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Tryptophan
N-monooxygenase
1
Tryptophan
N-monooxygenase
2
Tryptophan
N-monooxygenase
1
Tryptophan
N-monooxygenase
2
Indoleacetaldoxime
dehydratase
Indoleacetaldoxime
dehydratase
Indoleacetaldoxime
dehydratase
Indoleacetaldoxime
dehydratase
Glutathione
S-transferase
F6
Glutathione
hydrolase 3
Gamma-glutamyl
peptidase 1
Gamma-glutamyl
peptidase 3
Unknown
Bifunctional
dihydrocamalexate
synthase/camalexin
synthase
Bifunctional
dihydrocamalexate
synthase/camalexin
synthase
L-Tryptophan
O
2
N-hydroxy-L-
tryptophan
H
2
O
H
+
O
2
H
2
O
N,N-
dihydroxy-L-
tryptophan
H
+
(E)-indol-3-
ylacetaldoxime
CO
2
H
2
O
(Z)-indol-3-
ylacetaldoxime
H
2
O
3-
Indoleacetonitrile
O
2
2-hydroxy-2-
(1H-indol-3-
yl)acetonitrile
H
2
O
Dehydro(indole-
3-
yl)acetonitrile
H
2
O
Glutathione
(glutathion-
S-yl)(1H-
indol-3-
yl)acetonitrile
H
2
O
L-Glutamic acid
(L-
cysteinylglycin-
S-yl)(1H-
indol-3-
yl)acetonitrile
H
2
O
Glycine
2-(cystein-S-
yl)-2-(1H-
indol-3-yl)-
acetonitrile
O
2
Hydrogen
cyanide
H
2
O
H
+
(R)-
dihydrocamalexate
O
2
H
+
Camalexin
CO
2
H
2
O
[Reduced
NADPH---
hemoprotein
reductase]
[Oxidized
NADPH---
hemoprotein
reductase]
[Reduced
NADPH---
hemoprotein
reductase]
[Oxidized
NADPH---
hemoprotein
reductase]
[Reduced
NADPH---
hemoprotein
reductase]
[Oxidized
NADPH---
hemoprotein
reductase]
[Reduced
NADPH---
hemoprotein
reductase]
[Reduced
NADPH---
hemoprotein
reductase]
[Oxidized
NADPH---
hemoprotein
reductase]
Tryptophan
Metabolism
Cytosol
CYP79B2
CYP79B3
CYP79B2
CYP79B3
CYP71A13
CYP71A13
CYP71A13
CYP71A13
GSTF6
GGT3
GGP1
GGP3
Unknown
CYP71B15
CYP71B15
L-Tryptophan
Oxygen
N-hydroxy-L-
tryptophan
Water
Hydrogen Ion
Oxygen
Water
N,N-
dihydroxy-L-
tryptophan
Hydrogen Ion
(E)-indol-3-
ylacetaldoxime
Carbon dioxide
Water
(Z)-indol-3-
ylacetaldoxime
Water
3-
Indoleacetonitrile
Oxygen
2-hydroxy-2-
(1H-indol-3-
yl)acetonitrile
Water
Dehydro(indole-
3-
yl)acetonitrile
Water
Glutathione
(glutathion-
S-yl)(1H-
indol-3-
yl)acetonitrile
Water
L-Glutamic acid
(L-
cysteinylglycin-
S-yl)(1H-
indol-3-
yl)acetonitrile
Water
Glycine
2-(cystein-S-
yl)-2-(1H-
indol-3-yl)-
acetonitrile
Oxygen
Hydrogen
cyanide
Water
Hydrogen Ion
(R)-
dihydrocamalexate
Oxygen
Hydrogen Ion
Camalexin
Carbon dioxide
Water
[Reduced
NADPH---
hemoprotein
reductase]
[Oxidized
NADPH---
hemoprotein
reductase]
[Reduced
NADPH---
hemoprotein
reductase]
[Oxidized
NADPH---
hemoprotein
reductase]
[Reduced
NADPH---
hemoprotein
reductase]
[Oxidized
NADPH---
hemoprotein
reductase]
[Reduced
NADPH---
hemoprotein
reductase]
[Reduced
NADPH---
hemoprotein
reductase]
[Oxidized
NADPH---
hemoprotein
reductase]
Tryptophan
Metabolism