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Pathway Description
Phenylalanine Metabolism
Drosophila melanogaster
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2020-06-09
Last Updated: 2023-10-28
Phenylalanine is reduced into different substrates like tyrosine, which can be further metabolized or substrates that feed into catabolic processes like the citric acid cycle and glycolysis. L-Phenylalanine is reduced to phenylethylamine via L-amino-acid decarboxylase releasing carbon dioxide. Phenylethylamine is further reduced into phenylacetaldehyde by monoamine oxidase on the hepatocyte plasma membrane to give phenylacetaldehyde. Phenylacetaldehyde can be metabolized further into phenylacetic acid through another hepatocyte membrane enzyme aldehyde dehydrogenase.
References
Phenylalanine Metabolism References
Kanehisa M, Goto S: KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000 Jan 1;28(1):27-30. doi: 10.1093/nar/28.1.27.
Pubmed: 10592173
Kanehisa M, Sato Y, Furumichi M, Morishima K, Tanabe M: New approach for understanding genome variations in KEGG. Nucleic Acids Res. 2019 Jan 8;47(D1):D590-D595. doi: 10.1093/nar/gky962.
Pubmed: 30321428
Kanehisa M: Toward understanding the origin and evolution of cellular organisms. Protein Sci. 2019 Nov;28(11):1947-1951. doi: 10.1002/pro.3715. Epub 2019 Sep 9.
Pubmed: 31441146
Neckameyer WS, White K: A single locus encodes both phenylalanine hydroxylase and tryptophan hydroxylase activities in Drosophila. J Biol Chem. 1992 Feb 25;267(6):4199-206.
Pubmed: 1371286
Morales G, Requena JM, Jimenez-Ruiz A, Lopez MC, Ugarte M, Alonso C: Sequence and expression of the Drosophila phenylalanine hydroxylase mRNA. Gene. 1990 Sep 14;93(2):213-9. doi: 10.1016/0378-1119(90)90227-i.
Pubmed: 2121612
Ruiz-Vazquez P, Moulard M, Silva FJ: Structure of the phenylalanine hydroxylase gene in Drosophila melanogaster and evidence of alternative promoter usage. Biochem Biophys Res Commun. 1996 Aug 5;225(1):238-42. doi: 10.1006/bbrc.1996.1160.
Pubmed: 8769124
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