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Pathway Description
Kidney Function
Bos taurus
Category:
Metabolite Pathway
Sub-Category:
Physiological
Created: 2018-09-10
Last Updated: 2019-08-16
Kidneys are regulatory organs involved in removing wastes from the blood, hormone production, nutrient reabsorption, and regulating electrolyte concentrations, acid-base balance, extracellular fluid volume, and blood pressure. The early proximal tubule is where glucose, amino acids, sodium, chlorine, phosphate, bicarbonate, and water are reabsorbed. Only water is reabsorbed in the thin descending loop of Henle, while sodium, chlorine and potassium are reabsorbed in the thick ascending loop of Henle. Sodium and chlorine are also reabsorbed in the early distal convoluted tubule. Finally, sodium and water are reabsorbed in the collecting tubules. Blood pressure is regulated by the hormones angiotensin II and aldosterone, which increases sodium chloride reabsorption. This results in an expansion of the extracellular fluid compartment, thus increasing blood pressure.
References
Kidney Function References
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL: A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24.
Pubmed: 19393038
Fuller CM, Awayda MS, Arrate MP, Bradford AL, Morris RG, Canessa CM, Rossier BC, Benos DJ: Cloning of a bovine renal epithelial Na+ channel subunit. Am J Physiol. 1995 Sep;269(3 Pt 1):C641-54. doi: 10.1152/ajpcell.1995.269.3.C641.
Pubmed: 7573394
Enuka Y, Hanukoglu I, Edelheit O, Vaknine H, Hanukoglu A: Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways. Histochem Cell Biol. 2012 Mar;137(3):339-53. doi: 10.1007/s00418-011-0904-1. Epub 2011 Dec 30.
Pubmed: 22207244
Nicholson B, McGivan JD: Induction of high affinity glutamate transport activity by amino acid deprivation in renal epithelial cells does not involve an increase in the amount of transporter protein. J Biol Chem. 1996 May 24;271(21):12159-64. doi: 10.1074/jbc.271.21.12159.
Pubmed: 8647808
Smith TP, Grosse WM, Freking BA, Roberts AJ, Stone RT, Casas E, Wray JE, White J, Cho J, Fahrenkrug SC, Bennett GL, Heaton MP, Laegreid WW, Rohrer GA, Chitko-McKown CG, Pertea G, Holt I, Karamycheva S, Liang F, Quackenbush J, Keele JW: Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Genome Res. 2001 Apr;11(4):626-30. doi: 10.1101/gr.170101.
Pubmed: 11282978
Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling WM, Wiedmann RT, Van Tassell CP, Smith TP: Characterization of 954 bovine full-CDS cDNA sequences. BMC Genomics. 2005 Nov 23;6:166. doi: 10.1186/1471-2164-6-166.
Pubmed: 16305752
Boado RJ, Li JY, Nagaya M, Zhang C, Pardridge WM: Selective expression of the large neutral amino acid transporter at the blood-brain barrier. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):12079-84. doi: 10.1073/pnas.96.21.12079.
Pubmed: 10518579
Sakata K, Shimada S, Yamashita T, Inoue K, Tohyama M: Cloning of a bovine orphan transporter and its short splicing variant. FEBS Lett. 1999 Jan 29;443(3):267-70. doi: 10.1016/s0014-5793(98)01733-5.
Pubmed: 10025945
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000483
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