PathBank

Pathway Description

Vasopressin Regulation of Water Homeostasis

Bos taurus

Category:

Protein Pathway

Sub-Categories:

Protein/Peptide Hormone-Mediated

Kinase Signaling

Disease

Cellular Response

Created: 2018-08-31

Last Updated: 2019-10-22

The vasopressin V2 receptor is found in the kidneys. It serves a role in maintaining corporal water homeostasis. Malfunction of this receptor can lead to Nephrogenic Diabetes Insipidus. Vasopressin (aka Antidiuretic hormone) activates both follicle-stimulating hormone receptor as well as the V2 receptor G protein complex. From this complex, Guanine nucleotide binding protein G(s) protein reacts with Adenylate Cyclase Type 2, Adeonsine Triphosphate, as well as GTP and magnesium to produce cAMP and Pyrophosphate. cAMP then activates PKA (protein kinase A) which leads to changes in the concentration of water in urine.

References

Vasopressin Regulation of Water Homeostasis References

Ufer E, Postina R, Gorbulev V, Fahrenholz F: An extracellular residue determines the agonist specificity of V2 vasopressin receptors. FEBS Lett. 1995 Mar 27;362(1):19-23. doi: 10.1016/0014-5793(95)00150-8.

Pubmed: 7698346

Kojro E, Eich P, Gimpl G, Fahrenholz F: Direct identification of an extracellular agonist binding site in the renal V2 vasopressin receptor. Biochemistry. 1993 Dec 14;32(49):13537-44. doi: 10.1021/bi00212a020.

Pubmed: 8257689

Morishita R, Nakayama H, Isobe T, Matsuda T, Hashimoto Y, Okano T, Fukada Y, Mizuno K, Ohno S, Kozawa O, et al.: Primary structure of a gamma subunit of G protein, gamma 12, and its phosphorylation by protein kinase C. J Biol Chem. 1995 Dec 8;270(49):29469-75. doi: 10.1074/jbc.270.49.29469.

Pubmed: 7493986

Nukada T, Tanabe T, Takahashi H, Noda M, Hirose T, Inayama S, Numa S: Primary structure of the alpha-subunit of bovine adenylate cyclase-stimulating G-protein deduced from the cDNA sequence. FEBS Lett. 1986 Jan 20;195(1-2):220-4. doi: 10.1016/0014-5793(86)80164-8.

Pubmed: 3080331

Robishaw JD, Russell DW, Harris BA, Smigel MD, Gilman AG: Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1251-5. doi: 10.1073/pnas.83.5.1251.

Pubmed: 3081893

Robishaw JD, Smigel MD, Gilman AG: Molecular basis for two forms of the G protein that stimulates adenylate cyclase. J Biol Chem. 1986 Jul 25;261(21):9587-90.

Pubmed: 3015900

Fong HK, Hurley JB, Hopkins RS, Miake-Lye R, Johnson MS, Doolittle RF, Simon MI: Repetitive segmental structure of the transducin beta subunit: homology with the CDC4 gene and identification of related mRNAs. Proc Natl Acad Sci U S A. 1986 Apr;83(7):2162-6. doi: 10.1073/pnas.83.7.2162.

Pubmed: 3083416

Sugimoto K, Nukada T, Tanabe T, Takahashi H, Noda M, Minamino N, Kangawa K, Matsuo H, Hirose T, Inayama S, et al.: Primary structure of the beta-subunit of bovine transducin deduced from the cDNA sequence. FEBS Lett. 1985 Oct 28;191(2):235-40. doi: 10.1016/0014-5793(85)80015-6.

Pubmed: 2414128

Cuello F, Schulze RA, Heemeyer F, Meyer HE, Lutz S, Jakobs KH, Niroomand F, Wieland T: Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. J Biol Chem. 2003 Feb 28;278(9):7220-6. doi: 10.1074/jbc.M210304200. Epub 2002 Dec 16.

Pubmed: 12486123

Volkel H, Beitz E, Klumpp S, Schultz JE: Cloning and expression of a bovine adenylyl cyclase type VII specific to the retinal pigment epithelium. FEBS Lett. 1996 Jan 15;378(3):245-9. doi: 10.1016/0014-5793(95)01470-5.

Pubmed: 8557110

Showers MO, Maurer RA: A cloned bovine cDNA encodes an alternate form of the catalytic subunit of cAMP-dependent protein kinase. J Biol Chem. 1986 Dec 15;261(35):16288-91.

Pubmed: 3023347

Wiemann S, Kinzel V, Pyerin W: Isoform C beta 2, an unusual form of the bovine catalytic subunit of cAMP-dependent protein kinase. J Biol Chem. 1991 Mar 15;266(8):5140-6.

Pubmed: 2002051

Jedrzejewski PT, Girod A, Tholey A, Konig N, Thullner S, Kinzel V, Bossemeyer D: A conserved deamidation site at Asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry. Protein Sci. 1998 Feb;7(2):457-69. doi: 10.1002/pro.5560070227.

Pubmed: 9521123

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0000322

	Adenosine triphosphate
	cAMP
	Guanosine diphosphate
	Guanosine triphosphate
	Magnesium
	Pyrophosphate
	Vasopressin

	Adenylate cyclase type 7
	cAMP-dependent protein kinase catalytic subunit beta
	Follicle-stimulating hormone receptor
	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
	Vasopressin V2 receptor

		Adenosine triphosphate
		cAMP
		Guanosine diphosphate
		Guanosine triphosphate
		Magnesium
		Pyrophosphate
		Vasopressin

		Adenylate cyclase type 7
		cAMP-dependent protein kinase catalytic subunit beta
		Follicle-stimulating hormone receptor
		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
		Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
		Vasopressin V2 receptor

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Vasopressin Regulation of Water Homeostasis

Vasopressin Regulation of Water Homeostasis References