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Pathway Description
BCR Signaling Pathway
Bos taurus
Category:
Protein Pathway
Sub-Categories:
Immunological
Gene Regulatory
Kinase Signaling
Cellular Response
Created: 2018-09-20
Last Updated: 2019-08-16
The BCR signalling pathway is a pathway that plays a vital role in the development and all other functions of B-cells, which means it is vital for the immune response. The BCR, also known as the B-cell receptor, is usually found on the outer membrane of B-cells. B-cells grab antigens from immune synapses, through a number of processes including cell spreading and receptor transport. After these have been performed, endocytosis and antigen-presentation occur. B-cells manipulate the dynamic of BCR-antigen bonds. They group and spread the antigen, increasing the relation with BCR, which creates sensitivity. The two main functions of the BCR pathway is to signal transduction, and the second is to prepare the antigen for processing by the helper T cells. Any defects in this pathway may lead to the patient being immunodeficient, or having B-cell malignancy.
References
BCR Signaling Pathway References
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Pubmed: 2831461
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Pubmed: 1689311
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Pubmed: 19390049
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Pubmed: 8202141
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Pubmed: 19393038
Edwards JC, Kapadia S: Regulation of the bovine kidney microsomal chloride channel p64 by p59fyn, a Src family tyrosine kinase. J Biol Chem. 2000 Oct 13;275(41):31826-32. doi: 10.1074/jbc.M005275200.
Pubmed: 10930415
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Pubmed: 7963570
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Pubmed: 8810000
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Pubmed: 9312079
Lin Q, Lo CG, Cerione RA, Yang W: The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation. J Biol Chem. 2002 Mar 22;277(12):10134-8. doi: 10.1074/jbc.M110329200. Epub 2002 Jan 17.
Pubmed: 11799118
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0069871
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