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Pathway Description
Activation of cAMP-dependent protein kinase, PKA
Bos taurus
Category:
Protein Pathway
Sub-Categories:
Protein/Peptide Hormone-Mediated
Kinase Signaling
Cellular Response
Created: 2018-08-31
Last Updated: 2019-09-15
cAMP dependent protein kinase is a signalling molecule, found in the nucleus and cytoplasm of cells. Cellular regulation and signal transduction in eukaryotic cells is driven by the phosphorylation of proteins. cAMP dependent protein kinase is created as an active enzyme, which is made possible by a fully phosphorylated activation loop.
References
Activation of cAMP-dependent protein kinase, PKA References
Nukada T, Tanabe T, Takahashi H, Noda M, Hirose T, Inayama S, Numa S: Primary structure of the alpha-subunit of bovine adenylate cyclase-stimulating G-protein deduced from the cDNA sequence. FEBS Lett. 1986 Jan 20;195(1-2):220-4. doi: 10.1016/0014-5793(86)80164-8.
Pubmed: 3080331
Robishaw JD, Russell DW, Harris BA, Smigel MD, Gilman AG: Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1251-5. doi: 10.1073/pnas.83.5.1251.
Pubmed: 3081893
Robishaw JD, Smigel MD, Gilman AG: Molecular basis for two forms of the G protein that stimulates adenylate cyclase. J Biol Chem. 1986 Jul 25;261(21):9587-90.
Pubmed: 3015900
Hurley JB, Fong HK, Teplow DB, Dreyer WJ, Simon MI: Isolation and characterization of a cDNA clone for the gamma subunit of bovine retinal transducin. Proc Natl Acad Sci U S A. 1984 Nov;81(22):6948-52. doi: 10.1073/pnas.81.22.6948.
Pubmed: 6438626
Yatsunami K, Pandya BV, Oprian DD, Khorana HG: cDNA-derived amino acid sequence of the gamma subunit of GTPase from bovine rod outer segments. Proc Natl Acad Sci U S A. 1985 Apr;82(7):1936-40. doi: 10.1073/pnas.82.7.1936.
Pubmed: 2984674
Tao L, Pandey S, Simon MI, Fong HK: Structure of the bovine transducin gamma subunit gene and analysis of promoter function in transgenic mice. Exp Eye Res. 1993 Apr;56(4):497-507. doi: 10.1006/exer.1993.1063.
Pubmed: 8500562
Fong HK, Hurley JB, Hopkins RS, Miake-Lye R, Johnson MS, Doolittle RF, Simon MI: Repetitive segmental structure of the transducin beta subunit: homology with the CDC4 gene and identification of related mRNAs. Proc Natl Acad Sci U S A. 1986 Apr;83(7):2162-6. doi: 10.1073/pnas.83.7.2162.
Pubmed: 3083416
Sugimoto K, Nukada T, Tanabe T, Takahashi H, Noda M, Minamino N, Kangawa K, Matsuo H, Hirose T, Inayama S, et al.: Primary structure of the beta-subunit of bovine transducin deduced from the cDNA sequence. FEBS Lett. 1985 Oct 28;191(2):235-40. doi: 10.1016/0014-5793(85)80015-6.
Pubmed: 2414128
Cuello F, Schulze RA, Heemeyer F, Meyer HE, Lutz S, Jakobs KH, Niroomand F, Wieland T: Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. J Biol Chem. 2003 Feb 28;278(9):7220-6. doi: 10.1074/jbc.M210304200. Epub 2002 Dec 16.
Pubmed: 12486123
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL: A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24.
Pubmed: 19393038
Wiemann S, Kinzel V, Pyerin W: Cloning of the C alpha catalytic subunit of the bovine cAMP-dependent protein kinase. Biochim Biophys Acta. 1992 Nov 15;1171(1):93-6. doi: 10.1016/0167-4781(92)90144-o.
Pubmed: 1420367
Shoji S, Parmelee DC, Wade RD, Kumar S, Ericsson LH, Walsh KA, Neurath H, Long GL, Demaille JG, Fischer EH, Titani K: Complete amino acid sequence of the catalytic subunit of bovine cardiac muscle cyclic AMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1981 Feb;78(2):848-51. doi: 10.1073/pnas.78.2.848.
Pubmed: 6262777
Shoji S, Ericsson LH, Walsh KA, Fischer EH, Titani K: Amino acid sequence of the catalytic subunit of bovine type II adenosine cyclic 3',5'-phosphate dependent protein kinase. Biochemistry. 1983 Jul 19;22(15):3702-9. doi: 10.1021/bi00284a025.
Pubmed: 6311252
Showers MO, Maurer RA: A cloned bovine cDNA encodes an alternate form of the catalytic subunit of cAMP-dependent protein kinase. J Biol Chem. 1986 Dec 15;261(35):16288-91.
Pubmed: 3023347
Wiemann S, Kinzel V, Pyerin W: Isoform C beta 2, an unusual form of the bovine catalytic subunit of cAMP-dependent protein kinase. J Biol Chem. 1991 Mar 15;266(8):5140-6.
Pubmed: 2002051
Jedrzejewski PT, Girod A, Tholey A, Konig N, Thullner S, Kinzel V, Bossemeyer D: A conserved deamidation site at Asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry. Protein Sci. 1998 Feb;7(2):457-69. doi: 10.1002/pro.5560070227.
Pubmed: 9521123
Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling WM, Wiedmann RT, Van Tassell CP, Smith TP: Characterization of 954 bovine full-CDS cDNA sequences. BMC Genomics. 2005 Nov 23;6:166. doi: 10.1186/1471-2164-6-166.
Pubmed: 16305752
Titani K, Sasagawa T, Ericsson LH, Kumar S, Smith SB, Krebs EG, Walsh KA: Amino acid sequence of the regulatory subunit of bovine type I adenosine cyclic 3',5'-phosphate dependent protein kinase. Biochemistry. 1984 Aug 28;23(18):4193-9. doi: 10.1021/bi00313a028.
Pubmed: 6487597
Lee DC, Carmichael DF, Krebs EG, McKnight GS: Isolation of a cDNA clone for the type I regulatory subunit of bovine cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1983 Jun;80(12):3608-12. doi: 10.1073/pnas.80.12.3608.
Pubmed: 6190178
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0063764
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