PathBank

Pathway Description

Lysine Degradation I

Pseudomonas aeruginosa

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2019-08-12

Last Updated: 2025-09-12

Lysine is an essential amino acid used in protein synthesis. Lysine can be transported into the cell by probable cadaverine (also known as lysine antiporter). Once inside the cell, lysine is decarboxylated by lysine decarboxylase to cadaverine. Cadaverine can then exit the cell via the same type of transporter as lysine (probable cadaverine). Alternatively, lysine can be produced during lysine biosynthesis (from aspartic acid) inside the cell and used in the same pathway.

References

Lysine Degradation I References

Luthi E, Baur H, Gamper M, Brunner F, Villeval D, Mercenier A, Haas D: The arc operon for anaerobic arginine catabolism in Pseudomonas aeruginosa contains an additional gene, arcD, encoding a membrane protein. Gene. 1990 Mar 1;87(1):37-43. doi: 10.1016/0378-1119(90)90493-b.

Pubmed: 2158926

Verhoogt HJ, Smit H, Abee T, Gamper M, Driessen AJ, Haas D, Konings WN: arcD, the first gene of the arc operon for anaerobic arginine catabolism in Pseudomonas aeruginosa, encodes an arginine-ornithine exchanger. J Bacteriol. 1992 Mar;174(5):1568-73. doi: 10.1128/jb.174.5.1568-1573.1992.

Pubmed: 1311296

Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. doi: 10.1038/35023079.

Pubmed: 10984043

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0000795

Highlighted elements will appear in red.

Highlight Compounds

	Cadaverine
	Carbon dioxide
	Hydrogen Ion
	L-Lysine

Highlight Proteins

	Arginine/ornithine antiporter
	Beta-eliminating lyase family protein
	Biodegradative arginine decarboxylase

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