B1 HSD11B2 HSD11B2 HSD3B7 Lanol Prgstrn Prgstrn NA NADPH T20OPal NADP NADP Aldostr NADPH 18-HCC O2 H2O Cortcos O2 H2O 11B21D5 Tetrahy NADP NADPH 11dhccn 21-Hydr NADP 321D5B NADPH NADP NADPH 11Hprgt 21HOCrt HC Doct 21-Hpgn NAD NADH Pregnen NAD NADH 17-OHP Cortexo 17a-HP NAD NADH NADH 17ADhp NAD OH2chol 4-MPnal 17aDhch 22b-HC 20a-HC DHPRGT NADP Corlin NADPH TetraHC NADP NADPH DHCort NADP NADPH tetHCol NADP NADPH O2 Trihpnn H2O NADPH P3D NADP 3aH5bPO NADP NADPH NADP NADPH Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme PW000050 Adrenal Gland Smooth Endoplasmic Reticulum Smooth Endoplasmic Reticulum ER Membrane ER Membrane ER Membrane Mitochondrion Mitochondrion Mitochondrion Mitochondrion Intracellular Space Extracellular Space Inner mitochondria membrane Outer mitochondria membrane
Endoplasmic Reticulum Mitochondria Endoplasmic Reticulum CYP11B1 CYP11B1 HSD11B1L CYP21 CYP17A1 CYP21 CYP11B1 HSD3B7 CYP21 HSD3B7 CYP11B1 CYP21 CYP11B1 CYP11B1 CYP17A1 CYP21 HSD3B7 HSD3B7 CYP17A1 CYP21 CYP11A1 CYP11A1 CYP11A1 CYP11A1 CYP11A1 CYP11A1 CYP17A1 CYP11B1 HSD11B2 HSD11B2 HSD3B7 Lanol Prgstrn Prgstrn NA NADPH T20OPal NADP NADP Aldostr NADPH 18-HCC O2 H2O Cortcos O2 H2O 11B21D5 Tetrahy NADP NADPH 11dhccn 21-Hydr NADP 321D5B NADPH NADP NADPH 11Hprgt 21HOCrt HC Doct 21-Hpgn NAD NADH Pregnen NAD NADH 17-OHP Cortexo 17a-HP NAD NADH NADH 17ADhp NAD OH2chol 4-MPnal 17aDhch 22b-HC 20a-HC DHPRGT NADP Corlin NADPH TetraHC NADP NADPH DHCort NADP NADPH tetHCol NADP NADPH O2 Trihpnn H2O NADPH P3D NADP 3aH5bPO NADP NADPH NADP NADPH PW000050