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Pathway Description
Vasopressin Regulation of Water Homeostasis
Rattus norvegicus
Category:
Protein Pathway
Sub-Categories:
Protein/Peptide Hormone-Mediated
Kinase Signaling
Disease
Cellular Response
Created: 2018-08-31
Last Updated: 2019-09-13
The vasopressin V2 receptor is found in the kidneys. It serves a role in maintaining corporal water homeostasis. Malfunction of this receptor can lead to Nephrogenic Diabetes Insipidus.
Vasopressin (aka Antidiuretic hormone) activates both follicle-stimulating hormone receptor as well as the V2 receptor G protein complex. From this complex, Guanine nucleotide binding protein G(s) protein reacts with Adenylate Cyclase Type 2, Adeonsine Triphosphate, as well as GTP and magnesium to produce cAMP and Pyrophosphate. cAMP then activates PKA (protein kinase A) which leads to changes in the concentration of water in urine.
References
Vasopressin Regulation of Water Homeostasis References
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Pubmed: 1534150
Firsov D, Mandon B, Morel A, Merot J, Le Maout S, Bellanger AC, de Rouffignac C, Elalouf JM, Buhler JM: Molecular analysis of vasopressin receptors in the rat nephron. Evidence for alternative splicing of the V2 receptor. Pflugers Arch. 1994 Nov;429(1):79-89. doi: 10.1007/bf02584033.
Pubmed: 7708485
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Pubmed: 7807587
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Pubmed: 3086867
Jones DT, Reed RR: Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. J Biol Chem. 1987 Oct 15;262(29):14241-9.
Pubmed: 2820999
Crawford JA, Mutchler KJ, Sullivan BE, Lanigan TM, Clark MS, Russo AF: Neural expression of a novel alternatively spliced and polyadenylated Gs alpha transcript. J Biol Chem. 1993 May 5;268(13):9879-85.
Pubmed: 8486667
Wang XB, Funada M, Imai Y, Revay RS, Ujike H, Vandenbergh DJ, Uhl GR: rGbeta1: a psychostimulant-regulated gene essential for establishing cocaine sensitization. J Neurosci. 1997 Aug 1;17(15):5993-6000.
Pubmed: 9221795
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Pubmed: 15489334
Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871.
Pubmed: 22673903
Feinstein PG, Schrader KA, Bakalyar HA, Tang WJ, Krupinski J, Gilman AG, Reed RR: Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10173-7. doi: 10.1073/pnas.88.22.10173.
Pubmed: 1719547
Chen J, DeVivo M, Dingus J, Harry A, Li J, Sui J, Carty DJ, Blank JL, Exton JH, Stoffel RH, et al.: A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits. Science. 1995 May 26;268(5214):1166-9. doi: 10.1126/science.7761832.
Pubmed: 7761832
Boran AD, Chen Y, Iyengar R: Identification of new Gbetagamma interaction sites in adenylyl cyclase 2. Cell Signal. 2011 Sep;23(9):1489-95. doi: 10.1016/j.cellsig.2011.05.002. Epub 2011 May 8.
Pubmed: 21596131
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000322
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