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Pathway Description
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Rattus norvegicus
Category:
Protein Pathway
Sub-Categories:
Kinase Signaling
Neurological Signaling
Gene Regulatory
Cellular Response
Created: 2018-08-31
Last Updated: 2019-09-13
A member of the G-coupled protein receptor family, the adenosine A2A receptor regulates blood flow to myocardial tissues through the action of vasodilating the coronary arteries, which can potentially lead to hypotension. The adenosine receptor A2a activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream effectors that lead to a specific cellular response. This occurs through activation of the MAPK/ERK signaling cascade. The A2A receptor has also been demonstrated to play a role in dopamine and glutamate release in the CNS.
References
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine References
Chern Y, King K, Lai HL, Lai HT: Molecular cloning of a novel adenosine receptor gene from rat brain. Biochem Biophys Res Commun. 1992 May 29;185(1):304-9. doi: 10.1016/s0006-291x(05)90000-4.
Pubmed: 1599465
Fink JS, Weaver DR, Rivkees SA, Peterfreund RA, Pollack AE, Adler EM, Reppert SM: Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum. Brain Res Mol Brain Res. 1992 Jul;14(3):186-95. doi: 10.1016/0169-328x(92)90173-9.
Pubmed: 1279342
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Pubmed: 15489334
Watson JB, Coulter PM 2nd, Margulies JE, de Lecea L, Danielson PE, Erlander MG, Sutcliffe JG: G-protein gamma 7 subunit is selectively expressed in medium-sized neurons and dendrites of the rat neostriatum. J Neurosci Res. 1994 Sep 1;39(1):108-16. doi: 10.1002/jnr.490390113.
Pubmed: 7807587
Wang XB, Funada M, Imai Y, Revay RS, Ujike H, Vandenbergh DJ, Uhl GR: rGbeta1: a psychostimulant-regulated gene essential for establishing cocaine sensitization. J Neurosci. 1997 Aug 1;17(15):5993-6000.
Pubmed: 9221795
Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871.
Pubmed: 22673903
Itoh H, Kozasa T, Nagata S, Nakamura S, Katada T, Ui M, Iwai S, Ohtsuka E, Kawasaki H, Suzuki K, et al.: Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. Proc Natl Acad Sci U S A. 1986 Jun;83(11):3776-80. doi: 10.1073/pnas.83.11.3776.
Pubmed: 3086867
Jones DT, Reed RR: Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. J Biol Chem. 1987 Oct 15;262(29):14241-9.
Pubmed: 2820999
Crawford JA, Mutchler KJ, Sullivan BE, Lanigan TM, Clark MS, Russo AF: Neural expression of a novel alternatively spliced and polyadenylated Gs alpha transcript. J Biol Chem. 1993 May 5;268(13):9879-85.
Pubmed: 8486667
Feinstein PG, Schrader KA, Bakalyar HA, Tang WJ, Krupinski J, Gilman AG, Reed RR: Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10173-7. doi: 10.1073/pnas.88.22.10173.
Pubmed: 1719547
Chen J, DeVivo M, Dingus J, Harry A, Li J, Sui J, Carty DJ, Blank JL, Exton JH, Stoffel RH, et al.: A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits. Science. 1995 May 26;268(5214):1166-9. doi: 10.1126/science.7761832.
Pubmed: 7761832
Boran AD, Chen Y, Iyengar R: Identification of new Gbetagamma interaction sites in adenylyl cyclase 2. Cell Signal. 2011 Sep;23(9):1489-95. doi: 10.1016/j.cellsig.2011.05.002. Epub 2011 May 8.
Pubmed: 21596131
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000320
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