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Tyrosine- protein kinase Fyn Tyrosine- protein kinase Tyrosine- protein kinase Fyn Proto-oncogene vav Linker for activation of T cells SHC- transforming protein 1 GRB2-related adapter protein Rap guanine nucleotide exchange factor 2 RAS guanyl- releasing protein 4 Ras-related protein Rap-1b RAF proto-oncogene serine/threonine- protein kinase Dual specificity mitogen- activated protein kinase kinase 6 Mitogen- activated protein kinase 1 Receptor-type tyrosine- protein phosphatase F Phosphatidylinositol 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform Ras-related C3 botulinum toxin substrate 1 Aurora kinase A Dual specificity mitogen- activated protein kinase kinase 6 Mitogen- activated protein kinase 13 Transcription factor AP-1 Proto-oncogene c-Fos ETS translocation variant 1 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase gamma-1 Polyubiquitin-C NF-kappaB transcription factor p65 subunit NF-kappa-B inhibitor zeta NF-kappa-B inhibitor zeta Calmodulin Calmodulin Calmodulin Serine/threonine- protein phosphatase 2B catalytic subunit alpha isoform Serine/threonine- protein phosphatase 2B catalytic subunit alpha isoform Serine/threonine- protein phosphatase 2B catalytic subunit alpha isoform NF-kappa-B inhibitor zeta NF-kappaB transcription factor p65 subunit NF-kappa-B inhibitor zeta Nuclear factor of activated T-cells, cytoplasmic 1 Nuclear factor of activated T-cells, cytoplasmic 1 Nuclear factor of activated T-cells, cytoplasmic 1 Nuclear factor of activated T-cells, cytoplasmic 1 Uncharacterized protein Uncharacterized protein CD247 molecule T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain Protein kinase C alpha type Protein kinase C beta type Nuclear factor of activated T-cells, cytoplasmic 1 Nuclear factor of activated T-cells, cytoplasmic 1 Nuclear factor of activated T-cells, cytoplasmic 1 Nuclear factor of activated T-cells, cytoplasmic 1 Diacylglycerol Ca+ Tacrolimus Cyclosporin A H2O Phosphatidylinositol 4,5- bisphosphate Inositol 1,4,5- trisphosphate Pi Phosphate Phosphate Phosphate Guanosine triphosphate Phosphate Phosphate Phosphate Calcium Phosphate Ca+ Pi Antigen IP3 triggers the release of Ca2+ from the ER Transcription factors increase gene expression by interacting with their regulatory sequences Cytoplasm Extracellular Space Nucleus Endoplasimc Reticulum
FYN SYK FYN VAV1 LAT SHC1 GRAP RAPGEF2 RASGRP4 RAP1B RAF1 MAP2K6 MAPK1 PTPRF PIK3CA PIK3R1 PIK3CA RAC1 AURKA MAP2K6 MAPK13 JUN FOS ETV1 PLCG1 UBC RELA NFKBIZ NFKBIZ CALM CALM CALM PPP3CA PPP3CA PPP3CA NFKBIZ RELA NFKBIZ NFATC1 NFATC1 NFATC1 NFATC1 Unknown Unknown CD247 CD3G CD3D CD3E PRKCA PRKCB NFATC1 NFATC1 NFATC1 NFATC1 Diacylglycerol Calcium Tacrolimus Cyclosporin A Water Phosphatidylinositol 4,5- bisphosphate Inositol 1,4,5- trisphosphate Phosphate Calcium Phosphate Antigen
FYN SYK FYN VAV1 LAT SHC1 GRAP RAPGEF2 RASGRP4 RAP1B RAF1 MAP2K6 MAPK1 PTPRF PIK3CA PIK3R1 PIK3CA RAC1 AURKA MAP2K6 MAPK13 JUN FOS ETV1 PLCG1 UBC RELA NFKBIZ NFKBIZ CALM CALM CALM PPP3CA PPP3CA PPP3CA NFKBIZ RELA NFKBIZ NFATC1 NFATC1 NFATC1 NFATC1 CD247 CD3G CD3D CD3E PRKCA PRKCB NFATC1 NFATC1 NFATC1 NFATC1 Diacylg Ca+ Tacroli CyCloA H2O P45P Inotp Pi Pi Pi Pi GTP Pi Pi Pi Ca2+ Pi Ca+ Pi Antigen IP3 triggers the release of Ca2+ from the ER Transcription factors increase gene expression by interacting with their regulatory sequences Cytoplasm Extracellular Space Nucleus Endoplasimc Reticulum
FYN SYK FYN VAV1 LAT SHC1 GRAP RAPGEF2 RASGRP4 RAP1B RAF1 MAP2K6 MAPK1 PTPRF PIK3CA PIK3R1 PIK3CA RAC1 AURKA MAP2K6 MAPK13 JUN FOS ETV1 PLCG1 UBC RELA NFKBIZ NFKBIZ CALM CALM CALM PPP3CA PPP3CA PPP3CA NFKBIZ RELA NFKBIZ NFATC1 NFATC1 NFATC1 NFATC1 CD247 CD3G CD3D CD3E PRKCA PRKCB NFATC1 NFATC1 NFATC1 NFATC1 Diacylg Ca2+ Tacroli CyCloA H2O P45P Inotp Pi Ca2+ Pi Antigen