Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loader

Loading Pathway...

Myosin light chain kinase, smooth muscle Inositol 1,4,5- trisphosphate receptor type 1 Alpha-1A adrenergic receptor Alpha-2A adrenergic receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Actin, cytoplasmic 1 Myosin LC-P Myosin light chain 3 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-1 Synaptic vesicular amine transporter Sodium- dependent noradrenaline transporter Calmodulin-1 Serine/threonine- protein phosphatase PP1-beta catalytic subunit Tyrosine 3-monooxygenase Aromatic-L- amino-acid decarboxylase Dopamine beta- hydroxylase Calmodulin-1 Inositol 1,4,5- trisphosphate Norepinephrine Ca+ Norepinephrine Ca+ Ca+ Norepinephrine Ca+ Phosphatidylinositol 4,5- bisphosphate L-Tyrosine Tetrahydrobiopterin O2 L-Dopa Dihydrobiopterin H2O Dopamine CO2 Ascorbic acid O2 Dehydroascorbic acid H2O Magnesium Calcium Manganese Ca+ Diacylglycerol Contraction Relaxation Gq signaling cascade Calcium Fe2+ Pyridoxal 5'-phosphate Pyrroloquinoline quinone Copper Prazosin inhibits alpha1 adrenergic receptor on the smooth muscle of the blood vessel Myosin LC-P interacts with actin to produce smooth muscle contraction. Since there are low levels of myosin LC-P, contraction is inhibited The Gq signaling cascade is activated, leading to the production of IP3 IP3 activates IP3 receptor on the sarcoplasmic reticulum leading to influx of calcium into the cytosol Calcium binds to calmodulin and activates myosin light chain kinase Cytosol Sarcoplasmic Reticulum Presynaptic neuron Calcium stimulates the release of norepinephrine into the synapse Norepinephrine activates presynaptic autoreceptors α2 adrenergic receptors activates the Gi signaling cascade that inhibits calcium channels Norepinephrine is taken back up to the presynaptic neuron and recycled Norepinephrine is synthesized from tyrosine and stored in synaptic vesicles Smooth muscle cell
MYLK ITPR1 ADRA1A ADRA2A CACNA1A CACNB1 CACNA2D2 ACTB MYL3 MYL3 PLCB1 SLC18A2 SLC6A2 CALM1 PPP1CB TH DDC DBH CALM1 Inositol 1,4,5- trisphosphate Norepinephrine Calcium Norepinephrine Calcium Calcium Norepinephrine Calcium Phosphatidylinositol 4,5- bisphosphate L-Tyrosine Tetrahydrobiopterin Oxygen L-Dopa Dihydrobiopterin Water Dopamine Carbon dioxide Ascorbic acid Oxygen Dehydroascorbic acid Water Calcium Diacylglycerol Contraction Relaxation Gq signaling cascade
MYLK ITPR1 ADRA1A ADRA2A CACNA1A CACNB1 CACNA2D2 ACTB MYL3 MYL3 PLCB1 SLC18A2 SLC6A2 CALM1 PPP1CB TH DDC DBH CALM1 Inotp Norpp Ca+ Norpp Ca+ Ca+ Norpp Ca+ P45P Tyr BH4 O2 L-Dopa BH3 H2O LDP