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Egl nine homolog 2 hypoxia- inducible factor-1α Succinate receptor 1 Guanine nucleotide- binding protein G(q) subunit alpha 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-1 Inositol 1,4,5- trisphosphate receptor type 1 Protein kinase C alpha type Prostaglandin G/H synthase 2 Prostaglandin G/H synthase 1 Nitric oxide synthase, endothelial Mitogen- activated protein kinase 1 Mitogen- activated protein kinase 3 Prostaglandin G/H synthase 2 Prostaglandin G/H synthase 1 Nuclear factor NF-kappa-B p105 subunit Toll-like receptor 4 Ubiquitinated hypoxia inducible factor 1 alpha Solute carrier family 2, facilitated glucose transporter member 2 Voltage- dependent anion-selective channel protein 2 Pyruvate carboxylase, mitochondrial Mitochondrial dicarboxylate carrier Voltage- dependent anion-selective channel protein 1 Succinate nuclear transporter Hydroxylated hypoxia- inducible factor 1-alpha Hydroxylated hypoxia- inducible factor 1-alpha Nuclear pore Solute carrier family 13 member 3 citrate synthase Aconitate hydratase, mitochondrial Aconitate hydratase, mitochondrial Malate dehydrogenase, mitochondrial Fumarate hydratase, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Dihydrolipoyllysine- residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Dihydrolipoyl dehydrogenase, mitochondrial Succinyl-CoA ligase [ADP/GDP- forming] subunit alpha, mitochondrial Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial Dihydrolipoyllysine- residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial Dihydrolipoyl dehydrogenase, mitochondrial Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Von Hippel-Lindau disease tumor suppressor Cytosolic phospholipase A2 Prostaglandin E synthase Succinic acid Succinic acid Inositol 1,4,5- trisphosphate Ca+ Lipopolysaccharide D-Glucose pyruvate NO Prostaglandin E2 D-Glucose pyruvate pyruvate Succinic acid Succinic acid Succinic acid Ca+ Acetyl-CoA H2O Oxaloacetate Citrate CoA cis-Aconitic acid H2O H2O Isocitric acid Malate NAD NADH H+ Fumaric acid H2O CoA NADP CO2 NADPH ATP CoA Succinyl-CoA ADP Pi Oxoglutaric acid NAD CoA NADH H+ CO2 NAD CO2 NADH H+ Hydroquinone Quinone Phosphatidylinositol 4,5- bisphosphate Arachidonic acid Prostaglandin H2 O2 Prostaglandin G2 H2O H+ L-Arginine NADPH O2 H2O L-Citrulline NADP Ascorbic acid Calcium Heme Heme Heme Heme Heme Biotin Manganese 4Fe-4S 4Fe-4S Thiamine pyrophosphate Lipoamide Magnesium FAD 2Fe-2S Calcium Glutathione Diacylglycerol Reactive oxygen species Phospholipids Acceptor Reduced acceptor IL-1β IL-1β Glycolysis Proteasomal degradation Inflammation TLR4 receptor signaling pathway FAD Flavin Mononucleotide Tetrahydrobiopterin FAD Thiamine pyrophosphate Lipoamide FAD Fe2+ Magnesium Magnesium Intermembrane space Outer membrane Inner membrane Mitochondria Macrophage Nucleus Outer membrane Inner membrane Intermembrane space Cytosol Dendritic Cell Pro-inflammatory cytokine TCA Cycle Nucleus Endoplasmic Reticulum Cytosol Pro-inflammatory cytokine PGE2 can also act as a chemotactic factor
Mitochondria Nucleus Endoplasmic Reticulum Nucleus EGLN2 HIF1A SUCNR1 GNAQ PLCB1 ITPR1 PRKCA PTGS2 PTGS1 NOS3 MAPK1 MAPK3 PTGS2 PTGS1 NFKB1 TLR4 HIF1A SLC2A2 VDAC2 PC SLC25A10 VDAC1 Unknown HIF1A HIF1A Unknown SLC13A3 CIT2 ACO2 ACO2 MDH2 FH PDHA1 PDHB DLAT DLD SUCLG1 SUCLG2 DHTKD1 DLST DLD IDH3A IDH3B IDH3G SDHA SDHB SDHC SDHD VHL PLA2G4A PTGES Succinic acid Succinic acid Inositol 1,4,5- trisphosphate Calcium Lipopolysaccharide D-Glucose pyruvate Nitric oxide Prostaglandin E2 D-Glucose pyruvate pyruvate Succinic acid Succinic acid Succinic acid Calcium Acetyl-CoA Water Oxaloacetate Citrate Coenzyme A cis-Aconitic acid Water Water Isocitric acid Malate NAD NADH Hydrogen Ion Fumaric acid Water Coenzyme A NADP Carbon dioxide NADPH Adenosine triphosphate Coenzyme A Succinyl-CoA Adenosine diphosphate Phosphate Oxoglutaric acid NAD Coenzyme A NADH Hydrogen Ion Carbon dioxide NAD Carbon dioxide NADH Hydrogen Ion Hydroquinone Quinone Phosphatidylinositol 4,5- bisphosphate Arachidonic acid Prostaglandin H2 Oxygen Prostaglandin G2 Water Hydrogen Ion L-Arginine NADPH Oxygen Water L-Citrulline NADP Diacylglycerol Reactive oxygen species Phospholipids Acceptor Reduced acceptor IL-1β IL-1β Glycolysis Proteasomal degradation Inflammation TLR4 receptor signaling pathway
EGLN2 HIF1A SUCNR1 GNAQ PLCB1 ITPR1 PRKCA PTGS2 PTGS1 NOS3 MAPK1 MAPK3 PTGS2 PTGS1 NFKB1 TLR4 HIF1A SLC2A2 VDAC2 PC SLC25A10 VDAC1 HIF1A HIF1A SLC13A3 CIT2 ACO2 ACO2 MDH2 FH PDHA1 PDHB DLAT DLD SUCLG1 SUCLG2 DHTKD1 DLST DLD IDH3A IDH3B IDH3G SDHA SDHB SDHC SDHD VHL PLA2G4A PTGES Succini Succini Inotp Ca+ Lipopol D-Glc pyruv NO PGE2 D-Glc pyruv pyruv Succini Succini Succini Ca+ Ac-CoA H2O Oxalo Citrate CoA Aconiti H2O H2O I-cita Malate NAD NADH H+ Fumarat H2O CoA NADP CO2 NADPH ATP CoA Suc-CoA ADP Pi AKG NAD CoA NADH H+ CO2 NAD CO2 NADH H+ Quinol Quinone P45P 20:4 PGH2 O2 PGG2 H2O H+ Arg NADPH O2 H2O LC NADP VitC Ca2+ Heme Heme Heme Heme Heme Biotin Mn2+ 4Fe-4S 4Fe-4S ThiamPP Lipoamd Mg2+ FAD 2Fe2S Ca2+ GSH Diacylg Re ox s Phosp Accepto RA IL-1β IL-1β PW000146 Pro deg PW123878 T r s p FAD FlvnMnt BH4 FAD ThiamPP Lipoamd FAD Fe2+ Mg2+ Mg2+ Intermembrane space Outer membrane Inner membrane Mitochondria Macrophage Nucleus Outer membrane Inner membrane Intermembrane space Cytosol Dendritic Cell Pro-inflammatory cytokine TCA Cycle Nucleus Endoplasmic Reticulum Cytosol Pro-inflammatory cytokine PGE2 can also act as a chemotactic factor
Mitochondria Nucleus Endoplasmic Reticulum Nucleus EGLN2 HIF1A SUCNR1 GNAQ PLCB1 ITPR1 PRKCA PTGS2 PTGS1 NOS3 MAPK1 MAPK3 PTGS2 PTGS1 NFKB1 TLR4 HIF1A SLC2A2 VDAC2 PC SLC25A10 VDAC1 HIF1A HIF1A SLC13A3 CIT2 ACO2 ACO2 MDH2 FH PDHA1 PDHB DLAT DLD SUCLG1 SUCLG2 DHTKD1 DLST DLD IDH3A IDH3B IDH3G SDHA SDHB SDHC SDHD VHL PLA2G4A PTGES Succini Succini Inotp Ca2+ Lipopol D-Glc pyruv NO PGE2 D-Glc pyruv pyruv Succini Succini Succini Ca2+ Ac-CoA H2O Oxalo Citrate CoA Aconiti H2O H2O I-cita Malate NAD NADH H+ Fumarat H2O CoA NADP CO2 NADPH ATP CoA Suc-CoA ADP Pi AKG NAD CoA NADH H+ CO2 NAD CO2 NADH H+ Quinol Quinone P45P 20:4 PGH2 O2 PGG2 H2O H+ Arg NADPH O2 H2O LC NADP Diacylg Re ox s Phosp Accepto RA IL-1β IL-1β PW000146 Pro deg PW123878 T r s p