PathBank

Pathway Description

Acetate Metabolism

Pseudomonas aeruginosa

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2019-08-12

Last Updated: 2019-08-16

The acetate biosynthesis starts with acetyl-CoA reacting with phosphate through a phosphate acetyltransferase resulting in the release of a coenzyme A and an acetyl phosphate. The latter compound in turn reacts with ADP through an acetate kinase resulting in the release of an ATP and an acetate. The acetate reacts with ATP and coenzyme A through an acetyl-CoA synthase resulting in the release of a diphosphate, an AMP and an acetyl-CoA. Acetyl-CoA can be biosynthesized by acetoacetate reacting with an acetyl-CoA through an acetoacetyl-CoA transferase resulting in the release of an acetate and an acetoacetyl-CoA. The acetoacetyl-CoA reacts with an acetyl-CoA acetyltransferase resulting in the release of an coenzyme A and 2 acetyl-CoA

References

Acetate Metabolism References

Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. doi: 10.1038/35023079.

Pubmed: 10984043

Eschbach M, Schreiber K, Trunk K, Buer J, Jahn D, Schobert M: Long-term anaerobic survival of the opportunistic pathogen Pseudomonas aeruginosa via pyruvate fermentation. J Bacteriol. 2004 Jul;186(14):4596-604. doi: 10.1128/JB.186.14.4596-4604.2004.

Pubmed: 15231792

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0002102

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Acetic acid
		Acetoacetic acid
		Acetoacetyl-CoA
		Acetyl-CoA
		Acetylphosphate
		Adenosine diphosphate
		Adenosine monophosphate
		Adenosine triphosphate
		Coenzyme A
		Magnesium
		Phosphate
		Pyrophosphate

Visualize Protein Data

		Acetate kinase
		Acetyl-CoA acetyltransferase
		Acetyl-coenzyme A synthetase 1
		Phosphate acetyltransferase
		Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A
		Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B