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Glucagon-like peptide 1 receptor Dipeptidyl peptidase 4 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase catalytic subunit gamma cAMP-dependent protein kinase type I-beta regulatory subunit cAMP-dependent protein kinase type II-beta regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit Rap guanine nucleotide exchange factor 4 ATP-binding cassette sub-family C member 8 Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Insulin Ryanodine receptor 2 Adenylate cyclase type 10 Solute carrier family 2, facilitated glucose transporter member 2 Insulin Glucagon-like peptide 1 Sitagliptin cAMP ATP K+ Ca+ Ca+ D-Glucose D-Glucose K+ Ca+ Ca+ GLP-1-(9-36) amide ATP PPi D-Glucose Magnesium Gs protein signaling Glycolysis Oxidative Phosphorylation (Homo Sapiens Sitagliptin inhibits DPP-4, preventing GLP-1 metabolism Beta Cell ↑ Increased glucose concentration ↑ Glucose concentration causes ↑ ATP synthesis ATP inhibits the ATP-sensitive K+ pump by causing a conformational change causing the potassium pore to close Reduced K+ efflux causes depolarozation of the membrane Depolarization ΔVm ↑ Influx of calcium ions causes an increase in Insulin secretion Reduced membrane potential activates voltage-gated Ca2+ channels Insulin secretion ↓ Glucose concentration decreases PKA activates voltage gated L-type calcium channels PKA inhibits ATP-sensitive potassium channels Rap guanine nucleotide exchange factor 4 activates the ryanodine receptor on the endoplasmic reticulum leading to calcium influx into he cytosol Cytosol Pancreas Islet Mitochondria Endoplasmic Reticulum
GLP1R DPP4 PRKACA PRKACB PRKAR1A PRKACG PRKAR1B PRKAR2B PRKAR2A RAPGEF4 ABCC8 CACNA1A CACNB1 CACNA2D2 Unknown RYR2 ADCY10 SLC2A2 Unknown Glucagon-like peptide 1 Sitagliptin cAMP Adenosine triphosphate Potassium Calcium Calcium D-Glucose D-Glucose Potassium Calcium Calcium GLP-1-(9-36) amide Adenosine triphosphate Pyrophosphate D-Glucose Gs protein signaling Glycolysis Oxidative Phosphorylation (Homo Sapiens
GLP1R DPP4 PRKACA PRKACB PRKAR1A PRKACG PRKAR1B PRKAR2B PRKAR2A RAPGEF4 ABCC8 CACNA1A CACNB1 CACNA2D2 RYR2 ADCY10 SLC2A2 GLP1 MK-0431 cAMP ATP K+ Ca+ Ca+ D-Glc D-Glc K+ Ca+ Ca+ G-1-9-3 ATP PPi D-Glc Mg2+ G p s PW000146 O P H S Sitagliptin inhibits DPP-4, preventing GLP-1 metabolism Beta Cell ↑ Increased glucose concentration ↑ Glucose concentration causes ↑ ATP synthesis ATP inhibits the ATP-sensitive K+ pump by causing a conformational change causing the potassium pore to close Reduced K+ efflux causes depolarozation of the membrane Depolarization ΔVm ↑ Influx of calcium ions causes an increase in Insulin secretion Reduced membrane potential activates voltage-gated Ca2+ channels Insulin secretion ↓ Glucose concentration decreases PKA activates voltage gated L-type calcium channels PKA inhibits ATP-sensitive potassium channels Rap guanine nucleotide exchange factor 4 activates the ryanodine receptor on the endoplasmic reticulum leading to calcium influx into he cytosol Cytosol Pancreas Islet Mitochondria Endoplasmic Reticulum
GLP1R DPP4 PRKACA PRKACB PRKAR1A PRKACG PRKAR1B PRKAR2B PRKAR2A RAPGEF4 ABCC8 CACNA1A CACNB1 CACNA2D2 RYR2 ADCY10 SLC2A2 GLP1 MK-0431 cAMP ATP K+ Ca2+ Ca2+ D-Glc D-Glc K+ Ca2+ Ca2+ G-1-9-3 ATP Ppi D-Glc G p s PW000146 O P H S