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Pathway Description
Ifosfamide Alkylating Agent Action Pathway
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Drug Action
Created: 2021-05-06
Last Updated: 2023-10-25
Ifosfamide is an alkylating agent administered intravenously that is used in chemotherapy against various cancers. It works by crosslink DNA guanine residues. Ifosfamide is converted into 4-hydroxyifosfamide through various hepatic CYP450. 4-Hydroxyifosfmamide can be converted to its tautomer aldophosphamide or to an inactive form 4-ketoifosfamide. Aldophosphamide is taken into cancer/tumor cells where it is converted to its cytotoxic form isophosphamide mustard which crosslinks the DNA after being converted to it's carbocation form. In the process of isophosphamide mustard production, acrolein is produced which is a potent lung irritant and causes hemorrhagic cystitis. Side effects of ifosfamide is myelosuppression, immunosuppression and hemorrhagic cystitis (caused by acrolein).
References
Ifosfamide Alkylating Agent Pathway References
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